Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition for treating opioid-related constipation and processing method thereof

A kind of opioid drug and related technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of patients abandoning treatment, dehydration, abdominal distension and dermatitis, overuse, etc.

Inactive Publication Date: 2019-06-28
CHONGQING TRADITIONAL CHINESE MEDICINE HOSPITAL
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a risk of overuse of traditional laxatives, and many patients may develop tolerance to one or more laxatives, which may cause adverse reactions such as dehydration, abdominal distension, and dermatitis, which may eventually cause patients to give up treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for treating opioid-related constipation and processing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A pharmaceutical composition for treating opioid-related constipation, comprising 30g of astragalus, 30g of Cistanche, 60g of Atractylodes macrocephala, 15g of Magnolia officinalis, 15g of Citrus aurantium, 15g of betel nut, 30g of radish seed, 30g of hemp seed and 15g of Qingpi.

Embodiment 2

[0031] A pharmaceutical composition for treating opioid-related constipation, comprising 20g of astragalus, 30g of Cistanche, 45g of Atractylodes macrocephala, 20g of Magnolia officinalis, 20g of Citrus aurantium, 20g of betel nut, 25g of radish seed, 35g of hemp seed and 15g of Qingpi.

Embodiment 3

[0033] A pharmaceutical composition for treating opioid-related constipation, comprising 40g of astragalus, 25g of Cistanche, 60g of Atractylodes macrocephala, 12g of Magnolia officinalis, 25g of Citrus aurantium, 25g of betel nut, 35g of radish seed, 25g of hemp seed and 25g of Qingpi.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a pharmaceutical composition for treating opioid-related constipation and a processing method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The pharmaceutical composition is prepared from, by mass, 20-40 parts of radix astragali, 20-40 parts of desertliving cistanche, 40-70 parts of rhizoma atractylodis macrocephalae, 10-30 parts of cortex magnoliae officinalis, 10-30 parts of fructus aurantii immaturus, 10-30 parts of semen arecae, 20-40 parts of semen raphani, 20-40 parts of fructus cannabis and 10-30 parts of pericarpium citri reticulatae viride. Astragalus membranaceus is the monarch drug, rhizoma atractylodis macrocephalae, fructus cannabis, desertliving cistanche, cortex magnoliae officinalis and fructus aurantii immaturus are minister drugs; pericarpium citri reticulatae viride, semen arecae and semen raphani are assistant drugs. All the drugs are compatible, the synergistic effect is achieved, and the medicinalmaterials have the synergistic effects of benefiting qi, invigorating the spleen, promoting qi and dissipating swelling, moistening the intestines and facilitating feces excretion. The tests show thatthe pharmaceutical composition can treat opioid-related constipation more significantly.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a pharmaceutical composition for treating opioid-related constipation and a preparation method thereof. Background technique [0002] In recent years, with the advancement of science and technology and the development of economy, the incidence of cancer has been increasing. One of the main symptoms of cancer is cancer pain, and the incidence of cancer pain in patients with malignant tumors can reach 31% to 90%. Opioids are widely used in the analgesic treatment of cancer patients because of their analgesic effect without a ceiling effect. The WHO cancer pain three-step analgesic principle recommends: severe cancer pain should be treated with opioids. [0003] Opioid-induced gastrointestinal dysfunction (OIBD) is a common adverse reaction of this type of drug, among which opioid-induced constipation (OIC) is the most common, with an in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/889A61P1/10
Inventor 宋娜程俊赖宗浪孟令占艾亮邱敏王娟邹文娟
Owner CHONGQING TRADITIONAL CHINESE MEDICINE HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products