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Composition for treatment and/or prevention of alzheimer's disease

A technology for Alzheimer's disease, composition, applied in the direction of drug combination, food science, plant raw materials, etc., can solve problems such as harmful side effects, reporting, etc., to achieve effective treatment and/or prevention effects

Pending Publication Date: 2019-11-22
GLOVIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] For α-GPC, in addition to the cognitive function improvement effect, useful effects such as growth hormone secretion promotion, liver dysfunction improvement, blood pressure reduction, and choline concentration reduction improvement have been confirmed, but harmful side effects have also been reported

Method used

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  • Composition for treatment and/or prevention of alzheimer's disease
  • Composition for treatment and/or prevention of alzheimer's disease
  • Composition for treatment and/or prevention of alzheimer's disease

Examples

Experimental program
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Embodiment

[0064] The invention is illustrated using the following examples, but the invention is not limited to the following examples.

[0065] (A) Animals, breeding environment

[0066] The human-introduced Swedish shift-type APP (APPK) used in the following experiments 670N / M671L ) gene genetically modified mouse Tg2576 was obtained from The Jackson Laboratory in the United States. In this mouse, it is known that Aβ accumulates in large quantities in the brain after 9 months of age due to overexpression of APP, and furthermore, age-dependent demyelination occurs after 24 months of age. The obtained Tg2576 mice were reared in an environment with a 12-hour / 12-hour light cycle (turn on the light at 7:00 and turn off the light at 19:00) using a breeding facility with a room temperature of 25±1°C and a relative humidity of 55±1%. . In addition, this animal experiment was carried out using the animal experiment facility in the said university in compliance with the Keio University Anima...

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PUM

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Abstract

Provided is a composition for the treatment and / or prevention of Alzheimer's disease having an improved therapeutic or prophylactic effect together with reduced side effects. This composition for thetreatment and / or prevention of Alzheimer's disease contains at least one compound selected from the group consisting of glycerophosphocholine (G) and pharmaceutically acceptable salts thereof as a first active ingredient and at least one compound selected from the group consisting of herperidin (H), narirutin (N), and pharmaceutically acceptable salts thereof as a second active ingredient. This composition promotes remyelination, promotes the activity of alpha-secretase, and also suppresses the expression of beta-secretase.

Description

technical field [0001] The present invention relates to compositions for the treatment and / or prevention of Alzheimer's disease. Background technique [0002] In today's super-aging society, the number of dementia patients visiting medical institutions is increasing rapidly. According to the 2015 World Alzheimer Report, there were 46.8 million people living in the world in 2015. The number of dementia patients is expected to increase to 131.5 million by 2050. This value has approximately doubled every 20 years, warning that dementia is a disease that poses a crisis on a global scale. Therefore, it is urgent to establish effective treatment and prevention methods for dementia. [0003] Alzheimer's disease is the most common cause of dementia. Although progressive dementia is the main condition, many senile plaques and neurofibrillary changes have been confirmed in the brain as pathological features. Therefore, it is considered that the cause of Alzheimer's disease is the d...

Claims

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Application Information

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IPC IPC(8): A61K31/685A23L33/10A23L33/105A61K31/7048A61K36/752A61P25/00A61P25/28A61P43/00
CPCA23L33/10A23L33/105A61K31/685A61K31/7048A61K36/752A61P25/00A61P25/28A61P43/00A61K2300/00A23V2002/00
Inventor 阿相皓晃村濑仁章
Owner GLOVIA
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