Treatment for gingivitis

A technology for gingivitis, inflammation of the gums, applied in the field of treatment of gingivitis, addressing issues such as the oral microbiome in general and adverse oral health outcomes

Pending Publication Date: 2019-11-19
UNIVERSITY OF MELBOURNE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, perturbation of the oral microbiome through modern lifestyles (e.g. dietary sugar, smoking, poor oral hygiene, etc.) or other factors (e.g. genetic predisposition) can have adverse consequences on general and oral health

Method used

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  • Treatment for gingivitis
  • Treatment for gingivitis
  • Treatment for gingivitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0212] Clinical Study: Prebiotic Effect of CPP-ACP on Supragingival Plaque and Oral Health

[0213] Research purposes

[0214] main purpose

[0215] Comparison of the effects of chewing sugar-free gum containing 56.4 mg CPP-ACP, chewing sugar-free gum containing 18.8 mg CPP-ACP, and no chewing gum on the microbial composition of supragingival plaque formed on maxillary molars, each combined with experience 14 days of normal oral hygiene routine.

[0216] secondary purpose

[0217] A. Compare the effects of chewing sugar-free gum containing 56.4 mg CPP-ACP, chewing sugar-free gum containing 18.8 mg CPP-ACP, and no chewing gum on the development of supragingival plaque, all combined with normal oral cavity after 14 days hygiene procedures.

[0218] B. Comparison of the effect on the development of gingivitis of chewing sugar-free gum containing 56.4 mg CPP-ACP, chewing sugar-free gum containing 18.8 mg CPP-ACP, and no chewing gum, each in combination with a normal oral hygie...

Embodiment 2

[0320] SnF 2 Promoting CPP-ACP probiotic formation in polymicrobial models

[0321] Multi-species oral biofilm culture

[0322] Six representative oral bacterial species of simulated supragingival plaque, Streptococcus sanguis (NCTC 7863), Streptococcus mutans Ingbritt, Actinomyces naesei (NCTC 10301), Veillonella parvum (ATCC 17745), Lactobacillus casei (NCDO 161) and Fusobacterium nucleatum (ATCC 10953) (Table 5) were cultured as polymicrobial biofilms on human tooth enamel substrates in constant depth film fermenters (CDFF; Cardiff University, UK). Place the CDFF in a 37°C incubator under anaerobic conditions by adding 5% CO to 1L / h 2 N 2 A constant flow is maintained. The CDFF consists of 15 removable polytetrafluoroethylene (PTFE) disks on a circular platform rotating at a constant speed of 3 rpm. Use artificial saliva medium (ASM, 2.5g / L mucin type II (pig, stomach, Sigma), 2.0g / L bacto-peptone (Oxoid), 2.0g / L tryptone (Oxoid), 1.0g / L yeast extract substance (Oxoid...

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Abstract

The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and / or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and / or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteriaat an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.

Description

[0001] Cross References to Related Applications [0002] This application claims priority from Australian Provisional Application No. 2017900893, the entire content of which is incorporated herein by reference in its entirety. [0003] field of invention [0004] The present invention relates to compositions and their use in oral care. In particular, the compositions and methods are useful for maintaining oral health and / or treating various oral conditions such as gingivitis. [0005] Background of the invention [0006] Oral microbes have co-evolved and coexisted with their hosts for millions of years in a largely harmonious symbiotic relationship. The host and the oral microbiome do not exist as distinct, but together form a "superorganism" or holobiont, where the oral microbiome plays an important role in the maintenance and health of the oral cavity. The oral cavity provides the environment for the second most diverse microbial community in the body, with more than 700 r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/033A61K6/838
CPCA61K6/20A61K6/838A61P1/02A61P31/04A61Q11/00A61K8/24A61K33/42A61K33/16A61K8/21A61K9/0058A61K38/1709
Inventor 埃里克·查尔斯·雷诺兹
Owner UNIVERSITY OF MELBOURNE
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