Glucose infusion solution composition
A technology of composition and glucose, which is applied in the direction of drug delivery, medical preparations of non-active ingredients, organic active ingredients, etc., can solve the problems of stability damage, water damage, etc., to improve stability, promote health, and strengthen the immune system Effect
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experiment Embodiment 1
[0027] Experimental Example 1. Preparation of Infusion Solution Containing Sugar and Stabilizer
[0028] A. Materials and equipment
[0029] Eight sugars purchased from Sigma-Aldrich (Saint Louis, MO, USA), namely, glucose, galactose, mannose, L-fucose, xylose, N-acetylglucosamine, N-acetylgalactose, were used Amines and N-acetylneuraminic acid.
[0030] To adjust the pH of the sample, 1N NaOH solution (Samchun Pure Chemical Co., Ltd.) was used.
[0031] As stabilizers, sodium bisulfite (Sigma-Aldrich) and EDTA-2Na dehydrate (disodium edetate dihydrate) with a purity exceeding 98% were used, Daejung Chemicals & metals Co., Ltd. ).
[0032] The amino acid used to replace the stabilizer of the present invention is a Sigma-Aldrich product with a purity of over 97%, and the stabilizing effect of the amino acid is compared with that of a sample treated directly with the stabilizer.
[0033] The above-mentioned components were used after being dissolved in water for injection (J...
experiment Embodiment 2
[0062] Experimental Example 2. Samples Containing Stabilizers
[0063] A. Add stabilizer
[0064] Among additives for injection, each of sodium bisulfite and EDTA-2Na dihydrate, which are often used as stabilizers, was added to the sample F6 prepared in Example 1-B, and the color of the sample was observed and measured , changes in pH and osmotic pressure.
[0065] First, 200 μL of sample F6 was added to 1800 μL of water for injection, and then stirred at room temperature, thereby preparing six samples each consisting of 2 mL of 10-fold diluted sugar solution (sample a, a-1, b, b-1, c and c-1).
[0066] Next, the pH of each of the six samples was measured and then adjusted with NaOH to approximate the in vivo plasma pH of 7.4.
[0067] A 0.1% sodium bisulfite solution was prepared by mixing 5 mg of sodium bisulfite as a stabilizer with 5 mL of water for injection, and a 0.2% EDTA-2Na dihydrate was prepared by mixing 10 mg of EDTA-2Na dihydrate with 5 mL of water for injecti...
Embodiment 3
[0086] Example 3. Preparation of Amino Acid-Containing Samples
[0087] A. Sample Preparation
[0088] The stabilizing effect of added amino acids was tested.
[0089] According to the dilution method of Example 1-(C), 2 mL of sugar solution was prepared by diluting the sample 10 times.
[0090] Next, each of the 17 amino acids was added to the sugar solution, and the time-dependent changes in color, pH and osmotic pressure of each solution were measured.
[0091] Of the 20 amino acids that make up proteins, cysteine and tryptophan were excluded because they showed too high an initial change in osmotic pressure when added in preliminary experiments, and tyrosine was excluded because of its excessive solubility. Low (0.45) it barely dissolves.
[0092] It can be seen that the addition of amino acids to the samples showed minimal changes in color, pH and osmolarity compared to the control containing a 10-fold diluted sugar solution without amino acids, which had the best st...
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