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Application of tetracera asiatica and extract thereof to preparation of medicine for treating and/or preventing alcoholic liver injury

A technology of sycamore and its extract, which is applied in the field of pharmaceutical application, can solve the problems that there is no sycamore and its extract, so as to restore the protein synthesis function, reduce the degree of acute liver injury, and increase the albumin content Effect

Active Publication Date: 2020-02-14
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the application of safflower and its extracts in the preparation of drugs for the treatment and / or prevention of alcoholic liver injury

Method used

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  • Application of tetracera asiatica and extract thereof to preparation of medicine for treating and/or preventing alcoholic liver injury
  • Application of tetracera asiatica and extract thereof to preparation of medicine for treating and/or preventing alcoholic liver injury
  • Application of tetracera asiatica and extract thereof to preparation of medicine for treating and/or preventing alcoholic liver injury

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The preparation of embodiment 1 sycamore water extract

[0040] Tinleaf vine was collected in Wumingfengfeng Forest Farm, Guangxi, and was identified as the stem of Tetracera asiatica (Lour.) Hoogland by Associate Professor Teng Jianbei of Guangxi University of Traditional Chinese Medicine. Take 200g of pulverized vine powder, add 5000mL of pure water each time, decoct at 100°C for 1 hour, repeat 3 times, combine the extracts obtained 3 times, concentrate into water extract extract, make each 1g of water extract The crude drug content in the ointment is 7.0771g.

Embodiment 2

[0041] The preparation of embodiment 2 tin yetogen alcohol extract

[0042] Tinleaf vine was collected in Wumingfengfeng Forest Farm, Guangxi, and was identified as the stem of Tetracera asiatica (Lour.) Hoogland by Associate Professor Teng Jianbei of Guangxi University of Traditional Chinese Medicine. Get 100 g of the pulverized vine medicinal powder, add 2500 mL each time, 50% ethanol, reflux extraction in a water bath at 80° C. for 1 h, repeat 3 times, combine the obtained extracts for 3 times, concentrate to obtain the ethanol extract of vine vine, and make 1g of alcohol extract contains 6.9638g of crude drug.

Embodiment 3

[0043] The preparation of embodiment 3 vine ethyl acetate extract, n-butanol extract

[0044] Get the alcohol extract extract obtained in Example 2, disperse it in 50% ethanol, and use ethyl acetate to continuously extract 15 times, each 50mL, and the extracts are combined to obtain the extract of the vine ethyl acetate extract; Continuously extract 15 times with n-butanol, 50 mL each time, and combine the extracts to obtain the extract of n-butanol extract of Tinja chinensis. Then concentrated at 80° C., so that 1 g of ethyl acetate extract contains 52.0833 g of crude drug, and 1 g of n-butanol extract contains 41.6667 g of crude drug.

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Abstract

The invention relates to the field of medicine application, in particular to application of tetracera asiatica and an extract thereof to preparation of a medicine for treating and / or preventing alcoholic liver injury. The tetracera asiatica extract is selected from any one of a mixture of more than one of the following components: a tetracera asiatica water extract, a tetracera asiatica alcohol extract, a tetracera asiatica ethyl acetate extract and a tetracera asiatica normal butanol extract. The tetracera asiatica extract provided by the invention can obviously increase the albumin content of serum of mice suffering from alcoholic liver injury and can improve the albumin synthesis ability of the liver by repairing endoplasmic reticulum, golgiosome, ribosome and the like of injured cellsso as to provide protection for the liver.

Description

technical field [0001] The invention relates to the field of medicine application, in particular to the application of sycamore and its extract in the preparation of medicines for treating and / or preventing alcoholic liver injury. Background technique [0002] Tin leaf vine is the root of Tetracera asiatica (Lour.) Hoogland. It is cool in nature, bitter in the mouth, and has the functions of restraining diarrhea, reducing swelling and relieving pain. Commonly used in the treatment of diarrhea, dysentery, proctoptosis and other diseases. Its medicinal materials are rich in tannins, flavonoids, terpenoids and other biologically active ingredients, which have obvious antibacterial, anti-inflammatory, anti-tumor activities [State Administration of Traditional Chinese Medicine Chinese Materia Medica Editorial Committee. Zhonghua Materia Medica [M ]. Volume 3. Shanghai: Shanghai Science and Technology Press, 1999: 510-511.]. Tin leaf vine is rich in medicinal resources, and is ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16
CPCA61K36/185A61P1/16
Inventor 笪舫芳
Owner GUANGXI UNIV OF CHINESE MEDICINE
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