Quality detecting method and identification application for preparation of traditional Chinese medicine or traditional Chinese medicine composition

A quality inspection method and composition technology, which can be applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of difficulty in controlling the quality of traditional Chinese medicines and increasing the difficulty of complex analysis of traditional Chinese medicine components.

Active Publication Date: 2019-07-19
DOJINDO
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0002] Traditional Chinese medicine has the characteristics of multiple chemical components and multiple sources of medicine at the same time, which leads to the complexity of the quality control of traditional Chinese medicines; Chinese medicine compound preparations are composed of multi-flavored Chinese medicines, which not only increases the difficulty of complex analysis of Chinese medicine components, but also makes it difficult to It is more difficult to control the quality of each raw material Chinese medicine in the finished Chinese medicine compound preparation

Method used

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  • Quality detecting method and identification application for preparation of traditional Chinese medicine or traditional Chinese medicine composition
  • Quality detecting method and identification application for preparation of traditional Chinese medicine or traditional Chinese medicine composition
  • Quality detecting method and identification application for preparation of traditional Chinese medicine or traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] 1 Instruments and reagents

[0125] 1.1 Instrument

[0126] Waters Acquity HClass ultra-high performance liquid chromatography (including quaternary pump, 2996DAD detector, column thermostat, automatic sampler, Empower workstation); ultrasonic cleaner (KQ-250DE CNC ultrasonic cleaner, Kunshan Ultrasonic Instrument Co., Ltd. ); Mettler ML 204 electronic analytical balance (Swiss Mettler-Tolly Group); Mettler XP205 electronic analytical balance (Swiss Mettler-Tolly Group), 0.22 μm microporous membrane (Tianjin Jinteng Experimental Equipment Co., Ltd. company).

[0127] 1.2 Reagent

[0128] Acetonitrile (Merck, chromatographically pure), anhydrous formic acid (analytical pure, Tianjin Guangfu Institute of Fine Chemicals), ultrapure water (milli-Q ultrapure water instrument). Reference substances: berberine hydrochloride (content 86.8%, batch number 110713-201613;), palmatine hydrochloride (content 86.8%, batch number 110732-201611), berberine hydrochloride (content 95.1...

Embodiment 2

[0163] Embodiment 2, different sample detection

[0164] Eleven medicinal materials of Angongniuhuang Pills prescription and honey as an excipient were taken respectively. According to the proportion of the prescription, the established sample processing method and characteristic map analysis method were used for sample injection and determination, and the chemical components of 14 characteristic peaks in the ANW characteristic map were identified. And analyze the sources of 35 characteristic peaks. These include 10 characteristic peaks of Coptidis Rhizoma, 9 characteristic peaks of Scutellaria baicalensis, 9 characteristic peaks of Gardenia, 4 characteristic peaks of Curcuma, 2 characteristic peaks of Bezoar, and 1 characteristic peak of natural musk. The results are shown in Table 9, Figure 25 ~ Figure 28 .

[0165] Table 9 Information of 35 characteristic peaks in the characteristic spectrum of Angongniuhuang Pills

[0166]

[0167]

[0168] The method of the pres...

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Abstract

The invention provides a quality detecting method and identification application for preparation of a traditional Chinese medicine or a traditional Chinese medicine composition. The detecting method comprises the following steps of preparing a test solution after extracting the preparation of the traditional Chinese medicine or the traditional Chinese medicine composition to be tested by a solvent; and subjecting the test solution to high performance liquid chromatography to analyze the quality of the preparation of the traditional Chinese medicine or the traditional Chinese medicine composition, wherein the acetonitrile (A)-acid aqueous solution (B) is used as a mobile phase, the gradient elute is adopted, and the detecting wavelength is 190-500nm. The method provided by the invention hasclearly defined characteristic peak with no negative interference due to the verification by the negative-lacking experiment of each single-flavored medicine, can be used for the quality detection ofthe preparation of the traditional Chinese medicine or the traditional Chinese medicine composition containing natural bezoar, bezoar, natural musk, musk, astragalus, berberine, medlar and turmeric,and can be used for the authenticity identification of the preparation of natural musk, natural bezoar and its traditional Chinese medicine composition by the test of characteristic peaks.

Description

technical field [0001] The invention relates to a quality detection method and identification application of a traditional Chinese medicine or a Chinese medicine composition preparation, specifically, a method for detecting a Chinese medicine composition preparation by high-performance liquid chromatography, and its application to a method containing natural bezoar and bezoar , natural musk, musk, baicalin, berberine, gardenia, turmeric and other applications such as quality testing (including identification) of traditional Chinese medicine or Chinese medicine composition preparations, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Traditional Chinese medicine has the characteristics of multiple chemical components and multiple sources of medicine at the same time, which leads to the complexity of quality control of traditional Chinese medicines; Chinese medicine compound preparations are composed of multi-flavored Chinese medi...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/74
CPCG01N30/06G01N30/74
Inventor 彭平迟玉明张京彦刘博譞常宇谷彩云
Owner DOJINDO
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