In-situ preparation and application method for povidone iodine-based antimicrobial micro-nano fiber dressing

Abstract

The invention discloses an in-situ preparation and application method for an povidone iodine-based antimicrobial micro-nano fiber dressing. The method comprises the steps that a high-molecular polymeris totally dissolved with absolute ethyl alcohol, and a high-molecular solution is prepared; an povidone iodine-based material is dissolved into the high-molecular solution and stirred until to be totally uniform, and a spinning precursor solution is obtained; the prepared spinning precursor solution is added into a syringe, the syringe is put into a portable electrostatic spinning device, the device is started, a spinning parameter is adjusted until fibers are uniformly sprayed out, the spacing distance between a sprayer mouth and a receiving wound is controlled, and then it can be achievedthat the antimicrobial nanometer fiber dressing can be prepared on the wound in situ. The preparation method can make the antimicrobial fiber film dressing perfectly fit the wound through the action of electrostatic force, and the nanometer fiber film is high in air permeability. Besides, povidone iodine is used as an antimicrobial component, the cost is low, the antimicrobial effect is good, andthe irritation of a common povidone iodine solution to the wound can be reduced. The in-situ preparation and application method is wide is application prospect.

Description

technical field

[0001] The invention belongs to the field of medical dressings, and in particular relates to a method for in-situ preparation and application of iodophor-based micro-nano fiber antibacterial dressings. Background technique

[0002] The skin is the largest organ of the human body and the first barrier of human body protection. It protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microorganisms, but it will be exposed to the external environment all the time. Causes different types of injuries, mainly acute (such as surgical and traumatic wounds, abrasions and burns) and chronic (such as diabetic foot ulcers and pressure ulcers). According to World Health Organization (WHO) estimates, there are approximately 41 million trauma cases worldwide each year, with an annual economic burden of more than $670 billion. Thus, human skin trauma imposes a considerable social and economic burden on healthcare systems worldwid...

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