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A kind of medical degradable zinc-based composite material and its preparation method and application

A composite material and zinc-based technology, applied in medical science, surgery, etc., can solve problems such as difficult cleaning, poor corrosion resistance, and inability to meet the needs of orthopedic implants, and achieve moderate degradation speed

Active Publication Date: 2021-07-13
湖南华翔医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degradation products of pure magnesium and magnesium-based alloys are non-toxic and degradable, but their corrosion resistance is very poor, and they will be degraded soon in the human body, unable to provide sufficient mechanical support time
Existing alloy degradable materials mix zinc and other metals together through smelting, but the existing magnesium alloys of this type corrode too fast and zinc alloys corrode too slowly, which cannot meet the needs of orthopedic implants.
In the prior art, there is also a combination of multi-layer degradable metal materials through electroplating technology. However, the surface of the core layer needs to be chemically treated during electroplating. Requirements for orthopedic implant materials

Method used

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  • A kind of medical degradable zinc-based composite material and its preparation method and application
  • A kind of medical degradable zinc-based composite material and its preparation method and application

Examples

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Effect test

Embodiment 1

[0029] A medical degradable zinc-based composite material, the zinc-based composite material is cylindrical, including an inner layer and an outer layer, the inner layer 1 is magnesium, and the outer layer 2 is a zinc alloy; the zinc alloy is made of metal Zn, The composition of metal Mg and element X is, in terms of weight percentage, metal Zn 99.87%, metal Mg 0.01%, element X 0.1%, and the rest are unavoidable impurities; the element X is Cu.

[0030] The preparation method of the medical degradable zinc-based composite material comprises the following steps:

[0031] (1) Melting: Melt Zn5Mg and Zn9X master alloys using the existing technology, and detect the composition content of the final master alloy; then, in a melting mold with a cylindrical inner cavity, fix a magnesium rod with a diameter of 1mm on the axis of the inner cavity Center, forms inner layer, and the diameter of described inner chamber is 27mm; Then, with the measured value of Zn5Mg, Zn9X standard, get Zn,...

Embodiment 2

[0037] A medical degradable zinc-based composite material, the zinc-based composite material is cylindrical, including an inner layer and an outer layer, the inner layer is magnesium, and the outer layer is a zinc alloy; the zinc alloy is composed of metal Zn, metal Mg Composed of element X, according to weight percentage, metal Zn 99.83%, metal Mg 0.05%, element X 0.1%, and the rest are unavoidable impurities; the element X is Li.

[0038] The preparation method of the medical degradable zinc-based composite material comprises the following steps:

[0039] (1) Melting: Melt Zn5Mg and Zn9X master alloys using the existing technology, and detect the composition content of the final master alloy; then, in a melting mold with a cylindrical inner cavity, fix a magnesium rod with a diameter of 1mm on the axis of the inner cavity Center, forms inner layer, and the diameter of described inner chamber is 27mm; Then, with the measured value of Zn5Mg, Zn9X standard, get Zn, Zn5Mg, Zn9X,...

Embodiment 3

[0045] A medical degradable zinc-based composite material, the zinc-based composite material is cylindrical, including an inner layer and an outer layer, the inner layer is magnesium, and the outer layer is a zinc alloy; the zinc alloy is composed of metal Zn, metal Mg Composed of element X, according to weight percentage, metal Zn 99.78%, metal Mg 0.1%, element X 0.1%, and the rest are unavoidable impurities; the element X is Mn.

[0046] The preparation method of the medical degradable zinc-based composite material comprises the following steps:

[0047] (1) Melting: Melt Zn5Mg and Zn9X master alloys using the existing technology, and detect the composition content of the final master alloy; then, in a melting mold with a cylindrical inner cavity, fix a magnesium rod with a diameter of 1mm on the axis of the inner cavity Center, forms inner layer, and the diameter of described inner chamber is 27mm; Then, with the measured value of Zn5Mg, Zn9X standard, get Zn, Zn5Mg, Zn9X, ...

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Abstract

The invention discloses a medical degradable zinc-based composite material. The zinc-based composite material is cylindrical and includes an inner layer and an outer layer. The inner layer is magnesium and the outer layer is zinc alloy; the zinc alloy is made of metal Zn , metal Mg, element X and unavoidable impurities, according to weight percentage, metal Zn 96-99.87%, metal Mg 0.01-1%, element X 0.1-3%, unavoidable impurities 0.005-0.02%, said The element X is any one of Cu, Fe, Mn, Ca, Sr or Li; at the same time, the invention also discloses the preparation method of the zinc-based composite material and its application in the preparation of orthopedic implant devices. The zinc-based composite material, which uses magnesium as the inner layer and zinc alloy as the outer layer, can be degraded in layers and can be used for orthopedic implant devices. The degradation rate is moderate in a simulated human body fluid environment at 37°C.

Description

technical field [0001] The invention belongs to the technical field of biodegradable metals, in particular to a medical degradable zinc-based composite material and its preparation method and application. Background technique [0002] Zinc ions are an essential nutrient element for the human body and participate in many metabolic activities of the human body. The American Clinical Innovation Institute recommends that the human body must consume 2.5 to 6.4 mg of zinc per day. Adults may have certain toxicity if they consume about 300 mg of zinc per day. reaction. A zinc-based biodegradable bone nail releases about 0.2-0.3 mg of zinc per day. Even if all these zinc ions are released into blood vessels, it is far below the necessary intake of the human body. That is to say, zinc-based biodegradable orthopedic implants The zinc ions released by the degradation of medical devices will not cause systemic toxicity. The study also found that the transport of zinc ions in human tis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C18/02C22C18/00C22C1/03C22F1/16A61L31/02A61L31/14
Inventor 宁靠屈功奇吕轲赵志义陈彪屈雁林
Owner 湖南华翔医疗科技有限公司