A preparation method and application of glutathione-responsive vanadium oxide nanoparticles

A vanadium oxide and nanoparticle technology is applied in the field of preparation of glutathione-responsive vanadium oxide nanoparticles, which can solve problems such as limited application, and achieve the effects of good biocompatibility, broad application prospects and simple operation.

Active Publication Date: 2021-06-15
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, high-valent vanadium oxides are highly toxic, which limits their application in vivo

Method used

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  • A preparation method and application of glutathione-responsive vanadium oxide nanoparticles

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of glutathione-responsive vanadium oxide nanoparticles comprises the following steps:

[0025] 1) Dissolve 0.5 g of ammonium metavanadate in 20 mL of distilled water, 0.5 g of hyaluronic acid in 50 mL of distilled water, stir well, and set aside;

[0026] 2) Heat ammonium metavanadate to 80°C and react for 20 minutes to obtain a golden yellow solution, that is, vanadium oxide solution A;

[0027] 3) Add the vanadium oxide solution A dropwise into the hyaluronic acid solution, stir evenly, transfer it to a high-temperature and high-pressure reactor, and stop heating after reacting at 90°C for 6 hours to obtain the hyaluronic acid-modified vanadium oxide solution B ;

[0028] 4) Add an equal volume of ethanol to the aqueous solution B obtained in the previous step, and centrifuge to obtain a yellow solid C;

[0029] 5) Wash solid C three times with ethanol, then centrifuge to obtain solid D;

[0030] 6) Dry the solid D in vacuum to obtain glutathione-re...

Embodiment 2

[0032] The preparation of glutathione-responsive vanadium oxide nanoparticles comprises the following steps:

[0033] 1) Dissolve 0.5 g of ammonium metavanadate in 20 mL of distilled water, 0.5 g of hyaluronic acid in 50 mL of distilled water, stir well, and set aside;

[0034] 2) Heat ammonium metavanadate to 80°C and react for 20 minutes to obtain a golden yellow solution, that is, vanadium oxide solution A;

[0035] 3) Add the vanadium oxide solution A dropwise into the hyaluronic acid solution, stir evenly, then transfer it to a high-temperature and high-pressure reactor, react at 90°C for 6 hours, and stop heating to obtain hyaluronic acid-modified vanadium oxide Solution B;

[0036] 4) Add an equal volume of ethanol to the aqueous solution B obtained in the previous step, and centrifuge to obtain a yellow solid C;

[0037] 5) Wash solid C three times with ethanol, then centrifuge to obtain solid D;

[0038] 6) Dry the solid D in vacuum to obtain glutathione-responsive...

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Abstract

The invention discloses a preparation method and application of glutathione-responsive vanadium oxide nanoparticles. The nanoparticles are synthesized by one-step method through ammonium metavanadate and hyaluronic acid. The preparation method of the invention is simple, and the raw materials are cheap and easy to obtain. The vanadium oxide nanoparticles modified by hyaluronic acid have the characteristics of good biocompatibility, good dispersibility in aqueous solution and the like. Moreover, after being incubated with glutathione, it has good absorption in the near-infrared region, can convert near-infrared light into heat energy, and can be used for photothermal therapy. The vanadium oxide nanoparticles prepared by the invention can be used for glutathione-responsive photothermal therapy in the tumor microenvironment, and have broad application prospects in the field of cancer photothermal therapy.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a preparation method and application of glutathione-responsive vanadium oxide nanoparticles. Background technique [0002] In recent years, diagnosis and treatment triggered by the inherent physiological microenvironmental characteristics of tumor tissues (such as redox state, pH, enzymes, ions, etc.) have attracted extensive attention. This treatment method can simultaneously reduce the damage of anticancer drugs to normal tissues and improve their therapeutic effect. Among various physiological parameters, redox status plays an important role in various pathological states such as chronic inflammation, stroke, cancer (Rubartelli, A.; Lotze, M. T. Trends Immunol . 2007.). Studies have shown that glutathione (GSH) is the most abundant reducing agent in tumors, and the content of glutathione in tumor tissues is significantly higher than that in normal tissues. The effect of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/14A61K47/61A61P35/00
Inventor 蒋邦平陈婷沈星灿卢钰周波孙婉莹
Owner GUANGXI NORMAL UNIV
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