Biological composite air-permeable dressing and preparation method thereof

A biological and natural polymer technology, applied in the field of biocomposite breathable dressings and its preparation, can solve the problems of unable to keep the wound wet, unable to absorb tissue fluid, and affect wound healing, achieve stable drug loading and drug release, and eliminate pain Stimulation and secondary trauma and secondary infection, good bioremediation effect

A biological and natural polymer technology, applied in the field of biocomposite breathable dressings and its preparation, can solve the problems of unable to keep the wound wet, unable to absorb tissue fluid, and affect wound healing, achieve stable drug loading and drug release, and eliminate pain Stimulation and secondary trauma and secondary infection, good bioremediation effect

CN110507845AInactive Publication Date: 2019-11-29赵勤
7 Cites 7 Cited by

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biological composite air-permeable dressing and preparation method thereof
  • Biological composite air-permeable dressing and preparation method thereof
  • Biological composite air-permeable dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] The present invention also provides a preparation method of a biocomposite breathable dressing, the method comprising the following steps: step 1: mixing and stirring the natural polymer polysaccharide and a humectant until uniformly dispersed; step 2: mixing the cross-linking agent, the acid-base regulator , anti-oxidant, and drug-loaded functional ingredients are dissolved in water and added to the evenly dispersed mixture of natural high-molecular polysaccharides and humectants, and the natural high-molecular polysaccharides are fully stirred; step 3: prepare in step 2 Heat the preparation to any temperature between 75°C and 85°C to fully dissolve, then keep the dissolution temperature at a constant temperature for 30 minutes, and let it stand for natural cooling until the temperature drops to 50°C and store at a constant temperature; step 4: store at a constant temperature of 50°C in step 3 The formulation is coated or cast into a film, dehydrated and dried into a dr...

Embodiment 1

[0070]

[0071] Step 1: Mix carrageenan, guar gum and glycerin and stir until evenly dispersed;

[0072] Step 2: Dissolve calcium chloride, sodium chloride, citric acid, polylysine, phenoxyethanol, and silk fibroin in water and add them to the evenly dispersed mixture of carrageenan, guar gum, and glycerin. And make the carrageenan and guar gum fully stirred;

[0073] Step 3: Heat the preparation prepared in step 2 to 75°C and fully dissolve it, then keep the dissolution temperature at a constant temperature for 30 minutes, let it stand for natural cooling, and store it at a constant temperature when the temperature drops to 50°C;

[0074] Step 4: Coat or cast the formulation stored at a constant temperature of 50°C in step 3 to form a film, and use microwave or infrared dehydration drying equipment to dehydrate and dry at 40°C to form a dry film, then cover with a protective film, wind into a film, and cut into shape , Packaging and sealing.

Embodiment 2

[0076]

[0077]

[0078] Step 1: Mix locust bean gum, sodium alginate and glycerin and stir until uniformly dispersed;

[0079] Step 2: Dissolve calcium chloride, citric acid, phenoxyethanol, polylysine, and silk fibroin in water and add them to the evenly dispersed mixture of locust bean gum, sodium alginate and glycerin, and make the locust Soybean gum and sodium alginate are fully stirred;

[0080] Step 3: Heat the preparation prepared in step 2 to 80°C and fully dissolve it, then keep the dissolution temperature at a constant temperature for 30 minutes, and let it stand for natural cooling until the temperature drops to 50°C and store at a constant temperature;

[0081] Step 4: Coat or cast the preparation stored at a constant temperature of 50°C in step 3 to form a film, and use microwave or infrared dehydration drying equipment to dehydrate and dry at 50°C to form a dry film, then cover with a protective film, roll into a film, cut into shape, The package is seale...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a biological composite air-permeable dressing and a preparation method thereof. The biological composite air-permeable dressing consists of the following components in percentage by weight: 0.1-2% of natural macromolecule polysaccharides, 5-15% of a moisturizing agent, 0.012-0.15% of a cross-linking agent, 0.01-0.2% of an antioxidant, 0.01-1% of an acid-base adjusting agent,0.01-20% of a medicine carrying effective component and the balance of water, wherein the pH value of the dressing is within 6.5-7.2. By adopting the biological composite air-permeable dressing provided by the invention, antibacterial isolation protection can be formed for a wound surface, a wet repairing nutrition environment can be created for the wound surface, pain irritation and secondary traumas caused by medicine change peeling can be reduced, functions of cold compress and trauma cooling can be achieved, skin has normal physiological metabolism, hydrops oozing out from the wound surface can be cleaned and absorbed, stable drug carrying and release can be achieved, the trauma healing speed can be increased, the treatment time can be shortened, meanwhile, the dressing has no exclusiveness and is high in biocompatibility and free of anaphylaxis, and the dressing is a transparent membrane material, so that a medical operator can visibly and accurately observe the wound surface healing situation of a patient.

Description

technical field [0001] The invention relates to the field of clinical medical treatment and restoration treatment, in particular to a biocomposite breathable dressing and a preparation method thereof. Background technique [0002] The skin is the first barrier between the body and the natural world. It can prevent the invasion of pathogenic microorganisms in the environment and the loss of body fluids. It is a very important organ of the body. However, skin trauma is also very common in life, especially skin damage caused by burns, radiation burns or other reasons, especially large-area skin damage, which will lead to failure of human internal organs, causing life-threatening, mild Patients also suffer from poor quality of life sequelae due to damaged or missing skin. [0003] Dressings should not only protect the wound, prevent wound infection, but also repair the wound. If there is no external dressing that can approach or partially replace the comprehensive barrier of sk...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
29 Nov 2019
Publication
CN110507845A
IPC
A61L15/28; A61L15/20; A61L15/18; A61L15/26; A61L15/32; A61L15/44; A61L15/46; A61L15/42; A61L15/62
CPC
A61L15/18; A61L15/20; A61L15/26; A61L15/28; A61L15/32; A61L15/42; A61L15/44; A61L15/46
Inventors
吴婕; 周琪佳