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A composition for repairing damage, its preparation method and application

A technology for repairing damage and a composition, which is applied in the field of a pharmaceutical composition for promoting meniscus damage repair and its preparation field, can solve problems such as a composition without cartilage tissue damage, and achieves simple preparation method, low preparation cost, and improved repair degree of effect

Inactive Publication Date: 2020-01-21
NANJING FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As far as the current research is concerned, there is still no relatively simple and reliable composition for repairing cartilage tissue damage

Method used

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  • A composition for repairing damage, its preparation method and application
  • A composition for repairing damage, its preparation method and application
  • A composition for repairing damage, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: A kind of pharmaceutical composition and preparation method thereof for repairing damage

[0034] A pharmaceutical composition for repairing damage, comprising bone marrow mesenchymal stem cells and KGN-PRP gel.

[0035] A preparation method for a pharmaceutical composition for repairing damage, comprising the following preparation steps:

[0036] S1. Take 10 platelet-rich plasma gel and add 5 captoginine small molecules, stir and mix evenly to obtain a mixture;

[0037] S2. Add 5 × 10 to S1 5 bone marrow mesenchymal stem cells and mixed evenly;

[0038] S3. Add thrombin to S2 and mix well.

Embodiment 2

[0039] Embodiment 2: A kind of pharmaceutical composition and preparation method thereof for repairing damage

[0040] A pharmaceutical composition for repairing damage, comprising bone marrow mesenchymal stem cells, KGN-PRP gel, thrombin and B vitamin solution.

[0041] Among them, the b vitamin solution contains vitamin B per milliliter 1 0.3 mg, B vitamins 2 0.06 mg, B vitamins 6 0.09 mg; the activity of thrombin is 10000U / ml.

[0042] A preparation method for a pharmaceutical composition for repairing damage, comprising the steps of:

[0043] S1. Take 10 platelet-rich plasma gel and add 5 captoginine small molecules, stir and mix evenly to obtain a mixture, and add 0.5b vitamin solution to it;

[0044] S2. Add 5 × 10 to S1 5 bone marrow mesenchymal stem cells and mixed evenly;

[0045] S3. Add 5 thrombin to S2 and mix well.

Embodiment 3

[0046] Embodiment 3. A kind of pharmaceutical composition and preparation method thereof for repairing damage

[0047] A pharmaceutical composition for repairing damage, comprising bone marrow mesenchymal stem cells, KGN-PRP gel, thrombin, B vitamin solution and statin. Among them, the B vitamin solution contains 0.3 mg of vitamin B1, 0.06 mg of vitamin B2, and 0.09 mg of vitamin B6 per milliliter; the activity of thrombin is 10000 U / ml, and the statin is simvastatin.

[0048] A preparation method for a pharmaceutical composition for repairing damage, comprising the steps of:

[0049] S1. Take 10 platelet-rich plasma gel and add 5 captoginine small molecules, stir and mix evenly to obtain a mixture, and add 0.5b vitamin solution to it;

[0050] S2. Add 5 × 10 to S1 5 bone marrow mesenchymal stem cells and mixed evenly;

[0051] S3. Add 0.5 mg of simvastatin and 5 thrombin to S2 and mix well.

[0052] The pharmaceutical composition of the present invention is used to repair t...

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PUM

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Abstract

The invention discloses a composition for repairing an injury and a preparation method thereof, belongs to the field of cartilage tissue injury repair, and aims at providing a composition for promoting injury repairing and healing. According to the technical scheme, the composition is characterized by comprising bone marrow mesenchymal stem cells, KGN-PRP gel and thrombin, and the preparation method of the composition comprises the steps that S1, platelet-rich plasma gel is taken, kartogenin small molecules are added in the platelet-rich plasma gel, and stirring and mixing are conducted untilthe mixture is uniform to obtain the mixture; S2, the bone marrow mesenchymal stem cells are added in S1, and mixing is conducted until the mixture is uniform; S3, the thrombin is added in S2. Accordingly, the platelet-rich plasma gel is mixed with the bone marrow mesenchymal stem cells and combined with KGN for use, the synergistic effect between KGN and PRP is achieved, the injury repairing timeis effectively shortened, the repair degree of the injury is improved, and the pharmaceutical composition is simple in preparation method and low in preparation cost.

Description

technical field [0001] The invention relates to the technical field of cartilage tissue damage repair, in particular to a pharmaceutical composition for promoting repair of meniscus damage and a preparation method thereof. Background technique [0002] Articular cartilage defects caused by trauma and various diseases are very common in clinical practice. With the aging of the population in my country, the number of patients is increasing day by day, but the self-repair function of articular cartilage is very limited, so the repair and reconstruction of articular cartilage damage has always been a longing for people It is particularly important to solve the problem of articular cartilage repair and related research. Improving and enhancing the healing ability of cartilage tissue is a long-term challenge for both clinicians and basic research workers. As far as the current research is concerned, there is still no relatively simple and reliable composition for repairing cartila...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/48A61P19/04A61K35/28A61K31/196A61K35/16A61K31/51A61K31/525A61K31/4415A61K31/366A61K31/22
CPCA61K31/196A61K31/22A61K31/366A61K31/4415A61K31/51A61K31/525A61K35/16A61K35/28A61K38/4833A61P19/04C12Y304/21005A61K2300/00
Inventor 黄河徐鸿尧戴志宏邹相杰夏鹏程
Owner NANJING FIRST HOSPITAL