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Separation and extraction method of croton essential oil, and application

An extraction method, the technology of croton essence, is applied in the directions of essential oils/spices, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the cumbersome and complicated preparation method of croton essential oil, and the safety of medication cannot be guaranteed , poor controllability and other issues, to achieve good clinical application potential, good therapeutic effect, and easy operation

Inactive Publication Date: 2019-12-06
SHANDONG INST OF POMOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The crotonin (a toxic protein) contained in croton oil is a toxic component, which can be denatured and inactivated by heating and "cooking" to reduce toxicity, but high cooking temperature will destroy the content of crotonin in croton, However, the traditional preparation method of croton essential oil is cumbersome and complicated for modern applications, and the controllability is poor, and the safety of medication cannot be guaranteed.

Method used

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  • Separation and extraction method of croton essential oil, and application
  • Separation and extraction method of croton essential oil, and application
  • Separation and extraction method of croton essential oil, and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A method for separating and extracting croton essential oil, adopting the following steps:

[0040] (1) Get the croton fruit, peel off the husk to obtain the croton seed kernel, grind the croton kernel to a size of 20 meshes, add the Leucaena junica extract to the croton kernel powder and freeze-dry it, and place it at a humidity of 20% and a temperature of 40°C The reaction occurred for 2 hours, and then the treated croton kernel powder was processed under a pressure of 150Mpa for 8 minutes; wherein, the preparation method of the Leucaena extract was as follows: uniformly mix the Leucaena and water, extract at 80°C for 1-2 hours, concentrate, Add ethanol to adjust the ethanol degree to 75-80, let it stand overnight, centrifuge, freeze-dry the precipitate, add water to obtain the extract of Leucaena juncea; the mass ratio of Leucaena and water is 1:20; the dried precipitate and water The mass ratio is 1:5; the mass ratio of the croton kernel powder and Leucaena extract ...

Embodiment 2

[0044] A method for separating and extracting croton essential oil, adopting the following steps:

[0045] (1) Get the croton fruit, peel off the husk to obtain the croton seed kernel, grind the croton kernel to a particle size of 50 mesh, add the Leucaena juniperus extract to the croton kernel powder and freeze-dry it, and dry it at a humidity of 25% and a temperature of 50 The reaction occurred at ℃ for 3 hours; then the processed croton kernel powder was processed under the pressure of 180Mpa for 5min; the preparation method of the Leucaena extract was as follows: mix the Leucaena and water evenly, extract at 90°C for 2 hours, concentrate, add ethanol to adjust The ethanol degree is 80, stand overnight, centrifuge, freeze-dry the precipitate, and add water to obtain the extract of Leucaena juniperus; the mass ratio of Leucaena juniperus to water is 1:20; the mass ratio of dried precipitate to water is 1 :5.

[0046] (2) Add the croton kernel powder after step (1) processin...

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Abstract

The invention relates to the field of the biochemical industry and biological extraction, and more specifically relates to a separation and extraction method of croton essential oil, and an application. The method comprises the following steps: crushing croton kernels and treating the same; adding the treated croton kernel powder into a supercritical extraction container, inputting supercritical carbon dioxide fluid in the extraction container, and extracting the same; enabling the extracted carbon dioxide fluid to enter a separator to separate, wherein the flow of the carbon dioxide is 2L / min, and the material discharged from the separator is the croton essential oil. The effective ingredients of the croton essential oil can be reserved as much as possible, the croton medicinal material resources can be sufficiently utilized, the crotin is inactivated, and the toxicity is reduced.

Description

technical field [0001] The invention relates to the fields of biochemical engineering and biological extraction, and more specifically relates to a method for separating and extracting croton essential oil and its application. Background technique [0002] The genus Croton belongs to the Euphorbiaceae family and belongs to about 1,300 species widely distributed in tropical and subtropical regions. Croton tiglium L. is one of the genus Croton, and its seeds are called "Badou" in mainland China. The chemical composition of plants proves all the uses and treatments for different diseases. Previous studies investigating the chemical composition of C. tiglium fruits identified different types of diterpenes, and in particular a number of bioactive phorbol esters were isolated and evaluated from this species (Bauer et al., 1983; Colburn et al., 1982; Hecker, 1981; Marshall) et al. , 1985). Previous reports have shown that croton essential oil has laxative, analgesic, antibacter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B9/02A61K36/47A61K47/46A61P35/00A61K131/00
CPCC11B9/025C11B9/022A61K36/47A61K47/46A61P35/00
Inventor 牛庆霖刘超葛福蓉苑克俊李娟
Owner SHANDONG INST OF POMOLOGY
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