Preparation methods of radix lithospermi silicone oil and radix lithospermi silicone oil composition preparation

A technology of comfrey silicone oil and composition, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of incomplete drug absorption, inconvenient application, etc., to improve bioavailability, easy to carry and use, and to avoid loss. live effect

Active Publication Date: 2019-08-16
CHONGQING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The comfrey oil sold in the market is viscous due to the extraction of oil substances, which is inconvenient to apply and the drug absorption is not complete

Method used

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  • Preparation methods of radix lithospermi silicone oil and radix lithospermi silicone oil composition preparation
  • Preparation methods of radix lithospermi silicone oil and radix lithospermi silicone oil composition preparation
  • Preparation methods of radix lithospermi silicone oil and radix lithospermi silicone oil composition preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This example provides a spray with comfrey husk and simethicone as the main raw materials. Simethicone is used to extract the main components of comfrey husk, and a water-bath extraction method is used to obtain a comfrey silicone oil extract. After dilution and packaging operations, purple Grass silicone oil composition spray.

[0026] The components of the comfrey silicone oil composition spray include 2200 parts of comfrey bark and 17600 parts of simethicone oil, calculated by weight fraction. 17600 parts of comfrey silicone oil, 8340 parts of diluent, 440 parts of flavoring agent, calculated in parts by volume.

[0027] This embodiment provides a preparation method of comfrey silicone oil composition spray, comprising the following steps:

[0028] (1) Dissolve the small pieces of bark grass bark in simethicone oil and soak them for a certain period of time according to the orthogonal test design, then extract in a water bath, and optimize the best extraction proces...

Embodiment 2

[0035] This example provides a spray with comfrey husk and simethicone as the main raw materials. Simethicone is used to extract the main components of comfrey husk, and a water-bath extraction method is used to obtain a comfrey silicone oil extract. After dilution and packaging operations, purple Grass silicone oil composition spray.

[0036] The components of the comfrey silicone oil composition spray include 2400 parts of comfrey bark and 19200 parts of simethicone oil, calculated by weight fraction. 19200 parts of comfrey oil, 9099 parts of diluent, 479 parts of flavoring agent, calculated in parts by volume.

[0037] This embodiment provides a preparation method of comfrey silicone oil composition spray, comprising the following steps:

[0038] (1) Dissolve the small pieces of bark grass bark in simethicone oil and soak them for a certain period of time according to the orthogonal test design, then extract in a water bath, and optimize the best extraction process to prep...

Embodiment 3

[0045] This example provides a spray that uses comfrey husk and simethicone as raw materials, uses simethicone to extract the main components of comfrey husk, obtains comfrey silicone oil extract by water bath extraction, and obtains comfrey through dilution and packaging operations Silicone oil composition spray.

[0046] The components of the comfrey silicone oil composition spray include 2700 parts of comfrey bark and 21600 parts of simethicone oil, calculated by weight fraction. 21600 parts of comfrey oil, 10237 parts of diluent, 539 parts of flavoring agent, in parts by volume.

[0047] This embodiment provides a preparation method of comfrey silicone oil composition spray, comprising the following steps:

[0048] (1) Dissolve the small pieces of comfrey bark in simethicone oil, soak them for a certain period of time according to the orthogonal experiment design, then extract them in a water bath, and optimize the best extraction process to prepare a solution to obtain the...

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Abstract

The invention discloses preparation methods of radix lithospermi silicone oil and a radix lithospermi silicone oil composition preparation. According to the preparation methods, levoalkannim in radixlithospermi is extracted by dimethyl silicone oil and is taken as an active ingredient, the active ingredient of the radix lithospermi is combined with the effects of skin moistening, heat clearing, inflammation diminishing and the like of silicone oil, and then appropriate amounts of diluent, flavoring agent, emulsifying agent and the like are added to prepare an external preparation like a radixlithospermi silicone oil composition spray or a radix lithospermi silicone oil composition ointment. The radix lithospermi silicone oil composition preparation is particularly suitable for preventionand treatment of diaper rash (red butt), skin eruptions, eczema and the like of an infant, can be used as a household standing kitchen supply to prevent and treat burns and scalds, and has the advantages of high stability, portability and convenience in use.

Description

technical field [0001] The invention relates to the field of preparation of comfrey silicone oil and its composition preparation, specifically preparing the comfrey silicone oil composition as spray or ointment. Background technique [0002] Comfrey oil is an oily traditional Chinese medicine liniment for external use. It has strong heat-clearing, detoxifying, antibacterial and anti-inflammatory effects. Comfrey contains shikonin naphthoquinones with strong fat solubility, and the effective substances mainly include acetylshikoninone, shikoninone, isobutyrylshikoninone, β,β-dimethylacryloylshikoninone, β -Hydroxyisovalerylshikonone and other active ingredients can inhibit the hyperpermeability of capillaries, and have antagonistic effects on inflammatory exudation, edema, and proliferative inflammation, because it can promote the proliferation of granulation tissue and promote wound healing. It is clinically used to treat I-II burns and eczema, etc. Due to the important po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/30A61K9/12A61K9/06A61K47/34A61P17/00A61P17/02
CPCA61K9/0014A61K9/06A61K9/12A61K36/30A61K47/34A61P17/00A61P17/02
Inventor 杨善彬王晴晴余龙宋明邹小慧肖荣明
Owner CHONGQING NORMAL UNIVERSITY
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