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Antitumor slow-release implant having strong adhesion and hemostasis functions and preparation method thereof

A slow-release implant and anti-tumor technology, which is applied in the direction of anti-tumor drugs, medical preparations with no active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of easy metastasis of cancer cells, easy bleeding of wounds, and easy inflammation and other problems, to achieve the effect of stable self-healing performance, beneficial to clinical application, and good injection performance

Active Publication Date: 2019-09-20
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide an anti-tumor slow-release implant with strong adhesion and hemostatic function, so as to solve many problems such as wound bleeding, infection, inflammation, and cancer cell metastasis in traditional cancer surgery. Apply implants to irregular tumor wounds, and at the same time perform mild thermotherapy to prevent postoperative recurrence of tumors

Method used

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  • Antitumor slow-release implant having strong adhesion and hemostasis functions and preparation method thereof
  • Antitumor slow-release implant having strong adhesion and hemostasis functions and preparation method thereof
  • Antitumor slow-release implant having strong adhesion and hemostasis functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of a non-drug-loaded anti-tumor sustained-release implant with strong adhesion and hemostatic functions

[0048] Chitosan (1.3104 g, 8 mmol) and 1-hydroxybenzotriazole monohydrate (1.1480 g, 8 mmol) were dissolved in 100 mL of deionized water, and stirred overnight until the solution was clear and transparent. 40mL of gallic acid solution (0.3872g, 2mmol) was added dropwise in the chitosan solution, and then 2mL of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride was added dropwise. Ethanol solution (0.3437g, 2mmol). The mixed system was reacted for 24 hours at room temperature (25° C.) and protected from light. After the reaction, the reactant was poured into a dialysis bag (MWCO 14000Da), and dialyzed at 37° C. for 16 hours under nitrogen protection, and the water in the dialysis system was changed every 2 hours. After the dialysis is completed, the obtained product is freeze-dried to obtain a gallic acid-grafted chitosan copolymer, ...

Embodiment 2

[0055] Example 2: Preparation of an anti-tumor sustained-release implant loaded with doxorubicin with strong adhesion and hemostatic functions

[0056] The CSG precursor was prepared in the same manner as in Example 1.

[0057] Weigh 30 mg of lyophilized CSG precursor, dissolve it in 900 μL of 360 μg / mL doxorubicin hydrochloride solution, and after ultrasonic stirring for 10 min, add 100 μL of FeCl 3 ·6H 2 O (25mM) solution, after ultrasonication for 30 minutes, an anti-tumor sustained-release implant loaded with doxorubicin with strong adhesion and hemostatic functions was obtained.

[0058] MDL-III-808-2 laser and Fluke TI400IR thermal imager were used to evaluate the photothermal performance of the anti-tumor sustained-release implant (1mL) loaded with doxorubicin in this embodiment, which has strong adhesion and hemostatic functions, and at the same time Taking aqueous solution as a control, the Figure 10 It can be seen that the implant has good photothermal conversion...

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Abstract

The invention discloses an antitumor slow-release implant having strong adhesion and hemostasis functions and a preparation method thereof. Inspired by mussel adhesion mechanism and catechol and iron ion chelating mechanism, postoperative thermal chemotherapy hydrogel based on mussel adhesion mechanism deriving is developed successfully through bionic design and serves as a multifunctional operative tissue adhesion and treatment agent. Main ingredients of the implant include chitosan, gallic acid, Fe3+ chelating agent and drug. Coating and treating of a wound can be performed by covalently crosslinking and freeze-drying chitosan and gallic acid, dissolving before use, adding antitumor drug, utilizing the Fe3+ chelating agent for crosslinking and ultrasonically mixing well to form gel. The implant has various functions of adhesion, hemostasis, bacteria resisting, inflammation diminishing and thermal chemotherapy of the wound, and postoperative relapse prevention of tumor can be realized by coating an irregular wound of the tumor with the implant and performing mild thermal chemotherapy.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation and biomedicine, and specifically relates to an anti-tumor slow-release implant with strong adhesion and hemostatic functions and a preparation method thereof. Background technique [0002] At present, although various emerging cancer treatment methods have achieved good therapeutic effects in animal models, surgery is still one of the main means of clinical cancer treatment, which mainly saves patients by removing primary or even metastatic tumors s life. However, irregular tumor margins, blurred boundaries between normal and tumor tissues, and difficulty in distinguishing important tissue regions for tumor growth and invasion all lead to incomplete tumor resection, further leading to tumor recurrence. Secondly, surgical resection wounds are prone to bleeding, infection, and cancer cell metastasis, which is also one of the important reasons why patients with tumor resection cannot continu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/12A61K41/00A61K31/704A61P35/00
CPCA61K9/06A61K9/0024A61K47/36A61K47/12A61K41/0052A61K31/704A61P35/00A61K2300/00Y02A50/30
Inventor 查正宝贺港陆杨缪昭华马艳
Owner HEFEI UNIV OF TECH
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