Abstract
The invention belongs to the technical field of separation and purification of artemisinin, and concretely relates to an artemisinin separation and purification technology. The separation and purification technology comprises the following steps: S1, Sweet Wormwood Herb extract is concentrated, and undergoes press filtration to obtain first crude artemisinin crystals and a first mother liquor, thefirst mother liquor is concentrated under a reduced pressure to obtain a first artemisinin extract; S2, the first artemisinin extract is added to an alcohol-water solution, stirring is performed fordissolving and dispersing, and then separation is carried out to obtain a first alcohol-water extract and a second artemisinin extract; S3, the second artemisinin extract undergoes processes in step S2 to obtain a second alcohol-water extract and a third artemisinin extract; S4, the first alcohol-water extract and the second alcohol-water extract are mixed, and the obtained mixture is cooled and crystallized, and then undergo press filtration to obtain second crude artemisinin crystals and a second mother liquor; and S5, the first crude artemisinin crystals and the second crude artemisinin crystals are mixed, and are dissolved in an alcohol solvent, the obtained solution is filtered, and the obtained filtrate is heated, and then undergoes reduced pressure concentration, cooling, press filtration and drying to obtain refined artemisinin. The product obtained by the separation and purification technology has the advantages of high recovery rate, high purity and high crystal form quality.
Description
technical field
[0001] The invention belongs to the technical field of separation and purification of artemisinin, and in particular relates to a separation and purification process of artemisinin. Background technique
[0002] Artemisinin, also known as artemisinin, is a sesquiterpene lactone compound with a peroxy bridge extracted and isolated from the leaves of Artemisia annua of Compositae plant in 1971 by Chinese pharmaceutical workers. The preparation techniques of artemisinin mainly include plant extraction, biosynthesis, chemical synthesis and plant tissue culture. Directly extracting artemisinin from Artemisia annua can extract its active ingredients according to the solubility difference of various components in different solvents in Chinese herbal medicine. How to extract artemisinin more efficiently and ensure the purity of the product while reducing the energy loss in the extraction process is a technical problem to be solved in this field.
[0003] After sear...
