Controlled release performance test system of solid lipid nanospheres

Abstract

The invention provides a controlled release performance test system of solid lipid nanospheres. An image collector, an image processing module, a conductivity sensor, a signal processing circuit, a central processing unit, a display deice, a wireless transmission device and a monitoring platform monitors the release performance of the solid lipid nanospheres efficiently in real time, during test,a sodium chloride solution is wrapped in lipoid nucleus at preset temperature to prepare solid colloidal particles, the solid colloidal particles are placed and dissolved in a phosphate solution, thesolid colloidal particles release the sodium chloride solution in the dissolving process, the conductivity sensor detects a conductivity signal of the phosphate solution in the dissolving process of the solid colloidal particles, the central processing unit converts the received conductivity signal into a conductivity value, drafts a conductivity-time spectrum, and transmits the spectrum to a display device for display, and the wireless transmission device transmits the conductivity-time spectrum to the monitoring platform.

Description

technical field [0001] The invention relates to the field of performance testing of intelligent medicines, in particular to a performance testing system for controlled release of solid lipid nanoparticles. Background technique [0002] Solid lipid nanoparticles (SLN) are a new type of drug carrier, which has the advantages of targeted drug delivery, long-term stability, good physiological compatibility and sustained drug release. It can be absorbed through various methods such as oral administration, skin administration, and pulmonary administration. [0003] With the continuous development of medicine, traditional drug delivery methods can no longer meet the various needs of medical treatment, such as: prolonging the action time of drugs in vivo, improving bioavailability, reducing drug toxicity, etc. In the 1980s, after a series of drug carriers such as liposomes, microemulsions, and polymer nanoparticles were developed, people gradually turned their attention to the soli...

AI Technical Summary

Problems solved by technology

[0006] In the prior art, patent CN106860425A provides a kind of solid lipid nanoparticle of chloramphenicol, which involves the test of the release performance of the solid lipid nanoparticle, and it diffuses into the hydrochloric acid solution by the concentration of the solid lipid nanoparticle and Calculation of the release performance of solid lipid nanoparticles, however, the release of drugs cannot be monitored in real time, and the test accuracy is not high, so it cannot accurately represent the release performance of solid lipid nanoparticles

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