Singlet oxygen scavenger

A technology of singlet oxygen and scavenger, applied in the direction of antitoxin, preparations for skin care, cosmetics, etc., can solve the problem of unpredictable effect, etc., and achieve the effect of inhibiting reaction and high scavenging ability

Active Publication Date: 2020-02-07
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, active oxygen species have inherent characteristics depending on their type as described above. For example, it is impossible to predict whether a radical-based active oxygen scavenger such as Patent Document 3 functions as a singlet oxygen scavenger.

Method used

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  • Singlet oxygen scavenger

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0048] The singlet oxygen scavenging ability of the singlet oxygen scavenger of the present invention was evaluated by measuring the singlet oxygen quenching rate constant kQ by the following method.

[0049]

[0050] (1) Detector

[0051] Near-infrared photomultiplier tube module, Hamamatsu Photonics Co., Ltd.

[0052] Type: H10330A-45, wavelength range: 950~1400nm

[0053] (2) Optical splitter

[0054] Small beam splitter, Shimadzu Corporation

[0055] Type: SPG-120IR, wavelength range: 700~2500nm

[0056] (3) Light source

[0057] Nd: YAG laser, Continuum (Continuum, USA)

[0058] Type: Surelite I, Wavelength Range: 1064, 532, 355, 266nm

[0059] (4) Data processing

[0060] Digital oscilloscope, Tektronix (Tektronix Corporation, USA)

[0061] Type: TDS 3012C, Frequency Band: 100MHz

[0062]

[0063] (sample preparation)

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PUM

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Abstract

The object of the invention is to provide a singlet oxygen scavenger having high singlet oxygen scavenging ability. This singlet oxygen scavenger contains, as active ingredients, benzyl diethylaminohydroxybenzoylbenzoate, 1-(4-methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione, a terephthalyliden-3,3'-dicamphor-10,10'-disulfonic acid salt, 2-ethylhexyl 4-methoxycinnamate or 2-ethylhexyl 2-cyano-3,3-diphenylacrylate or 2-phenylbenzimidazole-5-sulfonic acid, tris(2-ethylhexyl) 4,4',4''-[(1,3,5-triazin-2,4,6-triyl)tris(imino)]trisbenzoate, octyl salicylate or 3,3,5-trimethylcyclohexyl salicylate or 2-hydroxy-4-methoxy-5-(sodiooxysulfonyl)benzophenone, drometrizole trisiloxane, and 2-hydroxy-4-methoxybenzophenone or 4-methylbenzylidene camphor.

Description

technical field [0001] The present invention relates to singlet oxygen scavengers. Background technique [0002] Humans live using oxygen, but it is known that a part of oxygen becomes active oxygen, and the active oxygen causes various diseases and aging. Active oxygen species generated by ultraviolet rays are also recognized as substances that cause skin damage and early aging. In addition, substances having a scavenging effect on active oxygen species are also known. For example, as substances having radical scavenging activity, there are benzophenone derivatives derived from Hypericum plants (Patent Document 1), source Flavonoids in plant extracts, tannins (Patent Document 2), various plant extract groups, 2-hydroxy-4-methylbenzophenone-5-sulfate (Patent Document 3), and the like. [0003] However, active oxygen species are broadly classified into radical active oxygen species and non-radical active oxygen species. As the active oxygen species of free radicals, starti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/368A61K8/39A61K8/58A61K31/12A61K31/125A61K31/185A61K31/216A61K31/24A61K31/277A61K31/4184A61K31/53A61K31/618A61K31/695A61K31/80A61P39/06A61Q17/04
CPCA61K31/125A61K31/185A61K31/216A61K31/24A61K31/277A61K31/4184A61K31/53A61K31/618A61K31/695A61K31/80A61P39/06A61Q17/04A61K2800/522A61Q19/08A61K8/4946A61K8/445A61K8/35A61K8/466A61K8/37A61K8/40A61K8/4966A61K8/585C09K15/06C09K15/12C09K15/20C09K15/30A61K8/39A61K8/49A61K8/58A61K8/368
Inventor 宫泽和之藤山希菊地梓八木干雄
Owner SHISEIDO CO LTD
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