Method for preparing nano hydroxyapatite powder

Abstract

The invention relates to a method for preparing nano hydroxyapatite powder, belonging to the field of the biomedical material. The method for preparing the nano hydroxyapatite powder comprises the following steps: adding the organic polymer of polyethylene glycol to the initial reactants of calcium nitrate and diammonium phosphate solution to adjust and control the morphologies of the products ofreaction; adding aqueous ammonia to adjust the pH values of the products of reaction, and making the aqueous ammonia react with the products of reaction at different water bath temperature to synthesize nano hydroxyapatite precipitate, wherein the agglomeration of the synthesized nano hydroxyapatite precipitate can be inhibited by the polyethylene glycol functioning as the dispersant; freezing and drying synthesized nano hydroxyapatite precipitate slurry to obtain dry nano hydroxyapatite powder which contains by-products of reaction and polyethylene glycol, and calcinating the dry nano hydroxyapatite powder at high temperature to remove the by-products of reaction and the polyethylene glycol which are contained in the dry nano hydroxyapatite powder to obtain the nano hydroxyapatite powderwhich is in the shape of the ball or the rod and in the particle size of 10-100 nm and has high yield and good dispersion. The method for preparing the nano hydroxyapatite powder is simple, needs short preparing period, causes no poison and pollution and is suitable for industrial production.

Description

Technical field:

[0001] The invention relates to biomedical material preparation technology, in particular to a method for preparing nano-hydroxyapatite powder, which belongs to the field of biomedical materials. Background technique:

[0002] Hydroxyapatite is the main inorganic component of human bones and teeth, and has good biocompatibility and bioactivity. It has been widely used as bone defect filling material, bone cement, artificial joint coating plasma spraying material, hard tissue replacement material, tissue engineering scaffold, etc. At the same time, nano-hydroxyapatite with a particle size of less than 100nm has special mechanical and biological properties due to its high surface energy, large specific surface area, and properties that are closer to the particle size of hydroxyapatite in natural bone. Studies have shown that nanoscale hydroxyapatite can penetrate the liver tumor cell membrane and enter the cell interior to induce apoptosis of liver tumor cell...

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