Gallium-containing polycaprolactone/bioglass porous bone repair 3D printed scaffold and its application in the repair of infected bone defects

Abstract

The invention discloses a gallium-containing polycaprolactone / bioglass porous bone repair 3D printing scaffold and its application in the repair of infectious bone defects. Gallium has good antibacterial properties, and can also inhibit osteoclast differentiation, effectively inhibiting possible osteolysis in bone infection. Bioglass has the ability to promote osteogenic differentiation, and mesoporous bioglass particles have a pore structure that can load components and release them slowly. The invention combines the antibacterial and osteocracking effects of gallium and the osteogenic differentiation promoting effect of bioglass, directly removes local infection foci and further regulates the balance of osteogenesis and osteoclastion in the process of bone repair. The invention applies 3D printing technology and utilizes the good biocompatibility and mechanical support of polycaprolactone to construct a functional bone repair scaffold whose structure can be flexibly designed according to the characteristics of the defect site and whose size is controllable. has important application prospects.

Description

Gallium-containing polycaprolactone / bioglass porous bone repair 3D printed scaffold and its application in infection Application in repair of bone defect technical field The present invention relates to the field of biomedical materials, in particular to gallium-containing polycaprolactone / bioglass porous bone repair 3D Printed scaffolds and their application in the repair of infected bone defects. Background technique [0002] After severe trauma and bone tumor resection, large bone defects can be caused, and bone filling materials are often required for treatment. and The local defect, especially in the presence of exogenous bone filling materials, has a high risk of bacterial exposure and is easy to adhere. and due to trauma The local soft tissue is severely damaged, and the ability of the local autoimmune system to clear bacteria is reduced, which further increases the infectious bone defect. Difficulty of treatment. When severe infection exists, a second oper...

AI Technical Summary

Problems solved by technology

In the defect area, especially in the presence of exogenous bone filling materials, there is a high risk of bacterial exposure and easy adhesion

In addition, due to the serious damage to the local soft tissue of the trauma, the ability of the local autoimmune system to eliminate bacteria is reduced, which further increases the difficulty of the treatment of infectious bone defects.

When severe infection exists, a second operation is often required to remove the infected bone filling material, thoroughly debride the wound and eliminate the infection focus, and then long-term high-dose antibiotic treatment will bring serious pain and economic burden to the patient

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