Graphene oxide fiber bragg grating-based gold nanoshell LSPR photopole biosensor

Abstract

The invention relates to a photopole biomolecular sensor, in particular to a graphene oxide fiber bragg grating-based gold nanoshell LSPR photopole biosensor. The graphene oxide fiber bragg grating-based gold nanoshell LSPR photopole biosensor comprises a fiber core, a fiber cladding and a fiber coating layer, wherein a large-angle tilting fiber bragg grating is arranged at the tail end of the fiber core; a coating layer on the surface of the cladding of the large-angle tilting fiber bragg grating is completely removed; the end surface of the tail end of the large-angle tilting fiber bragg grating is coated with a silver reflective film; a silane layer is arranged on the surface of the cladding of the large-angle tilting fiber bragg grating; a gold nanoshell particle layer is fixed on thesurface of the silane layer; a graphene oxide layer is adsorbed to the surface on which the gold nanoshell particle layer is fixed; and a biomolecular sensitive layer is fixed on the surface of the graphene oxide layer. By adopting the photopole biosensor structure provided by the invention, the operating distances of LSPR excited by a light wave evanescent field and biomolecules can be increased,and the photopole biosensor structure is convenient to integrate and use, has very high robustness and can be applied to the field of biology, medicine, environment monitoring, food safety, life science and the like.

Description

technical field [0001] The invention relates to an optode biomolecular sensor, in particular to a nano-gold shell LSPR optode biosensor of graphene oxide optical fiber grating. Background technique [0002] Graphene has excellent characteristics such as large specific surface area, high electron mobility, high conductivity, and biomolecular affinity. Its oxide, graphene oxide, also contains abundant oxygen-containing functional groups such as carboxyl and hydroxyl groups. It is beneficial for covalent or non-covalent linking with biomolecules, etc. Therefore, the biochemical sensing technology that combines two-dimensional materials such as graphene and graphene oxide with traditional electrochemical, piezoelectric, and optical (such as: surface plasmon resonance sensors, various types of optical fiber sensors) sensors has been obtained. Extensive research. [0003] In the field of biochemical detection, the Surface Plasmon Resonance (SPR) sensor is an optical sensor that ...

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Problems solved by technology

[0007] In order to solve the problem that the quality factor of the pure optical fiber LSPR sensor is very low, the present invention provides a nano-gold shell LSPR photoelectrode biosensor of graphene oxide fiber grating

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