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Quick magnetic resonance imaging method for lung compliance quantitative assessment

A technology of magnetic resonance imaging and quantitative evaluation, which is applied in application, evaluation of respiratory organs, diagnostic recording/measurement, etc. It can solve problems such as long proton MRI sampling time, difficulty in distinguishing ventilation defect areas, and inability to accurately calculate lung volume. The effect of high speed, reduced inspection time, and short scanning time

Inactive Publication Date: 2019-12-31
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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AI Technical Summary

Problems solved by technology

Due to X-ray attenuation and lower proton spin density in the lung than in other tissues, the lung often appears as a dark hypointense area on CT and proton MRI, making it difficult to distinguish contributions to lung volume calculations on CT and proton MRI images Fewer regions of ventilatory deficits, which prevent accurate calculation of lung volumes
At the same time, the ionizing radiation of CT limits the promotion of repeated scanning technology in clinical practice, while the traditional clinical proton MRI has a long sampling time and cannot obtain lung gas signals

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  • Quick magnetic resonance imaging method for lung compliance quantitative assessment
  • Quick magnetic resonance imaging method for lung compliance quantitative assessment
  • Quick magnetic resonance imaging method for lung compliance quantitative assessment

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Embodiment Construction

[0024] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and understandable, the following in conjunction with the attached Figure 1~3 Taking the hyperpolarized inert gas fast magnetic resonance imaging of rats under a 7T magnetic resonance imager as an example, the specific embodiment of the present invention will be described in detail.

[0025] A fast magnetic resonance imaging method for quantitative evaluation of lung compliance, comprising the following steps:

[0026] Step 1. The subject inhales hyperpolarized inert gas and holds his breath. Measure the airway pressure during the subject's breath-hold. The subjects in this embodiment are rats, but may also be other animals or humans. Hyperpolarized noble gases including hyperpolarized 3 He, Hyperpolarized 83 Kr, Hyperpolarization 129 Xe, or hyperpolarized 131 Xe. The device for realizing the above-mentioned delivery of hyperpolarized inert gas, breath-ho...

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Abstract

The invention discloses a quick magnetic resonance imaging method for lung compliance quantitative assessment. The magnetic resonance imaging method comprises the steps of enabling an examinee to inhale hyperpolarization inert gas, enabling the examinee to hold breath, and obtaining airway pressure when the examinee holds the breath; performing calculation to obtain lung volumes according to hyperpolarization inert gas ventilation quick magnetic resonance images; obtaining n groups of ventilation quantities, airway pressures and lung volumes; obtaining a pressure-volume curve; and calculatingthe slope of a lung compliance fitting straight line. According to division of the lung regions, the compliance of different lung lobes of the lungs can be obtained, and the volumes of the lungs are accurately calculated. Ionization radiation and radioactivity do not exist, the scanning time is short, the sampling speed is high, and besides, the quick magnetic resonance imaging method is accurateand direct, so that the quick magnetic resonance imaging method is suitable for clinical promotion.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a fast magnetic resonance imaging method for quantitative evaluation of lung compliance. It is suitable for quantitative evaluation of lung compliance by means of hyperpolarized inert gas fast magnetic resonance. Background technique [0002] In recent decades, hyperpolarized inert gas fast MRI has been proven to be an effective technique for imaging lung cavities. Compared with other clinical imaging techniques, its extremely high sensitivity, rapid sampling and specificity make it an effective technique in the early stages of lung disease. It has unique advantages in detection. Rapid imaging of ventilation with inert gas is the most intuitive manifestation of pulmonary ventilation function. Inert gases often exhibit low or even unobservable signals in areas of deficient lung ventilation. These areas are usually due to narrowing of the small airways causing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B5/03A61B5/08
CPCA61B5/03A61B5/055A61B5/08
Inventor 周欣张鸣李海东李红闯娄昕孙献平叶朝辉
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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