Glucocorticoid receptor modulators to treat cervical cancer

Abstract

Methods for treating a subject having a cancerous tumor are disclosed. The methods comprise administering to the subject an effective amount of a non-steroidal selective glucocorticoid receptor modulator (SGRM) and an effective amount of a chemotherapeutic agent. The tumor may be cervical cancer. The SGRM may be a fused azadecalin. In embodiments, the SGRM may be a heteroaryl ketone fused azadecalin or an octahydro fused azadecalin.

Description

Background technique [0001] Cancer is the leading cause of death in the United States. For example, cervical cancer often has a poor prognosis even when diagnosed early, and signs and symptoms may not appear until the cancer is very advanced and complete surgical removal becomes impossible. [0002] Conventional treatment options for cancers such as cervical cancer include surgery, radiation therapy, and chemotherapy. Not all cancers, and not all cervical cancers, are resectable when diagnosed. Tumors such as cervical cancer tumors that are at an advanced stage usually require radiation therapy or chemotherapy for treatment. [0003] Radiation therapy requires maximum exposure of the affected tissue while sparing normal surrounding tissue. Interstitial therapy, in which needles containing radioactive sources are embedded in tumors, has emerged as a valuable new approach. In this way, large doses of radiation can be delivered locally without harming surrounding normal struc...

AI Technical Summary

Problems solved by technology

Consequently, reports in the literature are often contradictory, and it remains unclear whether glucocorticoid signaling has an effect on cancer, and whether this effect may be a positive or negative one

[0006] Therefore, there is a need for improved treatments for cancerous tumors, including cervical cancer, given the lack of good treatment options for many cancer patients

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