Unlock instant, AI-driven research and patent intelligence for your innovation.

Magnetic particle luminescence double-layer micro-fluidic chip and detection system

A technology of microfluidic chips and magnetic particles, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as the inability to define the flow path of samples

Pending Publication Date: 2020-01-03
SHENZHEN HUAMAIXINGWEI MEDICAL TECH CO LTD
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The embodiment of the present invention provides a magnetic particle light-emitting double-layer microfluidic chip and a detection system, aiming to solve the problem that in the existing microfluidic chip, after the sample flows from the top plate to the bottom plate, it directly flows in the bottom plate, and the flow of the sample cannot be limited. problem with path

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Magnetic particle luminescence double-layer micro-fluidic chip and detection system
  • Magnetic particle luminescence double-layer micro-fluidic chip and detection system
  • Magnetic particle luminescence double-layer micro-fluidic chip and detection system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] refer to figure 1 and figure 2 , the first embodiment provides a magnetic particle light-emitting double-layer microfluidic chip. The magnetic particle light-emitting double-layer microfluidic chip includes a top plate 1 and a bottom plate 2 arranged on the top plate 1 .

[0028] The top plate 1 includes a sample loading section 11, a labeled ligand storage section 12, and a sample mixing area 13. The labeled ligand storage section 12 is provided with a labeled ligand, and the sample mixing section 13 is connected to the sample loading section 11 and the labeled ligand storage section 12 respectively. interconnected.

[0029] The base plate 2 includes a diversion area 21 communicating with the sample mixing area 13, a magnetic particle coating part 22 communicating with the diversion area 21, a cleaning area 23 communicating with the magnetic particle coating part 22, and a cleaning area 23 communicating with the cleaning area 23. The connected detection area 24 and ...

Embodiment 2

[0036] refer to figure 1 On the basis of the first embodiment, the top plate 1 of the fourth embodiment is also provided with an air pump 14 communicating with the sample loading unit 11. The air pump 14 is an air bag built into the top plate 1. By repeatedly squeezing or releasing the air bag, The air in the airbag repeatedly enters and exits the sample adding part 11 and the sample mixing area 13 , thereby driving the liquid in the top plate 1 to flow.

[0037] The air pump 14 is used to absorb or extrude the air in the sample mixing area 13, so that the sample and the labeled ligand flow to the sample mixing area 13, and by repeatedly absorbing or extruding the air in the top plate 1, the sample and the labeled ligand are mixed in the sample. The mixing zone 13 is thoroughly mixed, and after mixing, the sample is driven from the sample mixing zone 13 into the diversion zone 21 .

[0038] It should be noted that since the air pump 14 needs to work in a sealed environment, i...

Embodiment 3

[0040] refer to figure 1 , on the basis of the second embodiment, the top plate 1 of the third embodiment is provided with elastic members in the air pump 14 and the sample mixing area 13 . The elastic member can optionally be glued to one side of the top board 1 , and one side of the top board 1 is adjacent to the bottom board 2 . The elastic member can provide elastic effect for the air pump 14 and the sample mixing area 13 .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of micro-fluidic chip luminescence immunoassay, and particularly relates to a magnetic particle luminescence double-layer micro-fluidic chip and a magneticparticle luminescence double-layer micro-fluidic detection system. The magnetic particle luminescence double-layer micro-fluidic chip comprises a top plate and a bottom plate, wherein the top plate comprises a sample adding part, a labeled ligand storage part and a sample mixing region, and the sample mixing region is communicated with the sample adding part and the labeled ligand storage part respectively; and the bottom plate comprises a flow guide region, a magnetic particle coating part, a cleaning region, a detection region and a cleaning liquid storage part, a groove lower than the bottom wall of the magnetic particle coating part is formed in the flow guide region, and a flow guide part arranged on the groove and connected with the magnetic particle coating part is arranged in theflow guide region. A sample enters from the sample adding part, is mixed with a labeled ligand in the sample mixing region and then enters the groove in the flow guide region, the sample in the groovecan be sucked away through capillary action, and the sample can only enter the magnetic particle coating part from the flow guide part and react with magnetic particle ligands in a mixed mode due tothe action of a cut-off groove and a blocking part, and luminescence detection is achieved in the detection region after the product is cleaned in the cleaning region.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chip luminescent immunodetection, and in particular relates to a magnetic particle luminescent double-layer microfluidic chip and a detection system. Background technique [0002] At present, there are two main development trends for in vitro diagnostics (IVD): one is automation and integration, that is, the use of fully automated and highly sensitive large-scale instruments and equipment in the central laboratory of a large hospital to achieve high-precision disease analysis and diagnosis ; Another kind of miniaturization and bedside, that is, to realize rapid analysis and diagnosis on the spot through small and simple handheld devices. However, small hospitals with insufficient funds and small sample sizes are not suitable for purchasing large and expensive equipment. Therefore, the rapid detection equipment used by most hospitals at this stage is mainly test strips and their supporting eq...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N33/533G01N33/543
CPCG01N33/533G01N33/54326G01N33/54386
Inventor 王东范玉霞李泉
Owner SHENZHEN HUAMAIXINGWEI MEDICAL TECH CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com