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A kind of chromatographic purification method of Quina bark alcohol

A technology for the purification of quebranol and its purification method, which is applied in the field of extraction and separation of natural products, can solve the problems of complicated purification process operation, difficult industrial production, and low output of quebranol, and achieve the effect of overcoming the low yield

Active Publication Date: 2020-11-10
HAINAN ZHONG XIANG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are a large number of reports about the extraction research of Quina bark alcohol at present, the method for extracting Quina cortex alcohol from the rubber-making wastewater usually adopts chromatographic extraction, but the purification process of the existing chromatography is complicated to operate, and The most important thing is that the yield of extracted quinia cortex is low, and it is difficult to be suitable for industrialized production. Therefore, how to realize the industrialization of the quinia cortex extraction process and how to improve the extraction of quinia cortex while ensuring the purity rate is a hot topic of research

Method used

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  • A kind of chromatographic purification method of Quina bark alcohol

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Embodiment 1

[0030] Embodiment 1-a kind of chromatographic purification method of Quina bark alcohol, comprises the steps:

[0031] (1) Pretreatment of rubber wastewater

[0032] Heat the gel-making waste water to 90°C, add calcium oxide, filter to remove floating glue, flocs and solid impurities, and obtain the initial liquid; evaporate and concentrate the filtrate to 1 / 3 of the original volume to obtain the concentrated initial liquid;

[0033] (2) Activated carbon decolorization

[0034] Cool and filter the concentrated initial solution, pass the filtrate through a chromatographic column equipped with powdered activated carbon, elute with 3 times the column volume of deionized water, and collect the effluent from the activated carbon column;

[0035] (3) Macroporous resin adsorption

[0036] Weigh the polar resins HPD400, HPD600 and D145 with a mass ratio of 3:2:1 and place them in a stoppered Erlenmeyer flask, add activated carbon column effluent, wherein the polar resins HPD400, HPD...

Embodiment 2

[0041] Embodiment 2-a kind of chromatographic purification method of Quina cortex alcohol, comprises the steps:

[0042] (1) Pretreatment of rubber wastewater

[0043] Heat the gel-making waste water to 100°C, add calcium oxide, filter to remove floating glue, flocs and solid impurities, and obtain the initial liquid; evaporate and concentrate the filtrate to 1 / 6 of the original volume to obtain the concentrated initial liquid;

[0044] (2) Activated carbon decolorization

[0045] Cool and filter the concentrated initial solution, pass the filtrate through a chromatographic column equipped with powdered activated carbon, elute with 4 times the column volume of deionized water, and collect the effluent from the activated carbon column;

[0046] (3) Macroporous resin adsorption

[0047]Weighing polar resins HPD400, HPD600 and D145 with a mass ratio of 3:3:1 were placed in a stoppered Erlenmeyer flask, and the activated carbon column effluent was added, wherein the total mass o...

Embodiment 3

[0052] Embodiment 3-a kind of chromatographic purification method of Quina cortex alcohol, comprises the steps:

[0053] (1) Pretreatment of rubber wastewater

[0054] Heat the gel-making waste water to 100°C, add calcium oxide, filter to remove floating glue, flocs and solid impurities, and obtain the initial liquid; evaporate and concentrate the filtrate to 1 / 5 of the original volume to obtain the concentrated initial liquid;

[0055] (2) Activated carbon decolorization

[0056] Cool and filter the concentrated initial solution, pass the filtrate through a chromatographic column equipped with powdered activated carbon, elute with 3 times the column volume of deionized water, and collect the effluent from the activated carbon column;

[0057] (3) Macroporous resin adsorption

[0058] The polar resins HPD400, HPD600 and D145 with a mass ratio of 2:2:1 were weighed respectively and placed in a stoppered Erlenmeyer flask, and the activated carbon column effluent was added, whe...

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Abstract

The invention provides a chromatography purification method for L-quebrachitol. The chromatography purification method comprises the following steps: (1) pretreating glue making wastewater so as to obtain a concentrated primary liquid; (2) cooling and filtering the concentrated primary liquid, and eluting filtrate through a chromatographic column filled with powdered activated carbon; (3) respectively weighing polar resins HPD400, HPD600 and D145 in a mass ratio of (3-2):(3-2), adding an activated carbon effluent, carrying out constant-temperature water bath oscillation at 100-120r / minute at 23-26 DEG C for 3-5 hours, leaving to stand, carrying out vacuum suction filtration, and putting 2-4 times of a methanol and n-propyl alcohol mixed solution into the resins so as to obtain an extract;(4) feeding the extract through a chromatographic column filled with silica gel of 100-300 meshes, eluting with a flow phase of the methanol and n-propyl alcohol mixed solution, and collecting an eluant; (5) carrying out vacuum concentration on the eluant at 80 DEG C or less, cooling the concentrated liquid to separate a crystal, recrystallizing for 2-3 times, thereby obtaining the L-quebrachitol.The chromatography purification method for L-quebrachitol, which is provided by the invention, is high in extraction purity, the extraction rate is greatly increased, and a industrialized chromatography extraction process of L-quebrachitol can be achieved.

Description

technical field [0001] The invention relates to the technical field of extraction and separation of natural products, in particular to a chromatographic purification method for quebranol. Background technique [0002] L-Quebrachitol is L-inositol methyl ether, chemical name: [2-0-methy1-L(-)-chiro-inositol], is a natural optically active inositol widely present in plants , It has been confirmed that Quina cortisol plays an important role in the metabolism of living organisms, "transmitting information inside the cell" and "controlling the process of cell growth". As a chiral structural unit, it can simply convert Quina Cortisol into a variety of inositol derivatives that are widely used in biology and medicine. Therefore, Quina Cortitol has attracted the attention of biochemical, pharmaceutical and medical experts. [0003] Although there are a large number of reports about the extraction research of Quina bark alcohol at present, the method for extracting Quina cortex alco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C41/36C07C41/40C07C43/196
CPCC07C41/36C07C41/40C07C2601/14C07C43/196
Inventor 张艺丁小芳丁爱武李德新张毅超陈君兴
Owner HAINAN ZHONG XIANG TECH CO LTD
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