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Fluconazole tablets and preparation method thereof

A fluconazole tablet and prescription technology, which is applied in the field of fluconazole tablet and its preparation, can solve the problems of dispersible tablet compressibility, poor friability, high cost, fragile tablet, etc. Effects of energy consumption, reduction of operating procedures, and improvement of production efficiency

Pending Publication Date: 2019-05-28
上海桓华制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the fluconazole tablet of the present application is owing to being subjected to the restriction of conditions such as technology, technology, equipment in the tabletting process, makes the compressibility of dispersible tablet, friability relatively poor, and tablet also breaks easily in packing process, Moreover, the process is complicated and the energy consumption is high, resulting in high cost

Method used

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  • Fluconazole tablets and preparation method thereof
  • Fluconazole tablets and preparation method thereof
  • Fluconazole tablets and preparation method thereof

Examples

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Effect test

preparation example Construction

[0016] A preparation method for fluconazole tablets, comprising the steps of:

[0017] 1) Put the above-mentioned materials into the blender according to the prescription quantity and mix them evenly;

[0018] 2) Determining the intermediate content and calculating the tablet weight;

[0019] 3) Use a tablet machine to directly compress tablets, aluminum-plasticize, and pack.

specific Embodiment 1

[0020] In terms of parts by weight, the following ingredients are weighed:

[0021]

[0022] Then put the above-mentioned materials into the blender according to the prescription amount and mix them evenly; measure the content of intermediates, and calculate the weight of the tablets; use the tablet machine to directly compress the tablets, aluminum-plasticize them, and pack them.

specific Embodiment 2

[0023] In terms of parts by weight, the following ingredients are weighed:

[0024]

[0025] Then put the above-mentioned materials into the blender according to the prescription amount and mix them evenly; measure the content of intermediates, and calculate the weight of the tablets; use the tablet machine to directly compress the tablets, aluminum-plasticize them, and pack them.

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PUM

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Abstract

The invention relates to fluconazole tablets. The fluconazole tablets comprise 40-50 parts of fluconazole, 30-40 parts of microcrystalline cellulose, 5 parts of anhydrous dicalcium phosphate, 10-15 parts of polyvidone K30, 8-10 parts of sodium cross-linked hydroxymethyl cellulosate and 1-3 parts of magnesium stearate. The invention further relates to a preparation method of the fluconazole tablets. The method comprises the steps: firstly, putting the materials in a total mixer according to prescription amounts, and carrying out uniform mixing; measuring the content of an intermediate, and calculating tablet weight; carrying out tabletting by a tabletting machine directly, and carrying out aluminum plastic packaging. According to the preparation method, operating procedures are reduced, theproduction efficiency is increased, the materials are saved, the energy consumption is lowered, and environmental pollution is reduced.

Description

technical field [0001] The invention belongs to the field of new technology for medicine manufacture, and in particular relates to a fluconazole tablet and a preparation method thereof. Background technique [0002] Fluconazole is a new type of triazole antifungal drug, developed by Pfizer, first listed in Denmark, France, Ireland and the United Kingdom in 1988, and approved by FDA in 1990 in the United States. This product is a drug for treating fungal infections. It is a broad-spectrum antifungal drug and has therapeutic effects on fungal infections in humans and animals. Currently, there are several dosage forms of tablets, capsules, powder injections and injections on the market. The mechanism of action of this product is mainly to highly selectively interfere with the activity of fungal cytochrome P-450, thereby inhibiting the biosynthesis of ergosterol on the fungal cell membrane. This product is well absorbed when taken orally, and is not affected by food, antacids, ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4196A61P31/10
Inventor 肖娟韩峰谢云丽
Owner 上海桓华制药有限公司
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