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Method for preparing nano hydroxyapatite powder

A nano-hydroxyapatite and powder technology, which is applied in the field of biomedical materials, can solve the problems of long production cycle, cumbersome process, and low output, and achieve a narrow particle size distribution, good biocompatibility, and good dispersibility. Effect

Inactive Publication Date: 2011-06-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problems existing in the existing technology of preparing nano-hydroxyapatite powder, and to provide a preparation of nano-hydroxyapatite powder with simple process, short production cycle, high yield and good dispersibility. A new method; to overcome the defects of the existing technology such as cumbersome procedures, long production cycle, and low output

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  • Method for preparing nano hydroxyapatite powder

Examples

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Effect test

Embodiment 1

[0030] At room temperature, weigh 11.80g calcium nitrate (Ca(NO 3 ) 2 4H 2 (2) Polyethylene Glycol 15.00g with molecular weight 6000, they are dissolved with deionized water and transferred to 50ml volumetric flask and constant volume to scale, get the composite solution of calcium nitrate and Polyethylene Glycol; Wherein said calcium nitrate and The concentration of calcium nitrate in the polyethylene glycol composite solution is 1.00mol / L, and the polyethylene glycol mass fraction is 30%; then 50.00ml of the composite solution is transferred to a 250ml four-necked bottle and continuously stirred in a water bath at 10°C ; After the temperature of the composite solution reaches 10°C, use 0.1ml ammonia water (NH 3 ·H 2 O) Adjust its pH to 10.0. Then at room temperature, weigh 3.96g diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ), was dissolved in deionized water and transferred to a 50ml volumetric flask and fixed to the mark to prepare diammonium hydrogen phosphate ((N...

Embodiment 2

[0032] At room temperature, weigh 1.18g of calcium nitrate and 5.00g of polyethylene glycol with a molecular weight of 2000, dissolve them with deionized water and transfer them to a 50ml volumetric flask and set the volume to the mark to obtain calcium nitrate and polyethylene glycol. Composite solution; Calcium nitrate concentration is 0.10mol / L in wherein said calcium nitrate and polyethylene glycol composite solution, and described polyethylene glycol mass fraction is 10%; Then this composite solution of 40.00ml is transferred to 250ml four-neck bottle and keep stirring in a water bath at 25°C; when the temperature of the composite solution reaches 25°C, adjust its pH to 11.0 with 2.0ml of ammonia water. Then at room temperature, take by weighing 0.40g diammonium hydrogen phosphate, dissolve it with deionized water and transfer it to a 50ml volumetric flask and settle to the mark to prepare diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ) solution, the concentration of w...

Embodiment 3

[0034] At room temperature, take by weighing 59.04g of calcium nitrate and 10.00g of polyethylene glycol with a molecular weight of 10000, dissolve them with deionized water and transfer to a 50ml volumetric flask and settle to the mark to obtain calcium nitrate and polyethylene glycol Composite solution; Calcium nitrate concentration is 5.00mol / L in wherein said calcium nitrate and polyethylene glycol composite solution, and described polyethylene glycol mass fraction is 20%; Then this composite solution of 45.00ml is transferred to 250ml four-neck bottle and keep stirring in a water bath at 15°C; when the temperature of the composite solution reaches 15°C, adjust its pH to 11.0 with 1.0ml of ammonia water. Then at room temperature, take by weighing 19.82g of diammonium hydrogen phosphate, dissolve it with deionized water and transfer to a 50ml volumetric flask and settle to the mark to prepare diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ) solution, the concentration of ...

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Abstract

The invention relates to a method for preparing nano hydroxyapatite powder, belonging to the field of the biomedical material. The method for preparing the nano hydroxyapatite powder comprises the following steps: adding the organic polymer of polyethylene glycol to the initial reactants of calcium nitrate and diammonium phosphate solution to adjust and control the morphologies of the products ofreaction; adding aqueous ammonia to adjust the pH values of the products of reaction, and making the aqueous ammonia react with the products of reaction at different water bath temperature to synthesize nano hydroxyapatite precipitate, wherein the agglomeration of the synthesized nano hydroxyapatite precipitate can be inhibited by the polyethylene glycol functioning as the dispersant; freezing and drying synthesized nano hydroxyapatite precipitate slurry to obtain dry nano hydroxyapatite powder which contains by-products of reaction and polyethylene glycol, and calcinating the dry nano hydroxyapatite powder at high temperature to remove the by-products of reaction and the polyethylene glycol which are contained in the dry nano hydroxyapatite powder to obtain the nano hydroxyapatite powderwhich is in the shape of the ball or the rod and in the particle size of 10-100 nm and has high yield and good dispersion. The method for preparing the nano hydroxyapatite powder is simple, needs short preparing period, causes no poison and pollution and is suitable for industrial production.

Description

Technical field: [0001] The invention relates to biomedical material preparation technology, in particular to a method for preparing nano-hydroxyapatite powder, which belongs to the field of biomedical materials. Background technique: [0002] Hydroxyapatite is the main inorganic component of human bones and teeth, and has good biocompatibility and bioactivity. It has been widely used as bone defect filling material, bone cement, artificial joint coating plasma spraying material, hard tissue replacement material, tissue engineering scaffold, etc. At the same time, nano-hydroxyapatite with a particle size of less than 100nm has special mechanical and biological properties due to its high surface energy, large specific surface area, and properties that are closer to the particle size of hydroxyapatite in natural bone. Studies have shown that nanoscale hydroxyapatite can penetrate the liver tumor cell membrane and enter the cell interior to induce apoptosis of liver tumor cell...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82B3/00
Inventor 张怀法范红松张兴栋
Owner SICHUAN UNIV
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