Method for preparing medical transparent hydrogel eye patch through physical irradiation double-crosslinking approach

Abstract

The invention discloses a method for preparing a medical transparent hydrogel eye patch through a physical irradiation double-crosslinking approach. According to the method, a polyvinyl alcohol aqueous solution is maintained in a semi-gel state by means of a physical method with shorter freezing time and lower freezing frequency, and then a semi-gel product is subjected to irradiation crosslinking. Not only is the phenomenon that gel is turbid and opaque due to pure physical crosslinking avoided, but also the problem that aqueous solution products cannot be normally transported due to pure irradiation crosslinking is avoided. The glasses-simulated appearance of the eye patch accords with the principle of human engineering, the eye patch is properly adhered to the skin of the eyes and is in a transparent film shape, and the eye condition of a patient can be observed clinically at any time. The eye patch has good moisture retention performance and high biocompatibility, is safe and free of adverse reactions, physically isolates the eyes in an operation process, enables the eyes to stay in a relatively sealed moist environment when the eyes are covered, and has the effects of moistening the cornea of the eyes and effectively preventing exposure keratitis.

Description

technical field [0001] The invention relates to a method for preparing a medical transparent hydrogel eye patch by a physical and radiation double cross-linking method. Background technique [0002] Polyvinyl alcohol (PVA) is a biodegradable polymer material containing a large number of hydroxyl groups in a synthetic molecule. It is a three-dimensional network polymer formed by chemical cross-linking bonds or physical forces. Its characteristic is that it can absorb solvent water and swelling. The hydrogel prepared from it is a gel with water as the medium, which is a polymer network system that can maintain a certain shape and has a series of unique properties. Polyvinyl alcohol hydrogel has been widely used in medical, biological and other industries due to its low toxicity and good biocompatibility. [0003] Studies have shown that nearly 70% of patients with general anesthesia can not close their eyelids completely, and if corresponding preventive corneal protection me...

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is that the polyvinyl alcohol hydrogel obtained by purely physical crosslinking is cloudy and opaque, which is inconvenient for clinical observation of the eyes of patients.