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Activator and inhibitor of profibrinolysin and agent of external use for skin for mating it

A technology of blood fibrin and lysozyme, applied in the direction of skin diseases, skin care preparations, enzymes, etc., can solve problems such as ignorance of technology, improvement, and insufficient prevention effect

Inactive Publication Date: 2005-04-27
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no such technology is known so far
[0005] However, no matter what kind of technology used in the past, its improvement and preventive effects may not be sufficient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0175] Embodiment 1 Cream (moisturizing cream cream)

[0176] (formula) wt%

[0177] 1) Monoglyceryl stearate 2.0

[0178] 2) Stearyl Alcohol 4.0

[0179] 3) Beeswax 3.0

[0180] 4) Lanolin 5.0

[0181] 5) Ethylparaben 0.3

[0182] 6) P.O.E (20mol)

[0183] Sorbitan Monooleate 2.0

[0184] 7) Squalane 20.0

[0185] 8) Zinc oxide (silica coated FINEX-25) 5.0

[0186] 9) Spice 0.2

[0187] 10) 1,3-butanediol 5.0

[0188] 11) Glycerin 5.0

[0189] 12) Distilled water balance

[0190] (preparation method)

[0191] Heat 1) to 7) and 9) and keep at 75°C (oil phase). After dissolving 10) and 11) in 12), add 8) to disperse and heat to 75°C (water phase). The water phase was added to the oil phase, it was uniformly emulsified using a homomixer, and it cooled to 30 degreeC, fully stirring.

Embodiment 2

[0192] Example 2 powdered external preparation

[0193] (formula) wt%

[0194]1) Talc powder 49.95

[0195] 2) Zinc oxide (silica coated FINEX-50) 50.0

[0196] 3) Spice 0.05

[0197] (preparation method)

[0198] 3) was sprayed uniformly, stirring and mixing 1) and 2) thoroughly using a blender.

Embodiment 3

[0199] Example 3 Baby powder

[0200] (formula) wt%

[0201] 1) Talc powder 77.0

[0202] 2) Calcium carbonate 17.0

[0203] 3) Starch 0.5

[0204] 4) Zinc oxide (silica coated FINEX-75) 5.0

[0205] 5) Fungicide 0.3

[0206] 6) Preservatives 0.2

[0207] (preparation method)

[0208] 1) to 6) were fully stirred and mixed using a blender.

[0209] Embodiment 4 Lipstick

[0210] (formula) wt%

[0211] 1) Hydrocarbon wax 3.0

[0212] 2) Candelilla Wax 1.0

[0213] 3) Glyceryl isostearate 4

[0214] 4) Liquid paraffin 0.0

[0215] 5) Red No. 202 46.448

[0216] 6) Red No. 204 0.5

[0217] 7) Red No. 223 2.0

[0218] 8) Zinc oxide (silicon dioxide is 0.05

[0219] over ACTIVOX) 3.0

[0220] 9) Titanium dioxide 4.0

[0221] 10) Spice 0.002

[0222] (preparation method)

[0223] After heating 1) to 4) to 85° C. to dissolve, 5) to 9) were added thereto, stirred and mixed, and then 10) was stirred and mixed, filled in a container, and cooled.

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Abstract

The present invention relates to a plasminogen activator inhibitor, an external preparation for skin comprising the same, a method for improving rough skin and in particular, to improvement of an effective inorganic component. A plasminogen activator inhibitor contains a specific zinc oxide which adsorbs a plasminogen activator and effectively inhibits its activity. When it is used as an external preparation for skin, excellent improvement of rough skin is obtainable. Further when silica-coated zinc oxide is applied as an external preparation for skin, excellent improvement effect and prevention effect for rough skin are obtainable without an intolerance sensitivity reaction in the case of morbid dermatitis such as atopic dermatitis.

Description

technical field [0001] The present invention relates to a plasminogen activator inhibitor, an external preparation for skin containing the inhibitor, and a method for improving rough skin by using the external preparation for skin, especially an improvement of an inorganic active ingredient. Background technique [0002] Hitherto, various therapeutic drugs, skin external preparations, cosmetics and the like are known as having improvement and preventive effects on skin diseases, rough skin, acne and the like. As active ingredients in these existing pharmaceuticals or cosmetics, anti-inflammatory agents or animal and plant extracts believed to have anti-inflammatory effects, or amino acids or polysaccharides, lipids, and natural polymers with high moisturizing and water-retaining effects, prevent Inflammation of the skin (affected part) or moisture loss of the stratum corneum are excellent, and thus are widely used. [0003] On the other hand, in the case of dermatitis such ...

Claims

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Application Information

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IPC IPC(8): A61K8/27A61K33/30A61P17/00A61P17/12A61Q1/02A61Q1/06A61Q1/10A61Q1/12A61Q19/00C12N9/70
CPCA61Q1/02A61K8/27A61Q1/06A61Q19/00A61Q1/10Y10S514/861A61K2800/70A61K33/30A61Q1/12Y10S514/859A61P17/00A61P17/12
Inventor 吉田雄三河合江理子
Owner SHISEIDO CO LTD
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