Oral care composition for resisting dental acid erosion

A technology for oral care and dental acid erosion, applied in the field of oral care, can solve the problems of high cost, complicated production process, complex tooth sensitive components, etc., and achieve the effect of improving the demineralization again

Pending Publication Date: 2019-11-01
HAWLEY & HAZEL BVI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The toothpaste adds ginger root extract, Cimicifuga extract, Moutan cortex extract, and Magnolia officinalis extract to calm the pulp nerves, and adds strontium sa...

Method used

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  • Oral care composition for resisting dental acid erosion
  • Oral care composition for resisting dental acid erosion
  • Oral care composition for resisting dental acid erosion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1- Embodiment 5

[0075] A kind of toothpaste, formula according to the table, is prepared into toothpaste product by conventional method:

[0076]

[0077] The particle size of at least 50% of the HAP selected in Example 1 and Example 2 does not exceed 100 nanometers.

[0078] In the Magnolia Bark Extract selected in Embodiment 1, Embodiment 2 and Example 4, the weight and number ratio of the Honokiol and Magnolol is 5:5, and in the Magnolia Bark Extract selected in Example 3, The ratio of parts by weight of honokiol to magnolol is 1:9, and in the magnolol extract selected in Example 5, the ratio of parts by weight of honokiol to magnolol is 9:1. .

[0079] The detection method of oral care composition acid corrosion resistance of the present invention is as follows:

[0080] Simulate dental sample preparation steps

[0081] 1. Dentin Sample Preparation

[0082] Preparation of bovine tooth slices: Take bovine incisors, cut 2mm thick tooth root slices at a distance of 2mm from the juncti...

Embodiment 6-9

[0097]

[0098] At least 30% of the HAP selected in Examples 6-9 had a particle size not exceeding 100 nanometers.

[0099] In the Magnolia officinalis extract selected in Examples 6-9, the weight-number ratio of honokiol to magnolol is 5:5.

[0100] Study on the Retention Experiment of Magnolia Bark Extract in Dental Hard Tissue

[0101] 1) Collection has Stimulated whole saliva was centrifuged at 10,000 rpm for 20 minutes to obtain saliva supernatant.

[0102] 2) 1 piece of HAP disk / 1ml saliva supernatant was incubated overnight in a 10ml centrifuge tube in a shaking shaker at 37°C to form a pellicle.

[0103] 3) Prepare toothpaste slurries of formula 3 and formula 4 respectively: prepare toothpaste slurries with toothpaste and water at a ratio of 1:2wt (accurately weighed, accurate to 0.0001g), and stir and mix for more than 30 minutes to ensure uniform mixing.

[0104] 4) Aspirate the saliva supernatant in 2), add 1ml of toothpaste slurry into a centrifuge tube, sha...

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Abstract

The present invention discloses an oral care composition for resisting dental acid erosion. The oral care composition comprises hydroxyapatite and an officinal magnolia bark extract, wherein a weightratio of the hydroxyapatite is larger than or equal to 1.0%, and the officinal magnolia bark extract accounts for 0.1-1.0% of the total weight. The hydroxyapatite and officinal magnolia bark extract of the oral care composition have a synergistic effect and can form a remineralizing layer on surfaces of teeth, the newly formed remineralizing layer has capacity of resisting the acid erosion, so that the oral care composition can effectively solves problems of demineralization of the remineralizing layer or tooth tubule re-exposure and tooth re-sensitivity.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to an oral care composition for resisting tooth erosion. Background technique [0002] Teeth are mainly composed of calcium phosphate salts. Refluxed gastric acid, carbonated beverages or carbohydrates in food are fermented in the mouth to produce acid, etc., which will cause tooth minerals to dissolve and form dental caries or tooth tubules exposed to cause sensitivity. [0003] There are two effective ways to treat tooth sensitivity clinically: one is to calm the pulp nerve, reduce the sensitivity of dentin and pulp nerve endings, thereby alleviating the sore symptoms caused by dentin hypersensitivity; the other is to seal the dentin tubules, reduce the Dentin permeability, reducing or preventing fluid flow within the dentin. [0004] At present, most oral care products (such as toothpaste) on the market achieve anti-sensitivity effects by adding chemical substances such as str...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/24A61K8/34A61Q11/00
CPCA61K8/9789A61K8/24A61K8/347A61Q11/00
Inventor 黄美艳李艳晓岳红雷
Owner HAWLEY & HAZEL BVI
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