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Composition comprising mannose oligosaccharide and process for making same and use thereof

A technology of mannan oligosaccharide and composition, applied in the field of animal feed, can solve the problems of limitation, impractical application, no consistent composition and the like

Pending Publication Date: 2020-02-04
CARGILL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They all present the disadvantages of not being a highly pure composition and not having a consistent composition, especially for yeast cell wall extracts, so their effects in animals are less predictable and their effects are very variable
As a result, their use in liquid feed and drinking water is impractical and thus limited
Furthermore, the production process of this mannose oligosaccharide composition has a non-negligible impact on the environment due to the generation of many waste streams

Method used

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  • Composition comprising mannose oligosaccharide and process for making same and use thereof
  • Composition comprising mannose oligosaccharide and process for making same and use thereof
  • Composition comprising mannose oligosaccharide and process for making same and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Example 1: Production of MOS composition

[0098] With a weight ratio of 100:3 on a dry basis, a mannose solution (C*TruSweet 016Ko from Cargill) containing 90 wt% + / - 2% mannose on a dry basis was blended with solid citric acid. The resulting solution was evaporated via a thin film evaporator to a dry matter of 85% + / - 1%. The solution was then heated to 165°C by pumping through a micro heat exchanger (Kreuzxtrom-reaktormodul 1694-X-19.0, KIT, IMVT) at a constant flow rate of 15 kg / hr, with a total residence time shorter than 2 seconds. The material was then pumped through a second micro heat exchanger (Kreuzxtrom-reaktormodul 2155-A-4.0, KIT, IWVT) for 11 seconds at a temperature of 195°C, where the main polycondensation reaction occurred.

[0099] The obtained polycondensation product (mannose oligosaccharide composition) was diluted with alkaline water to obtain a solution with a solid content of 50% by weight and a pH of 5+ / -0.2. The solution was then cooled to 50°C....

Embodiment 2

[0100] Example 2: Production of MOS composition

[0101] With a weight ratio of 100:3 on a dry basis, a mannose solution (C*TruSweet 016Ko from Cargill) containing 90 wt% + / - 2% mannose on a dry basis was blended with solid citric acid. The resulting solution was evaporated via a thin film evaporator to a dry matter of 85% + / - 1%. The solution was then heated to 170°C by pumping through a micro heat exchanger (Kreuzxtrom-reaktormodul 1694-X-19.0, KIT, IMVT) at a constant flow rate of 15 kg / hr, with a total residence time shorter than 2 seconds. The material was then pumped through a second micro heat exchanger (Kreuzxtrom-reaktormodul 2155-A-4.0, KIT, IWVT) for 11 seconds at a temperature of 200°C, where the main polycondensation reaction occurred.

[0102] The obtained polycondensation product (mannose oligosaccharide composition) was diluted with alkaline water to obtain a solution with a solid content of 50% by weight and a pH of 5+ / -0.2. The solution was then cooled to 50°C....

Embodiment 3

[0103] Example 3: Comparative example

[0104] The MOS according to the present invention (composition A and composition B prepared according to Examples 1 and 2, respectively) were compared with commercially available yeast-derived MOS compositions (samples C to I).

[0105] The solubility was determined according to Test A as described above.

[0106] The results show that the solubility of all commercial yeast-derived samples is lower than 4wt%, which is much lower than the solubility of the product of the present invention.

[0107] Table 1. Sugar profile and solubility of mannooligosaccharide (MOS) samples determined by HPLC.

[0108]

[0109] Stability to acid and feed enzymes

[0110] Commercially available MOS samples extracted from yeast And according to reality

[0111] The sample of the MOS composition according to the present invention prepared in Example 1 is under conditions of stimulating gastric acid (pH 2 for the first 30 minutes and then pH 7) at 41° C. (the internal ...

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Abstract

The present invention relates to a composition comprising mannose oligosaccharide and a process for making such. The present invention further relates to a composition comprising mannose oligosaccharide for use in the treatment of a human or animal.

Description

[0001] Cross references to related applications [0002] This application claims the rights of European Patent Application No. 17175981.4 filed on June 14, 2017, which is incorporated herein by reference in its entirety. [0003] Invention field [0004] The present invention relates to a composition containing mannose oligosaccharides and a method for preparing the composition. The invention further relates to an animal feed comprising the composition of the invention. The invention further relates to a composition according to the invention for the treatment of humans or animals, in particular for promoting the growth of humans and animals and / or feed utilization and / or reducing bacterial infections. [0005] Background of the invention [0006] There is currently a need for nutritional supplements to improve the overall health of people, farm animals, farmed fish, and pets, especially intestinal health. [0007] With the increase of the world's population, the demand for animal prote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A23K10/00
CPCA61K31/702A23K10/00A23K20/163A23K50/75A23K50/30A23K50/60A61P31/04Y02A50/30A61K8/60A61Q1/00A61Q19/00A23L33/125A23L33/40A23V2002/00A61K2800/10A61Q11/00
Inventor 布鲁诺·弗雷德里克·斯坦格尔克里斯托夫·弗朗兹·库斯特尔斯
Owner CARGILL INC