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A kind of preparation method of gamma-aminobutyric acid

A technology of aminobutyric acid and C-80, which is applied in the field of preparation of γ-aminobutyric acid, can solve problems such as crystal yellowing and crystal sticking to the wall

Active Publication Date: 2022-03-11
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the above problems, the present invention provides a preparation method of γ-aminobutyric acid, which solves the problems of crystal wall sticking and crystal yellowing in the process of crystal drying by optimizing and improving the process of concentration and cooling crystallization , Agglomeration problem, improved production efficiency and product quality, more conducive to industrial applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Decolorization: heat up the γ-aminobutyric acid conversion solution to 80-85°C, keep it warm for 1.5 hours to denature the protein, then cool down to 60-65°C, add activated carbon with 0.8% of the conversion solution mass, and filter after adsorption for 1.5 hours to obtain The filtrate is the γ-aminobutyric acid conversion solution after activated carbon decolorization.

[0024] 2. Concentration: Evaporate and concentrate the γ-aminobutyric acid conversion liquid after activated carbon decolorization, control the concentration temperature at 75-80°C, and vacuum degree at 0.06Mpa-0.1Mpa, stop the concentration when the concentrated liquid no longer flows, at this time, More crystals were precipitated in the concentrated solution.

[0025] 3. Cooling and crystallization: After transferring the above-mentioned concentrated solution to the cooling tank, turn on the stirring paddle, and the stirring speed is 55-60rpm. After turning on the stirring, let the temperature dr...

Embodiment 2

[0029] 1, decolouring: with embodiment 1.

[0030] 2. Concentration: Evaporate and concentrate the γ-aminobutyric acid conversion solution after activated carbon decolorization, control the concentration temperature at 55-60°C, and the vacuum degree at 0.06Mpa-0.1Mpa, and stop the concentration when the concentrated solution no longer flows. At this time, More crystals were precipitated in the concentrated solution.

[0031] 3. Cooling and crystallization: After transferring the above-mentioned concentrated solution to the cooling tank, turn on the stirring paddle with a stirring speed of 55-60rpm. After turning on the stirring, let the temperature drop naturally for 1 hour. After cooling down, intermittently pass cooling water at 10°C to the cooling tank, and control the cooling rate. After cooling down for 3 hours, the temperature inside the cooling tank is 15°C, and the temperature is maintained for crystallization.

[0032] 4, washing: with embodiment 1.

[0033]5. Dryin...

Embodiment 3

[0035] 1, decolouring: with embodiment 1.

[0036] 2. Concentration: Evaporate and concentrate the γ-aminobutyric acid conversion liquid after activated carbon decolorization, control the concentration temperature at 70-75°C, and vacuum degree at 0.06Mpa-0.1Mpa, stop the concentration when the concentrated liquid no longer flows, at this time, More crystals were precipitated in the concentrated solution.

[0037] 3. Cooling and crystallization: After transferring the above-mentioned concentrated solution to the cooling tank, turn on the stirring paddle, and the stirring speed is 55-60rpm. After turning on the stirring, let the temperature drop naturally for 2 hours. After cooling down, intermittently pass cooling water at 10°C to the cooling tank, and control the cooling rate. After cooling for 2 hours, the temperature inside the cooling tank is 30°C, and crystallization is carried out at this temperature.

[0038] 4, washing: with embodiment 1.

[0039] 5. Drying: Put the w...

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Abstract

The invention discloses a preparation method of γ-aminobutyric acid. The converted liquid of γ-aminobutyric acid after activated carbon decolorization is vacuum-concentrated, the concentrated solution is transferred to a cooling tank, the stirring is started, the temperature is naturally lowered first, and then cooled in the outside. Under the action of the source, the temperature is lowered, so that the temperature of the final concentrated solution is reduced to 15-30 ° C, and then the temperature is maintained for crystallization; the crystals are separated, washed, and dried to obtain γ-aminobutyric acid. The invention solves the problems of crystal wall sticking, agglomeration, yellowing, and drying difficulties during the drying process of large-scale production of γ-aminobutyric acid by optimizing and improving the methods of concentrated crystallization and cooling crystallization, and improves production efficiency and product quality. Quality, the obtained γ-aminobutyric acid has high purity and white appearance, which meets the requirements. After drying, it can be packaged and sold directly without further crushing treatment, which is more conducive to industrial applications.

Description

technical field [0001] The invention relates to a method for preparing gamma-aminobutyric acid from gamma-aminobutyric acid conversion liquid, in particular to a gamma-aminobutyric acid with simple operation, short drying time, non-sticky crystals, no agglomeration, and high purity during drying. The preparation method of aminobutyric acid. Background technique [0002] Gamma-aminobutyric acid (GABA), as an important inhibitory transmitter in brain tissue, has the functions of calming the nerves, lowering blood pressure, treating epilepsy and anti-aging. In addition, GABA tastes sweet, can adjust the taste of food, and can react with alcohol in the body, so it has the functions of sobering up and deodorizing. In medicine, GABA can be used to treat some diseases. For example, the medicines for treating uremia and CO poisoning all contain GABA. [0003] The synthesis methods of GABA mainly include chemical synthesis and biosynthesis. In the process of chemical synthesis of G...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/08C07C227/40C07C227/42
Inventor 董海光杨健民冯川王珂王泽秋王文劲穆惠军栾贻宏
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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