A test system for the controlled release performance of solid lipid nanoparticles

Abstract

The invention provides a test system for the controlled release performance of solid lipid nanoparticles, which utilizes an image acquisition device, an image processing module, a conductivity sensor, a signal processing circuit, a central processing device, a display device, a wireless transmission device and a monitoring platform to test solid lipid nanoparticles. The release performance of nanoparticles is monitored in real time and efficiently. During the test, at a preset temperature, the sodium chloride solution is wrapped in the lipid core to make solid colloidal particles, and the solid colloidal particles are placed in the phosphate solution. The colloidal particles are dissolved in the phosphate solution, and the solid colloidal particles release the sodium chloride solution during the dissolution process. The conductivity sensor is used to detect the conductivity signal of the phosphate solution during the dissolution process of the solid colloidal particles, and the central processing unit will receive the The conductivity signal is converted into a conductivity value, drawn as a conductivity-time spectrum and transmitted to the display device for display, and at the same time the conductivity-time spectrum is transmitted to the monitoring platform through a wireless transmission device.

Description

technical field [0001] The invention relates to the field of performance testing of intelligent medicines, in particular to a performance testing system for controlled release of solid lipid nanoparticles. Background technique [0002] Solid lipid nanoparticles (SLN) is a new type of drug carrier, which has the advantages of targeted drug delivery, long-term stability, good physiological compatibility and sustained drug release. It can be absorbed through various methods such as oral administration, skin administration, and pulmonary administration. [0003] With the continuous development of medicine, traditional drug delivery methods can no longer meet the various needs of medical treatment, such as: prolonging the action time of drugs in vivo, improving bioavailability, reducing drug toxicity, etc. In the 1980s, after a series of drug carriers such as liposomes, microemulsions, and polymer nanoparticles were developed, people gradually turned their attention to the solid...

AI Technical Summary

Problems solved by technology

[0006] In the prior art, patent CN106860425A provides a kind of solid lipid nanoparticle of chloramphenicol, which involves the test of the release performance of the solid lipid nanoparticle, and it diffuses into the hydrochloric acid solution by the concentration of the solid lipid nanoparticle and Calculation of the release performance of solid lipid nanoparticles, however, the release of drugs cannot be monitored in real time, and the test accuracy is not high, so it cannot accurately represent the release performance of solid lipid nanoparticles

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