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Method for measuring lead and cadmium contents in human whole blood

A content and blood collection tube technology, applied in the field of trace element content detection, can solve the problems of large minimum quantitative limit, weak measurement signal, matrix interference, etc., and achieve the effect of strong specificity, high sensitivity and good reproducibility

Inactive Publication Date: 2019-08-02
沈阳和合医学检验所有限公司
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Problems solved by technology

[0003] At present, graphite furnace atomic absorption spectrometry is used to measure lead and cadmium in samples, but there are problems such as serious matrix interference, weak measurement signal, large error, and large lower limit of quantification.

Method used

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  • Method for measuring lead and cadmium contents in human whole blood
  • Method for measuring lead and cadmium contents in human whole blood
  • Method for measuring lead and cadmium contents in human whole blood

Examples

Experimental program
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Effect test

Embodiment 3

[0036] (1) Preparation of standard working solution

[0037] Use a pipette to pipette 4.5mL standard stock solution (100mg / L) and add 40.5mL 1% HNO3 solution, mix well to prepare 10mg / L Pb stock solution A, seal and store at 4°C in the dark, valid for 3 months.

[0038] Use a pipette to pipette 4.5mL standard stock solution (100mg / L) and add 40.5mL 1% HNO3 solution, mix well to prepare 10mg / L Cd stock solution B, seal and store at 4°C in the dark, valid for 3 months. Dilute the stock solutions A and B with 1% HNO3 solution, dilute them into 0.0625-2ug / L concentration of each standard song working solution, store at 4°C for later use, and have a validity period of 3 months.

[0039] (2) Preparation of internal standard working solution

[0040] Pipette 0.1mL bismuth (Bi), indium (In) single standard solution (1000mg / L) into 49.8mL 1% HNO3 solution, mix well, prepare 2mg / L internal standard stock solution C, seal and avoid The light is stored at 4°C for use, and the validity p...

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Abstract

The invention relates to the technical field of detecting the trace element content, in particular to a method for measuring lead and cadmium contents in the human whole blood. With an ICP-MS method,the lead and cadmium contents in the human whole blood are measured. The method comprises steps of pretreatment of a blood sample and the analysis of an ICP-MS. On the basis of the internal standard method, the lead and cadmium contents in a to-be-detected blood sample are quantified. According to the invention, on the basis of combination of the internal standard method with the ICP-MS method, the accuracy of the quantitative result is improved and the systematic error is eliminated, so that the detection process becomes simple and rapid; the contents of the trace elements in the human wholeblood sample can be reflected accurately; and thus the diagnosis of related diseases can be assisted and the reference for the clinical personalized medicine usage is provided.

Description

technical field [0001] The invention relates to the technical field of trace element content detection, in particular to a method for measuring the content of lead and cadmium in human whole blood. Background technique [0002] In recent years, the process of social industrialization has intensified, the impact on the environment has increased, and the ecological environment and water sources have been greatly polluted. Long-term exposure to cadmium and lead fumes in the growth environment is the main cause of chronic lead and cadmium poisoning. Detection of trace element lead and cadmium content has very important reference value for the prevention and control of related diseases. [0003] At present, graphite furnace atomic absorption spectrometry is used to measure lead and cadmium in samples, but there are problems such as serious matrix interference, weak measurement signal, large error, and large lower limit of quantification. Contents of the invention [0004] In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/72G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N30/7266G01N2030/045
Inventor 刘丽华刘莹隋文雯
Owner 沈阳和合医学检验所有限公司
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