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Novel application of traditional Chinese medicine composition to preparing kidney-Yang deficiency treating and preventing drugs

A composition and technology of kidney-yang deficiency, applied in a new application field in medicine, can solve the problems of blurred vision, increased light sensitivity, poor compliance, etc., and achieve the effects of increasing appetite, improving liver function, and correcting hormone levels in the body

Inactive Publication Date: 2019-07-26
吉林修正药业新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the disadvantages of large dosage, inconvenient, poor compliance, etc.
At present, there is no effective medicine for treating kidney-yang deficiency in western medicine. The main drug for erectile dysfunction is sildenafil, which has side effects such as headache, facial flushing, and indigestion. , blurred vision

Method used

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  • Novel application of traditional Chinese medicine composition to preparing kidney-Yang deficiency treating and preventing drugs
  • Novel application of traditional Chinese medicine composition to preparing kidney-Yang deficiency treating and preventing drugs
  • Novel application of traditional Chinese medicine composition to preparing kidney-Yang deficiency treating and preventing drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 1000g of the main medicine, 310g of Codonopsis pilosula, 310g of sealwort and 310g of woody fragrance, add water to decoct three times, combine the decoction, filter, concentrate the filtrate to an appropriate amount, spray dry it into powder, granulate with 80% ethanol, and after drying, crush into granules , mixed with 10g of vitamin C, compressed into 1000 tablets coated with sugar, to obtain tablets.

Embodiment 2

[0029] Take 1000g of the main medicine, 310g of Codonopsis pilosula, 310g of sealwort and 310g of woody fragrance, add water to decoct three times, combine the decoction, filter, concentrate the filtrate to an appropriate amount, spray dry it into powder, add 10g of starch and mix to make a capsule of 0.5g / capsule .

Embodiment 3

[0031] 1. Effects on pituitary-gonadal axis in rats with kidney-yang deficiency caused by hydrocortisone

[0032] 1.1 Modeling method

[0033] Except for 10 rats in the normal control group (equal volume of normal saline), the remaining 60 rats were intramuscularly injected with hydrocortisone 2.5mg / 100g, once a day, free to drink water and eat for 14 consecutive days, and replicated the kidney function. As an animal model of yang-deficiency rats, observe their activities, body weight, body hair gloss and shedding conditions to evaluate the modeling effect. The model rats showed obvious signs of "yang deficiency" such as loose hair, emaciation, listlessness, lack of movement and fear of cold. Successful model rats were randomly divided into kidney-yang deficiency model group, Shenbao tablet pill group (6.0g crude drug / kg), low, middle and high dose groups of Chinese medicine composition of embodiment 1 (2.0, 4.0, 8.0g crude drug / kg ): intragastric administration, 10ml / kg, 1 ...

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Abstract

The invention relates to the technical field of Chinese medicine, particularly to application of a traditional Chinese medicine composition to preparing kidney-Yang deficiency treating and preventingdrugs. The traditional Chinese medicine composition is composed of raw materials including, by weight part, 8-15 parts of herba swertiae, 2-5 parts of radix codonopsis, 2-5 parts of rhizoma polygonate, 2-5 parts of radix aucklandiae and 0.1-0.5 part of vitamin C. Experiment results show that the traditional Chinese medicine composition can significantly improve the level of T (testosterone), LH (luteinizing hormone), FSH (follicle-stimulating hormone) and GnRh (gonadotropin-releasing hormone) in the serum of a kidney-Yang deficiency model rat, increase the weight of the sexual organs of the rat, enhance SOD (superoxide dismutase) activity of testicular tissue homogenates, reduce the content of MDA (methylenedioxyamphetamine), increase the number and survival rate of sperms, and achieve a significant difference (P<0.05) compared with a kidney-Yang deficiency model group. The traditional Chinese medicine composition can achieve significant therapeutic effects on hypophysis-gonadal axis dysfunction and reproductive capacity reduction which are caused by kidney-Yang deficiency.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a new application of a traditional Chinese medicine composition in the preparation of medicines for treating and preventing kidney-yang deficiency. Background technique [0002] Kidney yang deficiency is the pathological change of weak kidney yang, warmth and weakness, abnormal qi transformation, endogenous yin and cold, and decreased sexual and reproductive ability. Deficiency of kidney yang means the decline and weakening of the vital functions of the human body. Clinically, the main manifestations are weakness of the waist and knees, chills and cold limbs, impotence and premature ejaculation. It is common in asthma, diarrhea, asthenia, edema, dysentery, impotence, leukorrhea, as well as chronic nephritis, chronic renal failure, chronic enteritis, adrenal hypofunction, chronic heart failure and other diseases in Western medicine. [0003] TCM syndromes ar...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P13/12A61P15/08A61P5/24A61K31/375
CPCA61K31/375A61K36/285A61K36/344A61K36/51A61K36/8969A61K2236/331A61K2236/39A61K2236/51A61P5/24A61P13/12A61P15/08A61K2300/00
Inventor 许艳茹徐建石菊展月宫海泉王宝成肖俊美
Owner 吉林修正药业新药开发有限公司
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