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A moisture-permeable, hemostatic, antibacterial wound dressing and preparation method thereof

A wound dressing and moisture-permeable technology, applied in the medical field, can solve the problems of weak antibacterial effect, significant antibacterial ability, and biological cytotoxicity of ZnO particles, and achieve good moisture permeability, good antibacterial ability, and simple preparation process.

Active Publication Date: 2022-04-29
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The problem of wound infection caused by microorganisms has always been a threat to human health. Wound infections caused by bacteria and other pathogens often lead to problems such as suppuration and inflammation. If the bacterial infection in the wound is not treated in a timely and effective manner, it may even cause the body to die.
[0004] ZnO particles and quaternary ammonium salt antibacterial agents have been widely used clinically, but there are still some problems, such as ZnO particles have weak antibacterial effect, and quaternary ammonium salt antibacterial agents have significant antibacterial ability but have a certain effect on biological cells. toxicity

Method used

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  • A moisture-permeable, hemostatic, antibacterial wound dressing and preparation method thereof
  • A moisture-permeable, hemostatic, antibacterial wound dressing and preparation method thereof
  • A moisture-permeable, hemostatic, antibacterial wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] QAS 18 Preparation: Weigh 20mmol of N,N-dimethylethanolamine (DMEA), 24mmol of isocyanate propyltriethoxysilane (IPTS) and 1% dibutyltin dilaurate (DBEU) of DMEA molar weight in Put into a three-necked flask at room temperature, the solvent is DMF, and react at 90° C. for 24 h under a nitrogen atmosphere. After 24 hours, 20 mmol of 1-bromooctadecane and 1% potassium iodide (KI) in a molar amount of DMEA were added to the system and the temperature was raised to 120° C. to continue the reaction for 24 hours, maintaining a nitrogen atmosphere. After the reaction, the mixture was filtered through a Buchner funnel, and the filtrate was rotary evaporated to obtain a crude product. Purified with ethyl acetate and dried to obtain the quaternary ammonium salt product QAS 18 .

[0056] QAS 18 The chemical reaction equation and its structural formula are shown in figure 1 .

[0057] ZnO-QAS 18 Preparation of particles: Weigh 1g of ZnO powder and ultrasonically disperse it ...

Embodiment 2

[0060] (1) Weigh 1.5g of PCL solid and add it to 8.5g of formic acid, ultrasonically dissolve it for 1h and stir at room temperature for 6h to obtain 15wt% PCL spinning solution. Electrospinning process parameters: voltage 20kV, injection rate 0.5mL / h, room temperature, The relative humidity is 40-50%, the spinning distance is 15cm, and the drum speed is 100rpm / min. After spinning, put it into a vacuum oven at 45°C for 24 hours to obtain a pure PCL nanofiber mat, which is marked as PCL.

[0061] (2) Weigh 2g of zein powder and ultrasonically dissolve it in 38g of 75wt% ethanol / water solution, configure it into a 5wt% zein solution, use a spray bottle to spray the dissolved zein solution evenly on the surface of the PCL fiber membrane, and set the outlet pressure of the nitrogen cylinder to It is 0.2Mpa, the duration is 30s, and the drying time is 12h. The dressing is marked as PCL / zein.

[0062] (3) Weigh 50mg of ZnO and ultrasonically disperse it in 10mL of ethanol, use a sp...

Embodiment 3

[0064] Step (1) and (2) are with embodiment 2;

[0065] (3) Weigh 50 mg of ZnO-QAS prepared in Example 1 18 Ultrasonic disperse in 10mL ethanol, use a spray bottle to spray evenly on the surface of PCL / zein in step (2), the nitrogen outlet pressure is 0.2MPa, the duration is 30s, and it is dried for 12h. The dressing is marked as PCL / zein / ZnO-QAS 18 .

[0066] The sample that embodiment 2 and 3 prepares is carried out performance test, and result is as follows:

[0067] Samples PCL, PCL / zein, PCL / zein / ZnO prepared in Example 2 and PCL / zein / ZnO-QAS prepared in Example 3 18 The water vapor transmission rate of the dressing is Figure 5 As shown, the corresponding water vapor transmission rate is 3683±28mL / m 2 / day,3589±52mL / m 2 / day,3561±42mL / m 2 / day,3533±93mL / m 2 / day. It can be seen that after zein and ZnO-QAS 18 The coated fiber mat still has good moisture permeability. Usually the water vapor transmission rate of normal skin is 204mL / m 2 / day, the water vapor tra...

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Abstract

The invention discloses a moisture-permeable, hemostatic and antibacterial wound dressing and a preparation method thereof, belonging to the field of medical technology. The present invention first synthesized novel quaternary ammonium antibacterial agent QAS 18 , and then graft the quaternary ammonium antibacterial agent onto the surface of ZnO nanoparticles to prepare ZnO‑QAS 18 particles, followed by electrospinning and spray coating of zein protein and ZnO‑QAS 18 The wound dressing was prepared in the form of granules. The wound dressing of the invention has good moisture permeability, certain hemostatic ability, remarkable antibacterial effect, good biocompatibility, convenient preparation process and no pollution.

Description

technical field [0001] The invention relates to a moisture-permeable, hemostatic and antibacterial wound dressing and a preparation method thereof, belonging to the field of medical technology. Background technique [0002] The problem of wound infection caused by microorganisms has always been a threat to human health. Wound infections caused by pathogens such as bacteria often lead to problems such as suppuration and inflammation. If the bacterial infection in the wound is not treated in a timely and effective manner, it may even cause the body to die. In a natural environment, damaged skin is easily invaded by microorganisms such as bacteria, so timely treatment of wounds can largely avoid infection. [0003] Zein is the main storage protein in corn with abundant reserves and wide sources. As a natural plant protein, zein has good biocompatibility and degradability. Zein molecular chains are rich in sulfur-containing amino acids and hydrophobic amino acids, so disulfide ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/20A61L15/18A61L15/46A61L15/26D06M13/513D06M11/44D06M101/32
CPCA61L15/425A61L15/42A61L15/20A61L15/18A61L15/46A61L15/26D06M13/513D06M11/44D06M16/00A61L2400/04A61L2300/208A61L2300/404A61L2400/12A61L2300/102A61L2300/418D06M2101/32C08L67/04
Inventor 任学宏汪杨刘颖
Owner JIANGNAN UNIV
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