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A biomedical magnesium alloy with high corrosion resistance and uniform degradation and preparation method thereof

A biomedical and magnesium alloy technology, applied in the field of biomedical magnesium alloys, can solve problems such as unclear toxic and side effects, achieve broad clinical application prospects, easy industrial mass production, and improve biocompatibility.

Active Publication Date: 2021-02-05
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the existing commercial magnesium alloys contain aluminum (Al) and rare earth elements. Studies have shown that excessive Al can cause senile dementia, and the toxic and side effects of various rare earth elements on the human body are still unclear.

Method used

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  • A biomedical magnesium alloy with high corrosion resistance and uniform degradation and preparation method thereof
  • A biomedical magnesium alloy with high corrosion resistance and uniform degradation and preparation method thereof
  • A biomedical magnesium alloy with high corrosion resistance and uniform degradation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing a magnesium alloy, comprising the steps of:

[0035] (1) Weigh raw material pure Mg (99.99%), pure Zn (99.99%), pure Mn (99.99%) according to the ratio of Mg:Zn:Mn=98:1:1;

[0036] (2) Put pure magnesium and other materials together in a graphite crucible, heat the resistance furnace to 760°C to melt all raw materials, and keep stirring, stop heating and let stand;

[0037] (3) After smelting, pour the melt into a steel mold preheated to 200°C, and finally cool it completely to obtain a Mg-Zn-Mn-Sr quaternary alloy;

[0038] The entire smelting process is carried out in CO 2 (99.5%) and SF 6 (0.5%) in a mixed protective gas.

Embodiment 2

[0040] A method for preparing a magnesium alloy, comprising the steps of:

[0041] (1) Weigh raw material pure Mg (99.99%), pure Zn (99.99%), pure Mn (99.99%), pure Sr (99.99%) according to the ratio of Mg:Zn:Mn:Sr=97.5:1:1:0.5 , where Sr (99.99%) added 0.5%;

[0042] (2) Put pure magnesium and other materials together in a graphite crucible, heat the resistance furnace to 760°C to melt all raw materials, and keep stirring, stop heating and let stand;

[0043] (2) After smelting, pour the melt into a steel mold preheated to 200°C, and finally cool completely to obtain a Mg-Zn-Mn-Sr quaternary alloy;

[0044] The entire smelting process is carried out in CO 2 (99.5%) and SF 6 (0.5%) in a mixed protective gas.

Embodiment 3

[0046] The specific preparation method is the same as that of Example 2, but, wherein Mg:Zn:Mn:Sr=97:1:1:1.

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PUM

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Abstract

The invention provides a biomedical magnesium alloy with high corrosion resistance and uniform degradation, and the degradable magnesium alloy includes strontium (Sr). The magnesium alloy is Mg-Zn-Mn system. The added mass fraction of strontium (Sr) is 1.0-1.5%. The invention further improves the biocompatibility of the magnesium alloy by adding a small amount of Sr element to the Mg-Zn-Mn alloy on the basis of improving the mechanical properties, and changes the corrosion type of the alloy from localized corrosion to uniform corrosion. The alloy system of the present invention has a compact structure, and Sr exists in the form of Mg17Sr2 phase in the alloy; and the corrosion product is a Ca / P compound close to the composition of human bone, and has good biocompatibility.

Description

technical field [0001] The invention relates to a biomedical magnesium alloy that can be completely degraded in vivo, in particular to a degradable magnesium alloy that improves mechanical properties, corrosion behavior and biocompatibility by adding specific alloy elements in a small amount. Background technique [0002] Magnesium and magnesium alloys are extremely close to the dense bone of the human body because of their density. Moreover, the elastic modulus is closer to that of human bone than other inert metal materials, which can effectively avoid the stress shielding effect. In addition, magnesium is an essential element for the human body. Healthy adults need to take in 420mg per day. Excess magnesium can be excreted through urine and will not cause damage to the human body. Moreover, studies have shown that appropriate magnesium can promote the proliferation and differentiation of bone cells. [0003] However, due to the low corrosion potential of magnesium, it i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C23/00C22C23/04C22C1/02
CPCC22C1/02C22C23/00C22C23/04
Inventor 崔中雨潘辉葛峰杨超强王力伟王昕
Owner OCEAN UNIV OF CHINA
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