A kind of preparation method and application of the schiff base complex of binuclear copper
A technology of complexes and base ligands, which is applied in the field of preparation of Schiff base complexes, can solve the problems of cumbersome preparation process and low yield of complexes, achieve simple preparation methods and post-treatment methods, good crystal form stability, The obvious effect of anti-tumor activity
Active Publication Date: 2021-05-25
SHAANXI SCI TECH UNIV
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Problems solved by technology
[0003] The preparation process of traditional complexes is cumbersome, and the solvent evaporation method is generally used, which usually takes 4-7 days or even longer, and the yield is low
Method used
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Effect test
Embodiment 1
[0024] Mix methanol and acetonitrile at a volume ratio of 2:1 to obtain mixed solvent 1;
[0025] Mixed solvent 2 was obtained by mixing acetonitrile and dichloromethane at a volume ratio of 3:1.
[0026] The mixed solvent 3 was obtained by mixing methanol and dichloromethane at a volume ratio of 1:1.
Embodiment 2
[0028] Schiff base ligand compound 1 was obtained by dissolving 0.1 mmol of 1-(4-methoxyphenyl)-1,3-butanedione and 0.1 mmol of 2-aminophenol in 6 mL of mixed solvent 1 for aldol condensation reaction.
Embodiment 3
[0030] Schiff base ligand compound 2 was obtained by dissolving 0.1 mmol of 1-(4-methoxyphenyl)-1,3-butanedione and 0.1 mmol of 2-aminophenol in 7 mL of mixed solvent 2 for aldol condensation reaction.
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The invention discloses a preparation method and application of a dinuclear copper Schiff base complex. The present invention obtains solution 1 by dissolving copper salt in a mixed solvent under constant stirring; then dissolving the Schiff base ligand compound in a mixed solvent to obtain solution 2, adding solution 1 to solution 2, and stirring constantly for 0.5- After 1.0 h, solution 3 was obtained after filtration; then solution 3 was placed in a high-pressure reactor, and after program-controlled heating and cooling, a Schiff base complex of dinuclear copper in light blue crystals was obtained. The Schiff base complex of dinuclear copper in the invention has good crystal form stability, and the preparation method and post-treatment method are relatively simple. In the anti-tumor activity test, it has obvious anti-tumor activity, which can provide an important realistic basis for future anti-tumor drug research.
Description
technical field [0001] The invention belongs to the technical field of anticancer drugs, and in particular relates to a preparation method and application of a dinuclear copper Schiff base complex. Background technique [0002] Schiff alkali metal complexes have been widely used in antibacterial and antitumor applications due to their unique functional groups, which has attracted more and more attention to such complexes. At present, metal complexes represented by cisplatin have been clinically used as the first choice for anti-tumor drugs. The application of anti-tumor complexes drives the development of coordination chemistry in the medical field. Metallic copper is an essential trace element for the human body and participates in the oxidation of cytochrome C. [0003] Traditional complexes are relatively cumbersome in the preparation process, and the slow evaporation of solvents is generally used, which usually takes 4-7 days or even longer, and the yield is low. To t...
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IPC IPC(8): C07F1/08A61P35/00
CPCA61P35/00C07B2200/13C07F1/005
Inventor 季晓晖
Owner SHAANXI SCI TECH UNIV