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Medical composition for treating Parkinson 's disease and preparation method of medical composition

A Parkinson's disease and composition technology, applied in the field of pharmaceutical composition for the treatment of Parkinson's disease and its preparation, can solve problems such as difficulty in movement, short duration, impact on the quality of life and therapeutic effect of PD patients, and reduce side effects , Relieve symptoms, Definite effect of treatment

Inactive Publication Date: 2019-06-07
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After taking the medicine, the duration of symptom improvement becomes shorter and shorter, and the phenomenon of hyperactivity with difficulty in movement appears additionally, so that the patient often swings back and forth between severe lack of movement and uncontrollable hyperactivity. This symptom is called dyskinesia symptoms, seriously affecting the quality of life and treatment effect of PD patients

Method used

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  • Medical composition for treating Parkinson 's disease and preparation method of medical composition
  • Medical composition for treating Parkinson 's disease and preparation method of medical composition
  • Medical composition for treating Parkinson 's disease and preparation method of medical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: The preparation method of the pharmaceutical composition for the treatment of Parkinson's disease:

[0039] Take 10kg of aspirin, 25kg of levodopa, and 40kg of starch, mix evenly, then add 9kg of starch slurry with a water content of 5% to make a soft material, the soft material is granulated through a 16-mesh sieve, and the obtained granules are dried at 40 ° C. Sieve and granulate, weighing 59.2kg, then add 1.8kg of talcum powder, mix evenly, and tablet to obtain.

[0040] Dosage: 2-3 tablets each time, once a day.

Embodiment 2

[0041] Embodiment 2: The preparation method of the pharmaceutical composition for the treatment of Parkinson's disease:

[0042] Get aspirin 15kg, levodopa 40kg, and starch 280kg, mix uniformly, then add 87.5kg water content 15% starch slurry and make soft material, soft material passes 16 mesh sieve granulation, makes granule and is dried at 60 ℃, with 16 Mesh sieve granules, weighing 355.9kg, then add 28.4kg of talcum powder, mix evenly, and tablet.

[0043] Dosage: 2-3 tablets each time, once a day.

Embodiment 3

[0044] Embodiment 3: The preparation method of the pharmaceutical composition for the treatment of Parkinson's disease:

[0045] Take 10kg of aspirin, 25kg of levodopa, and 135kg of starch, mix evenly, then add 36kg of starch slurry with a water content of 10% to make a soft material, the soft material is granulated through a 16-mesh sieve, and the obtained granules are dried at 50 ° C. Sieve and granulate, weighing 180.0kg, then add 10kg of talcum powder, mix evenly, and tablet to obtain.

[0046] The aforementioned 36kg of 10% starch slurry contains 3.6kg of citric acid, which impels the tablet to increase the solubility of the drug after taking it, which is beneficial to the absorption of the drug.

[0047] Dosage: 2-3 tablets each time, once a day.

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Abstract

The scheme of the invention discloses a medical composition for treating Parkinson 's disease in the field of treatment medicines for the Parkinson 's disease. The medical composition consists of thefollowing active components in parts by weight of 5-20 parts of aspirin and 10-40 parts of levodopa. According to the medical composition disclosed by the invention, the aspirin and the levodopa are united to prevent and treat the Parkinson 's disease, the levodopa can alleviate symptoms of shaking palsy and improve muscular tension, besides, the synergistic reaction of medicines is exerted, dopaminergic neuron can be protected, the treatment scheme has precise treatment effects on the Parkinson 's disease, and besides, side effects caused by medicines in the treatment course of the Parkinson's disease can be notably reduced.

Description

technical field [0001] The invention relates to the field of drugs for treating Parkinson's disease, in particular to a pharmaceutical composition for treating Parkinson's disease and a preparation method thereof. Background technique [0002] Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss, degeneration and death of dopaminergic neurons in the substantia nigra compacta and striatum of the midbrain. Its typical clinical manifestations are resting tremor, muscle rigidity, bradykinesia, and posture instability. PD is second only to Alzheimer's disease in causing neurodegeneration in middle-aged and elderly people, and it brings a heavy burden to society and families. At present, the pathogenesis of PD is not clear, and the current treatment status is limited due to poor efficacy or side effects. Therefore, it is of great clinical significance to find effective treatment options to relieve the pain of PD patients. [0003] Levodopa (L...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61K31/198A61P25/16
Inventor 张锋李戴弟朱国富王国庆周延贞李晶洁
Owner ZUNYI MEDICAL UNIVERSITY
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