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Core-shell microneedle devices and uses thereof

A technology of microneedle and microneedle patch, which is applied in the direction of microneedle, needle, and other medical devices, and can solve long-term biocompatibility concerns and other issues

Active Publication Date: 2021-11-19
NORTH CAROLINA STATE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this formulation is limited by residual hydrogen peroxide in this system, raising concerns about long-term biocompatibility
In addition, simultaneous release of GOx and insulin may cause systemic toxicity

Method used

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  • Core-shell microneedle devices and uses thereof
  • Core-shell microneedle devices and uses thereof
  • Core-shell microneedle devices and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0207] Example 1: Core-shell microneedle gels for autoregulated insulin delivery.

[0208] result

[0209] TSPBA was synthesized by the quaternization of N1,N1,N3,N3-tetramethylpropane-1,3-diamine with excess 4-(bromomethyl)phenylboronic acid (Scheme 1). The quaternary ammonium groups on TSPBA greatly improved its water solubility (approximately 100 mg / mL), which facilitated the gel formation of PVA aqueous solution in the absence of organic solvents. in 10mM H 2 o 2 When oxidized in the presence, 70% of TSPBA liberated p-quinone methide (p-hydroxymethylenephenol) and converted to tertiary amine within 2 hours, as shown by H1-NMR analysis results (Fig. 7). [18] in DMSO and 10mM NaHCO 3 Insulin-NBC was prepared in the presence of a slight excess of NBC in a mixed solvent consisting of an aqueous solution. [19] Purified the product using preparative high-performance liquid chromatography (HPLC), [13] and used MALDI-TOF mass spectrometry to confirm that the product was a con...

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Abstract

The present disclosure relates to microneedle devices and methods for treating diseases (eg, diabetes) using degradable cross-linked gels for autoregulated delivery of therapeutic agents (eg, insulin).

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application Serial No. 62 / 430,260, filed December 5, 2016, the disclosure of which is expressly incorporated herein by reference. technical field [0003] The present disclosure relates to microneedle devices and methods for treating diseases (eg, diabetes) using degradable cross-linked gels for autoregulated delivery of therapeutic agents (eg, insulin). Background technique [0004] Diabetes mellitus is a chronic disease affecting 422 million people worldwide in 2016, characterized by a deficiency of endogenously produced insulin and elevated blood glucose levels (BGL). Without proper control, chronically elevated BGL can lead to amputation, blindness, kidney failure, and cardiovascular disease. To prevent these diabetic complications, patients with advanced type 1 and type 2 diabetes often fail to achieve euglycemic goals with injected or infused insulin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61K9/00A61K47/54A61K47/69A61K38/28A61K38/44A61K31/728A61P3/10
CPCA61K38/28A61K47/54A61P3/10A61K9/0021A61M37/0015A61M2037/0046A61M2037/0061A61K38/44C12Y101/03004C12Y111/01006A61K47/6955A61K31/728A61K2300/00
Inventor 顾震J·王叶彦奇
Owner NORTH CAROLINA STATE UNIV