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Urinary Protein Markers of Chronic Obstructive Pulmonary Disease and Its Application in Early Diagnosis

A chronic obstructive, early diagnosis technology, applied in the field of clinical medicine

Active Publication Date: 2020-10-09
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, the early diagnosis and timely and precise treatment of COPD cannot be determined only by pulmonary function tests.

Method used

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  • Urinary Protein Markers of Chronic Obstructive Pulmonary Disease and Its Application in Early Diagnosis
  • Urinary Protein Markers of Chronic Obstructive Pulmonary Disease and Its Application in Early Diagnosis
  • Urinary Protein Markers of Chronic Obstructive Pulmonary Disease and Its Application in Early Diagnosis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1. Establishment of chronic obstructive pulmonary disease rat model

[0033] 1. Smoking-induced chronic obstructive pulmonary disease rat model is currently a commonly used animal model for studying the disease, and is suitable for studying pathophysiological and morphological changes during the progression of chronic obstructive pulmonary disease.

[0034] Using this animal model to simulate the pathogenesis of COPD and observe the overall changes of the disease from onset to early stage and continuous progress has important guiding significance for clinical early diagnosis of COPD and monitoring the progress of COPD.

[0035] 2. Materials and Reagents

[0036] 1) Instrument:

[0037] Rat metabolic cage: purchased from Beijing Jiayuan Xingye Technology Co., Ltd.;

[0038] Thermo-Orbitrap Lumos was purchased from Thermo Corporation.

[0039] 2) Main reagents:

[0040] Deionized water was from MillliQ RG ultrapure water system; chromatographic grade aceton...

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Abstract

The invention relates to a urine protein marker for chronic obstructive pulmonary disease and THE application of the urine protein marker to early diagnosis, in specific, relates to the use of a chronic obstructive pulmonary disease urine protein marker in the early diagnosis of human chronic obstructive pulmonary disease. The urine protein marker is a component and a combination of components selected from apolipoprotein A-IV, vitamin D binding protein, plasminogen, fetuin A, brain acid soluble protein-1, a trefoil factor-1, matrix remodeling associated protein-8, nucleoside diphosphate kinase-B, L-lactic dehydrogenase B chain, phosphoglycerate kinase-1, Na(+) / H(+) exchange regulatory factor-3, and galectin-3 binding protein. With the urine protein marker provided by the invention adopted, early diagnosis can be performed on the chronic obstructive pulmonary disease, the diagnosis level of the COPD can be improved, and timely treatment can be performed.

Description

technical field [0001] The invention relates to clinical medicine; it relates to urine protein markers related to human chronic obstructive pulmonary disease. Specifically, the present invention relates to a urine protein marker related to the diagnosis of human chronic obstructive pulmonary disease obtained by using a chronic obstructive pulmonary disease rat disease model and mass spectrometry proteomics technology, and its use. Background technique [0002] Disease markers are monitorable changes related to the disease process, which are of great significance for disease diagnosis, disease course monitoring, disease prognosis prediction and treatment effect evaluation. [0003] Compared with blood, urine is not regulated by a homeostasis mechanism. It is a metabolite of the body, enriches various changes in the body, and can be obtained in large quantities in a non-invasive manner. It is an ideal source of disease markers and is used in the early diagnosis of diseases. h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/6803
Inventor 高友鹤黄鹤
Owner BEIJING NORMAL UNIVERSITY
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