Composite nerve restoration catheter and preparation method thereof

A nerve repair and catheter technology, which is applied in the field of medical biomaterials and medical devices, can solve the problems of poor operability and cumbersome steps, and achieve the effects of improving mechanical strength, simple manufacturing process, and promoting nerve regeneration

Inactive Publication Date: 2019-11-08
TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, nerve conduits with good biocompatibility, directional guidance for nerve regeneration, degradability and good support for the conduit structure are still in the research and exploration stage. Many patented technologies have proposed various methods for preparing nerve conduits, and the steps are relatively Complicated and poor operability

Method used

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  • Composite nerve restoration catheter and preparation method thereof
  • Composite nerve restoration catheter and preparation method thereof
  • Composite nerve restoration catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Preparation of the inner layer collagen catheter of the composite nerve repair catheter

[0049] Taking the preparation of the inner layer collagen catheter with 6% collagen slurry as an example, the preparation steps of the inner layer catheter are as follows:

[0050] (1) Mix according to the ratio of 0.6g ground and pulverized type I collagen: 10ml (0.6M acetic acid solution), acidify for 200min to obtain a uniform collagen slurry with a concentration of 6% (mass volume ratio);

[0051] (2) Centrifuge the collagen slurry in step (1): the temperature is controlled at 10±2°C, the rotation speed is 4000rpm, and the time is 60min;

[0052] (3) Centrifuge and install to the mould: take a hollow stainless steel cylindrical mold with a diameter of 6 mm and a length of 30 mm, inject the collagen slurry, and insert the mould, with a central axis diameter of 4 mm;

[0053] (4) Freeze-drying: gradient freezing: the mold is placed in the elevator, the descending spee...

Embodiment 2

[0058] Example 2: Preparation Method 1 of the Outer Layer of the Composite Nerve Repair Catheter

[0059] (1) Electrospinning process: 0.95g polylactic acid and 0.05g chitosan are dissolved in trifluoroacetic acid, form the spinning solution that uniform chitosan mass content is 5%, polylactic acid: chitosan=9.5 : 0.5 (mass ratio); the collagen catheter prepared by embodiment 1 is placed in an electrostatic field, electrostatic high voltage 20kV, receiving distance 20cm, advancing speed 1.8ml / h, spinning time 90min;

[0060] (2) Vacuum drying at 40°C for 24 hours;

[0061] (3) Ethylene oxide gas sterilization after primary packaging.

Embodiment 3

[0062] Example 3: Preparation Method 2 of the Outer Layer of the Composite Nerve Repair Catheter

[0063] (1) Electrospinning process: 0.9g polylactic acid and 0.1g chitosan are dissolved in trifluoroacetic acid, form the spinning solution of uniform chitosan quality 10%, polylactic acid: chitosan=9:1 (mass ratio); the collagen catheter prepared in Example 1 is placed in an electrostatic field, the electrostatic high voltage is 20kV, the receiving distance is 20cm, the advancing speed is 1.8ml / h, and the spinning time is 90min;

[0064] (2) Vacuum drying at 40°C for 24 hours;

[0065] (3) Ethylene oxide gas sterilization after primary packaging.

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Abstract

The invention provides a composite nerve restoration catheter and a preparation method thereof. The composite nerve restoration catheter comprises a hollow natural polymer catheter and an electrostatic spinning fiber layer coating the natural polymer catheter, wherein the natural polymer catheter is made of collagen slurry with the mass/volume concentration of 4%-7%, the electrostatic spinning fiber layer is made of a spinning solution containing polylactic acid and chitosan, and the mass ratio of the polylactic acid to the chitosan is (6-9.5):(0.5-4). The mechanical strength of the collagen catheter is obviously improved while the characteristics of the collagen catheter are kept, the good 3D structure is maintained in the nerve restoration process, and the catheter collapse is avoided. The production process is simple and prone to industrialization, and materials are widely sourced and cheap.

Description

technical field [0001] The invention belongs to the field of medical biological materials and medical equipment, and in particular relates to a composite nerve repair catheter and its preparation method and application. Background technique [0002] Nerve conduit is a hollow tubular structure that uses the principles and methods of tissue engineering to prepare natural and / or synthetic degradable polymer materials that can establish nerve bridges at the damaged ends of peripheral nerves, and can provide suitable nerve regeneration for damaged nerves. Microenvironment. Commonly used natural materials include collagen, gelatin, chitosan, silk fibroin, etc., all of which have good biocompatibility and low immunogenicity; synthetic degradable polymer materials include polylactic acid, polyhydroxybutyrate valeric acid copolymer Ester, poly(D,L-lactic acid-co-glycolic acid), etc., have good mechanical strength and degradability characteristics. [0003] The process of nerve repa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/24A61L27/48D01F8/14D01F8/18C08J9/28C08L89/00D01D5/00
CPCA61L27/24A61L27/48A61L27/50A61L27/56D01F8/14D01F8/18C08J9/28D01D5/0038A61L2430/32C08J2389/00C08J2201/0482
Inventor 陈刚杨洪阳董会李晓静李满意孙冰冰
Owner TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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