Application of a kind of sweet leaf or tuber extract in the preparation of antidepressant medicine

A technology of stem extract and fragrant leaf, which is applied to the application field of fragrant leaf or tuber extract in the preparation of antidepressant drugs, can solve the problems of in-depth research on undiscovered chemical components and pharmacological activity, and achieves no dose dependence. Sexuality, significant antidepressant activity, increased sugar water consumption

Active Publication Date: 2021-09-28
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, no in-depth research on its chemical composition and pharmacological activity has been found

Method used

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  • Application of a kind of sweet leaf or tuber extract in the preparation of antidepressant medicine
  • Application of a kind of sweet leaf or tuber extract in the preparation of antidepressant medicine
  • Application of a kind of sweet leaf or tuber extract in the preparation of antidepressant medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] A preferred embodiment of the present invention provides an extract of leaves or tubers.

[0032] Wherein, the extract of the leaves or tubers of the fragrant leaves or the tubers is the ethanol extract of the leaves or the tubers of the fragrant leaves. The preparation method of the leaves or tuber extracts of the leaves or tubers is as follows:

[0033] Take 300g of air-dried leaves or tubers, pulverize them with a pulverizer, and soak them with 95% ethanol for 4 times at room temperature, each time for 6 days, to obtain the extracts soaked for 4 times respectively; Rotary evaporator distilled under reduced pressure, and concentrated to obtain 43.7g of the extract of the leaves or tubers of the leaves or tubers.

[0034] Dissolve the Leaf extract in 5vt% sodium carboxymethylcellulose solution to make 113.08mg / mL, 56.54mg / mL, and 28.27mg / mL solutions for the high-dose group, respectively.

experiment example 1

[0036] Experimental animals: 120 male Kunming mice, weighing 18-22g. Before the start of the experiment, the diet and water conditions were not restricted, and they were adaptively raised in the experimental environment for 7 days.

[0037] Experimental preparation: After 7 days of adaptive feeding, the weight of the mice was weighed, and the mice with large differences were removed. The remaining mice meeting the criteria were randomly divided into blank group (GC), model group (MG), positive group (FXT), high-dose group of fragrant leaves (XH), middle-dose group of fragrant leaves (XM), low-dose group of fragrant leaves (XL), 12 per group. During the experiment, the body weight of the mice was weighed and recorded every two weeks.

[0038] Establishment of the mouse depression model (CUMS method): refer to Willner P's chronic mild unforeseen stress plus orphanage to reproduce the depression model, and the mice in each group except the blank group were isolated, one in a ca...

experiment example 2

[0048] Detect the contents of serum CORT, 5-HT and NE in the hippocampus of mice, and study the antidepressant mechanism of the extracts of leaves or tubers.

[0049] Experimental animals, experimental preparations and mouse depression model establishment are the same as in Experimental Example 1.

[0050] After the last administration, the blood was taken quickly from the eyeball, and the blood was left to stand for 2 hours, centrifuged at 3000r / min for 10 minutes, and the serum was separated for direct detection of CORT; after the blood was taken from the eyeball, the mice were quickly killed by decapitation. The head was dissected on an ice tray, the brain was quickly peeled off, the blood on the surface was rinsed with ice saline, and the water was then blotted with filter paper. The bilateral brains were separated along the sagittal suture, and the hippocampal tissues on both sides were peeled off and weighed separately. Pre-cooled PBS was used to wash away residual bloo...

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Abstract

The invention discloses the application of an extract of leaves or tubers of Cymbidium in the preparation of antidepressant drugs. The invention prepares an ethanol extract of leaves or tubers of Cymbidium, after taking air-dried leaves or tubers of Cymbidium and pulverizing them, the Soaked in ethanol, then distilled under reduced pressure, and concentrated to obtain the extract of leaves or tubers. By analyzing the effect of the leaves or tubers of the leaves or tubers on the depression-like behaviors and neurotransmitters of mice, the antidepressant effect is studied, and the application of the leaves or tubers of the leaves or tubers in the preparation of antidepressants is realized.

Description

technical field [0001] The invention belongs to the technical field of medicinal use of fenugreek leaves, and in particular relates to the application of an extract of fennel leaves or tubers in the preparation of antidepressants. Background technique [0002] Depression is a common mental disorder characterized by persistent mental disorders. Patients are often accompanied by chronic sadness and helplessness, and severe depression can lead to suicide. In addition, depression also increases the risk of coronary artery disease and diabetes. According to the statistics of the World Health Organization, more than 300 million people around the world suffer from depression, and it continues to grow at an annual rate of 18%. Yet less than half of people with depression receive effective treatment. Despite its prevalence, depression's physiology and pathology are still in its infancy compared with other chronic and underlying diseases. At present, traditional antidepressants ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/54A61P25/24A61K127/00A61K125/00
CPCA61K36/54A61K2236/333A61K2236/39A61K2236/51A61P25/24
Inventor 蒋合众甘甜蒋明昆谭睿闫智勇李加洪李瑶王乐王姝
Owner SOUTHWEST JIAOTONG UNIV
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