A nerve cell protective agent and its application in the prevention and treatment of epilepsy

A technology of nerve cells and cells, which is applied in the field of oral tablets and epilepsy prevention and treatment, can solve the problems of easy sticking and punching of tablets, and achieve the solution of easy sticking and punching, significant social and economic significance, and beneficial to slow release Effect

Active Publication Date: 2021-07-23
AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to facilitate the clinical use of the drug, the present invention finally obtains a drug preparation with good stability through a large number of experimental studies, which solves the problem that sodium valproate and ethambutol hydrochloride have strong hygroscopicity and cause problems when tableting. The problem of easy sticking

Method used

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  • A nerve cell protective agent and its application in the prevention and treatment of epilepsy
  • A nerve cell protective agent and its application in the prevention and treatment of epilepsy
  • A nerve cell protective agent and its application in the prevention and treatment of epilepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the preparation of ethambutol hydrochloride-sodium valproate tablet

[0025] (1) Weigh 10 g of ethambutol hydrochloride, add 200 mL of water to prepare a solution, then add 12 g of kaolin, continue to stir to make it fully adsorbed and mix evenly, dry at 50 ° C at low temperature, and pass through a 20-mesh sieve to obtain ethylamine hydrochloride Butanol-containing granules;

[0026] (2) Take sodium valproate 125g, add in 2L75% ethanol solution and be mixed with solution, then add kaolin 180g, keep stirring to make it fully adsorb and mix evenly, dry, cross 20 mesh sieves, obtain sodium valproate drug-containing granules;

[0027] (3) Mix ethambutol hydrochloride drug-containing granules, sodium valproate drug-containing granules with 50 g of calcium hydrogen phosphate, 20 g of sodium carboxymethyl starch and 3.2 g of magnesium stearate, and directly compress into tablets. During the tableting process, there is no sticking phenomenon. Measure the relea...

Embodiment 2

[0028] Embodiment 2: the preparation of ethambutol hydrochloride-sodium valproate tablet

[0029](1) Weigh 12.5g of ethambutol hydrochloride, add 250mL water to prepare a solution, then add kaolin 15g, keep stirring to make it fully adsorb and mix evenly, dry at 50°C at low temperature, and pass through a 20-mesh sieve to obtain ethanol hydrochloride Ambutol-containing granules;

[0030] (2) Take sodium valproate 125g, add in 2L75% ethanol solution and be mixed with solution, then add kaolin 200g, keep stirring to make it fully adsorb and mix evenly, dry, cross 20 mesh sieves, obtain sodium valproate drug-containing granules;

[0031] (3) Mix ethambutol hydrochloride drug-containing granules, sodium valproate drug-containing granules with 60 g of calcium hydrogen phosphate, 25 g of sodium carboxymethyl starch and 3.5 g of magnesium stearate, and directly compress into tablets. During the tableting process, there is no sticking phenomenon. Measure the release rate of medicin...

Embodiment 3

[0032] Embodiment 3: the preparation of ethambutol hydrochloride-sodium valproate tablet

[0033] (1) Weigh 15g of ethambutol hydrochloride, add 300mL of water to prepare a solution, then add 15g of kaolin, keep stirring to make it fully adsorbed and mix evenly, dry at 50°C at low temperature, and pass through a 20-mesh sieve to obtain ethylamine hydrochloride Butanol-containing granules;

[0034] (2) Take sodium valproate 125g, add in 2L75% ethanol solution and be mixed with solution, then add kaolin 200g, keep stirring to make it fully adsorb and mix evenly, dry, cross 20 mesh sieves, obtain sodium valproate drug-containing granules;

[0035] (3) Mix ethambutol hydrochloride drug-containing granules, sodium valproate drug-containing granules with 60 g of calcium hydrogen phosphate, 25 g of carboxymethyl starch sodium and 3.8 g of magnesium stearate, and directly compress into tablets. During the tableting process, there is no sticking phenomenon. Measure the release rate ...

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Abstract

The invention discloses a pharmaceutical preparation for nerve cell protection. The pharmaceutical preparation is prepared from an active ingredient and a pharmaceutical auxiliary material, the active ingredient includes a pharmaceutically acceptable salt of ethambutol, the pharmaceutical auxiliary material includes kaolin, and the weight ratio of the active ingredient to kaolin is preferably 1:(1.3-2.5 ). The invention solves the problem that the medicine is easy to stick and rush when tableting due to its strong hygroscopicity, and at the same time enhances the stability of the preparation, and is beneficial to the slow release of the medicine in the body.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular relates to a solid oral preparation, in particular to an oral tablet for nerve cell protection and its application in the prevention and treatment of epilepsy. Background technique [0002] Epilepsy is a common neurological disease. It is a syndrome of chronic recurrent transient brain dysfunction, characterized by seizures caused by abnormal discharge of brain neurons. Among them, more than 30% of epilepsy patients are difficult to control their seizures with commonly used antiepileptic drugs in clinical practice, which is called intractable epilepsy. The pathogenesis of epilepsy is very complicated, and its entire mechanism has not been fully understood so far, but some important links of its pathogenesis have been discovered: the electrophysiological basis of epilepsy is highly synchronized abnormal discharge of neurons, and epilepsy is caused by The epilepto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/133A61K31/19A61K47/02A61K9/22A61P25/08
CPCA61K9/2009A61K31/133A61K31/19A61K47/02A61P25/08A61K2300/00
Inventor 王琳李扬宋进
Owner AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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