Application of notoginsenoside extract in preparation of medicinal preparation for eyes

A technology of Panax notoginseng saponins and extracts, applied in the application field of Panax notoginseng saponins extracts in the preparation of ophthalmic pharmaceutical preparations

Pending Publication Date: 2019-08-02
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no pharmaceutical preparations and new dosage forms using such natural product compositions for the prevention and treatment of ocular trauma, ocular vascular diseases and ocular neurological diseases through topical ocular administration.

Method used

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  • Application of notoginsenoside extract in preparation of medicinal preparation for eyes
  • Application of notoginsenoside extract in preparation of medicinal preparation for eyes
  • Application of notoginsenoside extract in preparation of medicinal preparation for eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This type of natural compound multi-dose eye drops (1)

[0031] Take 10 grams of this type of natural compound, dissolve it in 300 milliliters of normal saline, filter it with a 0.22 μm membrane, dilute to 1000 milliliters, seal it, sterilize it at high temperature, dispense it into eye drops bottles, each bottle is 10 milliliters, and get 100 drops eye drops.

Embodiment 2

[0033] This type of natural compound multi-dose eye drops (2)

[0034] Take 5 grams of this type of natural compound, dissolve it in 300 milliliters of normal saline, filter it with a 0.22 μm membrane, dilute to 1000 milliliters, seal it, sterilize it at high temperature, dispense it into eye drops bottles, each bottle is 10 milliliters, and get 100 drops eye drops.

Embodiment 3

[0036] This type of natural compound single-dose eye drops (1)

[0037] Take 10 grams of this type of natural compound, dissolve it in 300 milliliters of normal saline, filter it with a 0.22 μm membrane, dilute to 1000 milliliters, seal it, sterilize it at high temperature, dispense it into eye drops bottles, 0.4 milliliters per bottle, and get 25000 drops eye drops.

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PUM

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Abstract

The invention discloses application of a notoginsenoside extract in preparation of drugs for treating xerophthalmia, ocular injuries, ocular vascular disease or ocular neurogenic disease; the xerophthalmia, ocular injuries, ocular vascular disease or ocular neurogenic disease include but not limited to xerophthalmia, retina retrogressive disease, retinal vein obstruction, retinal periphlebitis, hyphema, vitreous hemorrhage, corneal injury, retinal contusion, glaucomatous optic atrophy, drusen, age-related macular degeneration and diabetic retinopathy. A mode of eye local drug delivery adoptedby the invention has the advantages of being low in dose, high in safety, less in adverse reaction, and good in patient compliance; the safety risk brought by injection delivery is avoided; furthermore, after changing the drug delivery route, the metabolic pathways, action mechanisms and other aspects thereof are different from the injection, and better clinical application prospect is realized.

Description

technical field [0001] The invention belongs to natural medicine technology, and in particular relates to the application of a notoginseng saponin extract in the preparation of ophthalmic pharmaceutical preparations. Background technique [0002] At present, improper use of eyes is common, and the incidence of dry eye syndrome is increasing; with the improvement of living standards, retinal vein occlusion, diabetic retinopathy, chorioretinopathy, age-related macular degeneration, glaucomatous optic atrophy and other blinding diseases It also seriously plagues the daily life of middle-aged and elderly people; although the incidence of ocular trauma such as anterior chamber hemorrhage and vitreous hemorrhage is not high, the pain and acute reaction they bring seriously affect the quality of life of patients. [0003] Modern studies have proved that ginsenosides and notoginseng saponins can significantly reduce platelet surface activity, inhibit platelet adhesion and aggregatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P27/02A61P17/02A61P9/14A61P9/10A61P25/02
CPCA61K36/258A61P27/02A61P17/02A61P9/14A61P9/10A61P25/02
Inventor 王真谭宁华唐锴
Owner CHINA PHARM UNIV
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