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Preparation method of miniature intelligent calcium alginate hydrogel end operator

A technology of end effector and calcium alginate, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, and medical devices, and can solve problems such as complex devices, difficult preparations, and non-degradability

Active Publication Date: 2019-12-10
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the existing drug carrier preparation technology has technical barriers such as complex devices, difficult preparation, and non-degradable

Method used

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  • Preparation method of miniature intelligent calcium alginate hydrogel end operator
  • Preparation method of miniature intelligent calcium alginate hydrogel end operator
  • Preparation method of miniature intelligent calcium alginate hydrogel end operator

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Embodiment Construction

[0022] The examples given below further illustrate the present invention, but the examples do not constitute any limitation to the present invention.

[0023] The invention provides a preparation method of a degradable self-rolling miniature intelligent calcium alginate hydrogel end effector, including electrodeposition, processing and picking.

[0024] Preferably, the electrodeposition further comprises:

[0025] In a preferred embodiment, the S11 further includes:

[0026] S1: Coat a photoresist with a thickness of about 10 μm on the FTO glass with a size of 50mm×50mm by a spin coating machine, and form a concave pattern of a specific shape on the FTO glass as an anode;

[0027] S2: Fill 2ml of deposition solution between two 3.5-4V electrodes, maintained by two insulating spacers with a height of 1mm;

[0028] S3: Apply DC voltage to the electrodes for 1-5 seconds;

[0029] S4: The anode was washed in HEPES buffer for 5 minutes until all hydrogel microstructures were det...

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Abstract

The invention provides a preparation method of a miniature intelligent calcium alginate hydrogel end operator based on different microelectrodes. The method comprises the steps of an electrodepositionstep: enabling a deposition solution to be deposited under the action of a non-uniform magnetic field to form an anode surface; a treatment step: transferring an obtained hydrogel microstructure to acalcium chloride solution, and enabling the hydrogel microstructure to realize sufficient self-winding; a collecting step: collecting a self-wound alginate single layer film microstructure in a culture dish, and performing placing in specific environment for preservation. A degradable and convenient micro-operator can be provided, and can be locally prepared into different function components.

Description

technical field [0001] The invention belongs to the technical field of drug microcarriers, and in particular relates to a preparation method of a miniature intelligent calcium alginate hydrogel end manipulator based on different microelectrodes. Background technique [0002] Drug delivery refers to the delivery of drugs to the lesion site in a specific way, so as to achieve the purpose of treating diseases. Common clinical drug delivery methods include enteral administration, parenteral administration, and topical administration. Oral administration and rectal administration are two types of enteral administration. The drug is absorbed by the gastrointestinal mucosa, liver or rectal mucosa, etc., enters the blood, and is transported to the whole body through blood circulation, so as to achieve the purpose of treating diseases. Intravenous, intramuscular, and subcutaneous injections are three common parenteral administration methods, which refer to the injection of drugs dir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61K47/36A61K9/06
CPCA61K9/06A61K47/36A61M31/00A61M2205/10A61M2205/3515A61M2207/00C08B37/0084C08L5/04C25D1/00C25D1/20A61M31/002A61M2205/02C09D5/44C25D1/08C25D5/34C25D5/007C25D5/605
Inventor 王化平石青郑志强刘仕杰谭嘉伟黄强福田敏男
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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