A kind of preparation method of porous material reinforced bletilla striata dressing

A porous material, Bletilla striata technology, which can be used in pharmaceutical formulations, bandages, drug delivery, etc., and can solve the problems of easy adhesion, difficult detachment, and limited application scope of dressings.

Active Publication Date: 2021-09-21
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But because the bletilla striata polysaccharide is very soluble in water, it is easy to adhere and difficult to detach during operation, so it cannot be well attached to the wound during use.
[0004] The existing Bletilla striata dressing will dissolve and stick due to the blood on the gloves worn by doctors during surgical operations, making it difficult for the Bletilla striata dressing to be applied to the wound at one time
The operating layer of traditional multi-layer dressings is non-degradable, which greatly limits the application range of dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] A kind of porous material strengthens the preparation method of bletilla striata base dressing, described preparation method is carried out according to the following steps:

[0026] a Preparation of Bletilla striata polysaccharide casting solution

[0027] The bletilla striata polysaccharide solution is prepared by dissolving the bletilla striata polysaccharide in water to prepare a bletilla striata polysaccharide solution with a mass fraction of 3-10%, and placed in a vacuum state with a vacuum degree of 0.1-0.5 MPa to remove air bubbles to obtain a bletilla striata polysaccharide casting solution for future use.

[0028] b. Preparation of bletilla striata polysaccharide solution

[0029] The bletilla striata polysaccharide solution is prepared by dissolving the bletilla striata polysaccharide in water to prepare a bletilla striata polysaccharide solution with a mass fraction of 10-15%, and placed in a vacuum state with a vacuum degree of 0.1-0.5 MPa to remove air bub...

Embodiment 1

[0037] a Preparation of Bletilla striata polysaccharide casting solution

[0038] Dissolving Bletilla striata polysaccharide in water to prepare a Bletilla striata polysaccharide solution with a mass fraction of 3%, and placing it in a vacuum with a degree of vacuum of 0.1 MPa to remove air bubbles to obtain a Bletilla striata polysaccharide casting solution for future use.

[0039] b. Preparation of bletilla striata polysaccharide solution

[0040] Dissolving Bletilla striata polysaccharide in water to prepare a Bletilla striata polysaccharide solution with a mass fraction of 10%, and placing it in a vacuum state with a vacuum degree of 0.1 MPa to remove air bubbles to obtain a Bletilla striata polysaccharide solution for the connecting layer.

[0041] c Porous material strengthens the preparation of bletilla striata dressing

[0042] Pour the Bletilla striata polysaccharide casting solution prepared in step a into the groove of the flat mold, and set a metal conductor for t...

Embodiment 2

[0046] a Preparation of Bletilla striata polysaccharide casting solution

[0047] Dissolving Bletilla striata polysaccharide in water to prepare a Bletilla striata polysaccharide solution with a mass fraction of 5%, and placing it in a vacuum state with a vacuum degree of 0.2 MPa to remove air bubbles to obtain a Bletilla striata polysaccharide casting solution for future use.

[0048] b. Preparation of bletilla striata polysaccharide solution

[0049] Dissolving Bletilla striata polysaccharide in water to prepare a Bletilla striata polysaccharide solution with a mass fraction of 13%, and placing it in a vacuum state with a vacuum degree of 0.3 MPa to remove air bubbles to obtain a Bletilla striata polysaccharide solution for the connecting layer.

[0050] c Porous material strengthens the preparation of bletilla striata dressing

[0051] Pour the bletilla striata polysaccharide casting solution prepared in step a into the groove of the flat mold, and set a metal conductor fo...

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PUM

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Abstract

The invention relates to a preparation method of porous material reinforced bletilla striata dressing, which belongs to the technical field of biomedicine. The preparation method uses directional freezing of part of the Bletilla striata polysaccharide casting solution, pours the bletilla striata polysaccharide solution of the connecting layer on the upper part of the incompletely frozen Bletilla striata polysaccharide casting solution, and spreads insoluble gelatin sponge or medical oxidized cellulose on the top of the melted solution Gauze, under the action of the metal conductor, the porous material, the bletilla striata polysaccharide solution in the connecting layer and the bletilla striata polysaccharide casting solution are frozen into one, and then the porous material reinforced bletilla striata dressing is obtained through freeze-drying technology, which solves the problem that the existing bletilla striata dressing is easy to use in clinical medicine. It is soluble in water and difficult to stick to the wound. The materials used in the preparation method of the invention can all be degraded and absorbed, and are non-toxic to human bodies. The preparation method of the invention enhances the mechanical properties and operational performance of the bletilla striata dressing, and promotes the application of the bletilla striata dressing in the fields of surgery, wound repair, tissue engineering and the like.

Description

technical field [0001] The invention relates to a preparation method of porous material reinforced bletilla striata dressing, which belongs to the technical field of biomedicine. Background technique [0002] In the clinical use of surgery, the rapid hemostasis of the wound has an important impact on the postoperative recovery of patients. Bletilla striata polysaccharide has the functions of antibacterial and anti-inflammatory, removing putrefaction and promoting granulation, astringent sores, etc., and has no toxic and side effects, is safe and comfortable, degradable, non-polluting, and has good biocompatibility. It is a good natural bioengineering material and can be used as a drug dressing in pharmaceutical preparations. [0003] The Chinese patent publication number is CN102477102A, the publication date is May 12, 2012, and the title of the invention is a method for using bletilla striata polysaccharides as a hemostatic material. The invention uses bletilla striata pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46A61L15/62
CPCA61L15/28A61L15/32A61L15/42A61L15/425A61L15/44A61L15/46A61L15/62A61L2300/232A61L2300/404A61L2300/41A61L2300/412A61L2400/04C08L89/00C08L1/04
Inventor 杨红军王晗许愿刘昌俊张骞陈欣庄燕徐卫林
Owner WUHAN TEXTILE UNIV
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