Biological composite air-permeable dressing and preparation method thereof

A biological and natural polymer technology, applied in the field of biocomposite breathable dressings and its preparation, can solve the problems of unable to keep the wound wet, unable to absorb tissue fluid, and affect wound healing, achieve stable drug loading and drug release, and eliminate pain Stimulation and secondary trauma and secondary infection, good bioremediation effect

Inactive Publication Date: 2019-11-29
赵勤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Aiming at the technical problems in the prior art that the wound surface cannot be kept moist, and it is easy to cause secondary injury to the wound, and cannot absorb the tissue fluid secreted by the wound, which affects wound healing, the present invention provides a biocomposite breathable dressing and a preparation method thereof. The biocomposite breathable dressing can block the invasion of external bacteria to the wound tissue, form an antibacterial isolation protection for the wound, create a moist and repairing nutritional environment for the wound, prevent scabbing and adhesion of the wound, and reduce the pain caused by dressing change and remova...

Method used

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  • Biological composite air-permeable dressing and preparation method thereof
  • Biological composite air-permeable dressing and preparation method thereof
  • Biological composite air-permeable dressing and preparation method thereof

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preparation example Construction

[0057] The present invention also provides a preparation method of a biocomposite breathable dressing, the method comprising the following steps: step 1: mixing and stirring the natural polymer polysaccharide and a humectant until uniformly dispersed; step 2: mixing the cross-linking agent, the acid-base regulator , anti-oxidant, and drug-loaded functional ingredients are dissolved in water and added to the evenly dispersed mixture of natural high-molecular polysaccharides and humectants, and the natural high-molecular polysaccharides are fully stirred; step 3: prepare in step 2 Heat the preparation to any temperature between 75°C and 85°C to fully dissolve, then keep the dissolution temperature at a constant temperature for 30 minutes, and let it stand for natural cooling until the temperature drops to 50°C and store at a constant temperature; step 4: store at a constant temperature of 50°C in step 3 The formulation is coated or cast into a film, dehydrated and dried into a dr...

Embodiment 1

[0070]

[0071] Step 1: Mix carrageenan, guar gum and glycerin and stir until evenly dispersed;

[0072] Step 2: Dissolve calcium chloride, sodium chloride, citric acid, polylysine, phenoxyethanol, and silk fibroin in water and add them to the evenly dispersed mixture of carrageenan, guar gum, and glycerin. And make the carrageenan and guar gum fully stirred;

[0073] Step 3: Heat the preparation prepared in step 2 to 75°C and fully dissolve it, then keep the dissolution temperature at a constant temperature for 30 minutes, let it stand for natural cooling, and store it at a constant temperature when the temperature drops to 50°C;

[0074] Step 4: Coat or cast the formulation stored at a constant temperature of 50°C in step 3 to form a film, and use microwave or infrared dehydration drying equipment to dehydrate and dry at 40°C to form a dry film, then cover with a protective film, wind into a film, and cut into shape , Packaging and sealing.

Embodiment 2

[0076]

[0077]

[0078] Step 1: Mix locust bean gum, sodium alginate and glycerin and stir until uniformly dispersed;

[0079] Step 2: Dissolve calcium chloride, citric acid, phenoxyethanol, polylysine, and silk fibroin in water and add them to the evenly dispersed mixture of locust bean gum, sodium alginate and glycerin, and make the locust Soybean gum and sodium alginate are fully stirred;

[0080] Step 3: Heat the preparation prepared in step 2 to 80°C and fully dissolve it, then keep the dissolution temperature at a constant temperature for 30 minutes, and let it stand for natural cooling until the temperature drops to 50°C and store at a constant temperature;

[0081] Step 4: Coat or cast the preparation stored at a constant temperature of 50°C in step 3 to form a film, and use microwave or infrared dehydration drying equipment to dehydrate and dry at 50°C to form a dry film, then cover with a protective film, roll into a film, cut into shape, The package is seale...

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Abstract

The invention provides a biological composite air-permeable dressing and a preparation method thereof. The biological composite air-permeable dressing consists of the following components in percentage by weight: 0.1-2% of natural macromolecule polysaccharides, 5-15% of a moisturizing agent, 0.012-0.15% of a cross-linking agent, 0.01-0.2% of an antioxidant, 0.01-1% of an acid-base adjusting agent,0.01-20% of a medicine carrying effective component and the balance of water, wherein the pH value of the dressing is within 6.5-7.2. By adopting the biological composite air-permeable dressing provided by the invention, antibacterial isolation protection can be formed for a wound surface, a wet repairing nutrition environment can be created for the wound surface, pain irritation and secondary traumas caused by medicine change peeling can be reduced, functions of cold compress and trauma cooling can be achieved, skin has normal physiological metabolism, hydrops oozing out from the wound surface can be cleaned and absorbed, stable drug carrying and release can be achieved, the trauma healing speed can be increased, the treatment time can be shortened, meanwhile, the dressing has no exclusiveness and is high in biocompatibility and free of anaphylaxis, and the dressing is a transparent membrane material, so that a medical operator can visibly and accurately observe the wound surface healing situation of a patient.

Description

technical field [0001] The invention relates to the field of clinical medical treatment and restoration treatment, in particular to a biocomposite breathable dressing and a preparation method thereof. Background technique [0002] The skin is the first barrier between the body and the natural world. It can prevent the invasion of pathogenic microorganisms in the environment and the loss of body fluids. It is a very important organ of the body. However, skin trauma is also very common in life, especially skin damage caused by burns, radiation burns or other reasons, especially large-area skin damage, which will lead to failure of human internal organs, causing life-threatening, mild Patients also suffer from poor quality of life sequelae due to damaged or missing skin. [0003] Dressings should not only protect the wound, prevent wound infection, but also repair the wound. If there is no external dressing that can approach or partially replace the comprehensive barrier of sk...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/20A61L15/18A61L15/26A61L15/32A61L15/44A61L15/46A61L15/42A61L15/62
CPCA61L15/18A61L15/20A61L15/26A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46A61L15/62A61L2300/404A61L2300/412A61L2300/602C08L5/00C08L5/04C08L77/04C08L89/00
Inventor 吴婕周琪佳赵勤袁玉先王大儒
Owner 赵勤
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