Unlock instant, AI-driven research and patent intelligence for your innovation.

Dental implant surface coating and preparation method thereof

A surface coating and dental implant technology, applied in the field of medical material manufacturing, can solve the problems of reduced effectiveness, instability, degeneration, etc., and achieve excellent biocompatibility and bone fusion, and ensure the effect of mechanical strength.

Active Publication Date: 2019-07-05
MAXHEALTH MEDICAL GRP CO LTD
View PDF4 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the substance coated on the surface of the implant itself is a substance that induces the differentiation of osteoblasts and has strong osteoinductive properties, when it is actually applied to the surface of the implant used in dentistry, since the substance coated The implant surface (of a certain substance) is not regulated, or the protein coating material is unstable, and there are problems such as reduced effectiveness and denaturation due to gamma sterilization during long-term storage.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A method for preparing a dental implant surface coating, comprising the following steps:

[0046] (1) Digest the freeze-dried decellularized soft tissue with 0.1 M hydrochloric acid solution containing 1 mg pepsin for 24 hours to obtain a solution containing the decellularized matrix, and adjust the pH of the solution to 7 until it becomes a hydrogel;

[0047](2) Add hydroxyapatite particles in the range of 10-500 microns to the hydrogel obtained in step (1) to obtain a composite mixture, wherein the composite mixture comprises 5%wt% of acellular matrix and 95wt% of Hydroxyapatite;

[0048] (3) Apply the composite mixture obtained in step (2) to the surface of the roughened implant, and finally dry and sterilize.

Embodiment 2

[0050] A method for preparing a dental implant surface coating, comprising the following steps:

[0051] (1) Digest the freeze-dried decellularized soft tissue with 0.5M hydrochloric acid solution containing 5 mg of pepsin for 48 hours to obtain a solution containing the decellularized matrix, and adjust the pH of the solution to 9 until it becomes a hydrogel;

[0052] (2) Add hydroxyapatite particles in the range of 10-500 microns to the hydrogel obtained in step (1) to obtain a composite mixture, wherein the composite mixture comprises 20wt% acellular matrix and 80wt% hydroxyphosphorus gray stone;

[0053] (3) Apply the composite mixture obtained in step (2) to the surface of the roughened implant, and finally dry and sterilize.

Embodiment 3

[0055] A method for preparing a dental implant surface coating, comprising the following steps:

[0056] (1) Spray coating on the implant surface after roughening treatment contains 40wt% TiO 2 and a bottom layer of 60 wt% hydroxyapatite;

[0057] (2) Digest the freeze-dried decellularized soft tissue with 0.3M hydrochloric acid solution containing 3 mg of pepsin for 36 hours to obtain a solution containing the decellularized matrix, and adjust the pH of the solution to 7 until it becomes a hydrogel;

[0058] (3) Add hydroxyapatite particles in the range of 10-500 microns to the hydrogel obtained in step (2) to obtain a composite mixture, wherein the composite mixture comprises 15wt% acellular matrix and 85wt% hydroxyphosphorus gray stone;

[0059] (4) Apply the composite mixture obtained in step (3) to the surface of the bottom layer obtained in step (1), and finally dry and sterilize.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides dental implant surface coating and a preparation method thereof. The surface coating comprises 5-20wt% of acellular matrix and 60-95wt% of hydroxyapatite. The surface coating isprepared by compounding the acellular matrix and the hydroxyapatite according an appropriate proportion. The dental implant surface coating has the advantages that the surface coating is excellent inbiocompatibility and bone fusion performance, a TiO2-hydroxyapatite base layer can be added into the coating to increase the adhesive force and stability of the coating, or PLGA can be added to the outer layer of the coating to further guarantee mechanical strength.

Description

technical field [0001] The invention relates to the technical field of medical material manufacturing, in particular to a dental implant surface coating and a preparation method thereof. Background technique [0002] The currently widely used surface treatment methods for dental implants can be said to be the mechanical processing method RBM (Resorbable Blasted Media blasting) and the chemical processing method SLA (Sandblast Large Particle Acid Etching, Sandblast Large) which uses acidic substances to treat the surface. grit acid etc. The surface of the implant treated by these methods has a wider surface area and higher roughness than the surface treated by the existing general processing methods, which is conducive to the differentiation of osteoblasts and has the ability to make the bone and the implant more stable. The advantage of increased bone fusion performance between. [0003] However, when the surface-treated implants for dentistry are exposed to the air, an ox...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/30A61L27/28A61L27/34A61L27/06A61L27/50
CPCA61L27/06A61L27/28A61L27/306A61L27/32A61L27/34A61L27/50A61L2400/18A61L2420/02A61L2420/04A61L2420/06A61L2420/08A61L2430/12A61L2430/40C08L67/04
Inventor 缪丰东周洪吴锡
Owner MAXHEALTH MEDICAL GRP CO LTD