Hyaluronic acid microneedle patch and preparation method thereof

A technology of hyaluronic acid and micro-needle stickers, applied in the field of skin care products, can solve the problems of only staying on the surface of the skin, complicated formulas, and insignificant effects, and achieves the effect of natural color, reasonable compatibility and rich moisturizing effect.

Inactive Publication Date: 2019-07-23
胡婧 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many facial masks produced by hyaluronic acid in the market, but their formulas are complicated and the effect is not obvious. In terms of functional efficacy, they can only stay on the surface of the skin, making it difficult for the functional ingredients to enter the skin and play a better role. The question of efficacy

Method used

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  • Hyaluronic acid microneedle patch and preparation method thereof
  • Hyaluronic acid microneedle patch and preparation method thereof

Examples

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Effect test

Embodiment 1

[0033] This embodiment provides a hyaluronic acid microneedle patch, which includes the following raw materials in parts by weight: 5 parts of hyaluronic acid, 1 part of collagen, 15 parts of butanediol, 8 parts of arbutin, 2 parts of sodium ascorbyl phosphate, formazan Base isothiazolinone 0.01 part, deionized water 67 parts.

[0034] The preparation method comprises the following steps:

[0035] S1: Preparation of raw slurry: Weigh each raw material according to the ratio of parts by weight, put it into a vacuum emulsification pot, heat it to 50°C under stirring conditions, continue to stir until it dissolves evenly, and vacuumize and defoam to obtain the raw slurry;

[0036] S2: Forming: Put the original slurry obtained in step S1 into a mold, the mold is a female mold with an array of microneedle-shaped depressions on the surface, and the density of the microneedle-shaped depressions is 200 pieces / cm 2 , the needle tip height of the microneedle is 450 μm, the mold is put ...

Embodiment 2

[0040] This embodiment provides a hyaluronic acid microneedle patch, which includes the following raw materials in parts by weight: 10 parts of hyaluronic acid, 0.1 part of collagen, 10 parts of glycerol, 6 parts of sodium ascorbyl phosphate, and 0.02 parts of benzisothiazolinone parts, 70 parts of deionized water.

[0041] The preparation method comprises the following steps:

[0042] S1: Preparing the original slurry: Weigh each raw material according to the ratio of parts by weight, put it into a vacuum emulsification pot, heat it to 45°C under stirring conditions, continue to stir until it dissolves evenly, and perform vacuum degassing treatment to obtain the original slurry;

[0043] S2: Forming: Put the original slurry obtained in step S1 into a mold, the mold is a female mold with an array of microneedle-shaped depressions on the surface, and the density of the microneedle-shaped depressions is 170 pieces / cm 2 , the needle tip height of the microneedle is 400 μm, the m...

Embodiment 3

[0047] This embodiment provides a hyaluronic acid microneedle patch, which includes the following raw materials in parts by weight: 1 part of hyaluronic acid, 0.5 part of collagen, 20 parts of butanediol, 2 parts of arbutin, 2 parts of sodium ascorbyl phosphate, formazan Base isothiazolinone 0.01 part, deionized water 60 parts.

[0048] The preparation method comprises the following steps:

[0049] S1: Preparing the original slurry: Weigh each raw material according to the proportion by weight, put it into a vacuum emulsification pot, heat it to 55°C under stirring conditions, continue stirring until it dissolves evenly, and vacuumize and defoam to obtain the original slurry;

[0050] S2: Forming: Put the original slurry obtained in step S1 into a mold, the mold is a female mold with an array of microneedle-shaped depressions on the surface, and the density of the microneedle-shaped depressions is 150 pieces / cm 2 , the tip height of the microneedle is 500 μm, the mold is put ...

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Abstract

The invention relates to a hyaluronic acid microneedle patch. The hyaluronic acid microneedle patch comprises the following raw materials in parts by weight: 1-10 parts of hyaluronic acid, 0.1-2 partsof collagen, 10-20 parts of polyalcohol, 2-10 parts of functional active ingredients, 0.01-0.02 part of a preservative, and 60-80 parts of deionized water; and microneedle density of the hyaluronic acid microneedle patch is 140-220 pieces / cm<2> while tip height of the microneedles is 150-500 microns. The hyaluronic acid microneedle patch is capable of effectively piercing the stratum corneum so as to facilitate direct entering of the hyaluronic acid, the collagen and the functional active ingredients into the skin, thereby achieving significant skin-caring effects; moreover, the hyaluronic acid microneedle patch is non-irritative, free of side effects and high in safety. The invention further provides a preparation method of the hyaluronic acid microneedle patch. The preparation method ofthe hyaluronic acid microneedle patch is simple in processes; and the hyaluronic acid microneedle patch prepared by the preparation method is good in stability.

Description

technical field [0001] The invention relates to the field of skin care products, in particular to a hyaluronic acid microneedle patch and a preparation method thereof. Background technique [0002] Hyaluronic acid, scientific name hyaluronic acid (Hyaluronic acid, referred to as HA) or uronic acid, is a linear polymer polysaccharide composed of disaccharide units (glucuronic acid-N-ethylthioglucosamine). Substances that occur naturally in tissues. In nature, it widely exists in the connective tissue, mucus tissue, lens of the eyeball and some bacterial membranes of vertebrates, and plays an important role as a matrix in the dermis of human skin, whether it is the overall maintenance of the tissue structure or Transport between cells has a very important function. [0003] Hyaluronic acid not only has the function of maintaining skin elasticity, but also locks a large number of water molecules. It has a moisturizing and lubricating effect on tissues, making the skin plump, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/65A61K8/34A61K8/60A61K8/67A61K8/49A61Q19/00A61Q19/02A61Q19/08A61Q1/04A61M37/00
CPCA61K8/345A61K8/49A61K8/602A61K8/65A61K8/676A61K8/735A61K2800/43A61M37/0015A61M2037/0053A61Q1/04A61Q19/00A61Q19/02A61Q19/08
Inventor 胡婧吴敏
Owner 胡婧
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