Novel degradable hemostatic material and preparing method thereof

A hemostatic material and a new technology, applied in the field of new degradable hemostatic materials and their preparation, can solve the problems of low oxidation degree, large particle size, high cost, etc., and achieve the effect of high oxidation degree, low cost and strong hemostatic ability

Inactive Publication Date: 2019-10-18
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oxidized regenerated cellulose hemostatic materials prepared by the existing technology all have the disadvan

Method used

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  • Novel degradable hemostatic material and preparing method thereof
  • Novel degradable hemostatic material and preparing method thereof

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preparation example Construction

[0039] The invention provides a hemostatic product meeting the clinical requirements of degradable hemostatic materials and a preparation method thereof. The specific plan is as follows:

[0040] 1. Pretreatment: add a certain amount of cellulose to one of the high-pressure homogenizer, refiner / defiberizer, low-temperature pulverizer, high-intensity ultrasonic machine, and dynamic high-pressure homogenizer, and perform repeated crushing operations until until the fiber length is significantly shortened. Filter the slurry to obtain a precipitate, wash the precipitate several times with deionized water, swell with a certain concentration of sodium hydroxide solution, filter and wash the swollen cellulose with ethanol of different solubility, and wash until Reserve after neutral.

[0041] 2. Oxidation:

[0042] (1) NO 2 oxidized regenerated cellulose

[0043] With CCl 4 As a solvent, prepare NO 2 Oxidation solution: add the prepared regenerated cellulose to the above oxida...

Embodiment 1

[0055] Example 1 Preparation of novel degradable hemostatic material

[0056] 1. Dissolve 100g of regenerated cellulose in 500ml of deionized water, add the suspension to a high-pressure homogenizer, repeat the homogenization 5 times, filter the slurry to obtain a precipitate, and wash the precipitate 5 times with deionized water After drying, the dried cellulose is swollen with 500ml of 5% sodium hydroxide for 1 hour, and the swollen cellulose is filtered and washed with 500ml of 80% ethanol, and washed until neutral for later use;

[0057] 2. With CCl 4 As a solvent, prepare 1000ml containing 10% NO 2 The oxidation solution; add regenerated cellulose to the above oxidation solution, the reaction temperature is 25°C, the reaction time is 20h, the oxidation process and the tank type ultrasonic process are carried out simultaneously, the ultrasonic frequency is 28kHz, and the power is 500W. After the reaction, the reactant Filter, first with 500ml CCl 4 Wash the oxide 3 time...

Embodiment 2

[0061] Example 2 Preparation of novel degradable hemostatic material

[0062] 1. Add 100 g of regenerated cellulose into a low-temperature pulverizer, and perform repeated pulverization treatment, and the pulverization times are 6 times. Swell the crushed and dried cellulose with 8% sodium hydroxide for 2 hours, filter and wash the swollen cellulose with 500ml of absolute ethanol, and set aside;

[0063] 2. Suspend the regenerated cellulose in 1000ml of deionized water, adjust the pH of the system to 10 with HCl and NaOH, set the temperature to 40°C, then add 1500ml of saturated sodium hypochlorite solution, react for 3 hours, the oxidation process is synchronized with the tank-type ultrasonic, ultrasonic Frequency 40kHz, power 1000W, after the reaction, wash with 50% ethanol and suction filter 3 times, then wash with distilled water until neutral, and finally wash with anhydrous ethanol 2 times, and suction filter to obtain the precipitate for later use;

[0064] 3. Add the ...

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Abstract

The invention provides a novel degradable hemostatic material and a preparing method thereof. The hemostatic material is oxidized regenerated cellulose loaded with a blood coagulation factor, whereinthe oxidized regenerated cellulose has the carboxyl content of 20-30%, the polymerization degree of 200-400 and the particle size of 90-120 micron, and the mass percentage of the blood coagulation factor in the oxidized regenerated cellulose l is 0.1-20%. The preparing method includes the steps of before-oxidation treatment, oxidation, blood coagulation factor complexing, electrostatic spraying, forming and the like. The novel degradable hemostatic material has the advantages of being continuous in process, high in efficiency and low in cost; the oxidized regenerated cellulose which is uniformand controllable in microsphere particle size, high in oxidation degree and strong in hemostatic capacity is prepared. The novel hemostatic material is suitable for massive haemorrhage and irregularpart and organ haemorrhage, high in degradability and rapid in hemostasis.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to a novel degradable hemostatic material and a preparation method thereof. Background technique [0002] As the most abundant natural polymer material in the world, cellulose has the characteristics of wide source of raw materials, renewability, biodegradability, and biocompatibility, and is considered to be an important resource for sustainable materials. However, with the advancement of science and technology and the improvement of the quality of human life, the characteristics of cellulose itself are far from meeting the needs of human beings. Oxidized regenerated cellulose is a gauze-like or cloth-like hemostatic material in which cellulose is oxidized into cellulose acid. It looks like cotton yarn, soft and thin in texture, and has good biocompatibility, degradability and safety. . Clinically, oxidized regenerated cellulose has been successfully used in neurosurg...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00A61L24/02C08B15/02
CPCA61L24/001A61L24/0015A61L24/0042A61L24/02A61L24/08A61L2300/418A61L2400/04C08B15/02C08L1/04
Inventor 朱翠兰石凌锋黄建国陶秀梅陈鹏
Owner NKD PHARMA CO LTD
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