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Blocking agent for preventing cavity and mucosal infection and preparation method of blocking agent

A technology of blocking agent and cavity, applied in the field of medical devices, can solve the problem of unclear antiviral mechanism, and achieve the effects of superior film-forming performance, simple process, and reduced incidence of disease.

Inactive Publication Date: 2020-02-21
南京东万先卓生物科技研发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its antiviral mechanism is still unclear

Method used

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  • Blocking agent for preventing cavity and mucosal infection and preparation method of blocking agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: preparation process

[0024] (1) Ultrafine grinding of raw materials: Ultrafine grinding of HPMC and signal agent; dynamic monitoring during the grinding process, 90% of the particle size distribution is 10-500 μm, and the minimum particle size shall not be less than 10 μm.

[0025] (2) Premixing: Accurately weigh an equal amount of HPMC and lavender powder, mix them uniformly and pass through a 200-mesh sieve; accurately weigh an equal amount of HPMC and the mixture in the previous step, mix them uniformly and pass through a 200-mesh sieve.

[0026] (3) Total mixing: Repeat the premixing process of step (2). After the premixing is completed, put the materials into the mixer and mix for one hour.

[0027] (4) Encapsulation: 500mg / bottle, 1000mg / bottle.

Embodiment 2

[0028] Example 2: Investigation of the film-forming performance of spraying different times of barrier powder

[0029] The barrier agent prepared in Example 1 was placed in an environment of 37° C. and 95% humidity, and the film-forming time of powders of different components was observed.

[0030]

Embodiment 3

[0031] Embodiment 3: Nasal irritation test

[0032] The barrier agent prepared in Example 1 was administered through the nasal cavity of rabbits for seven consecutive days; single administration and multiple administrations alternated during the experiment. It is observed that the nose of the rabbit has no symptoms such as edema, and the times of scratching the nose and sneezing are normal; the results show that the present invention has no obvious stimulation to the nose of the rabbit.

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Abstract

The invention relates to a blocking agent for preventing cavity and mucosal infection and a preparation method of the blocking agent. The method relates to the field of medical devices. The method comprises the following steps: mixing natural inert cellulose with a certain particle size range and a signal agent, and performing subpackage and sealing. The blocking agent for preventing the cavity and mucosal infection prepared by the method has good biocompatibility, can prevent various dust particles from harming human bodies and prevent various pathogenic microorganisms from entering the bodies to cause diseases, is in line with green processing process requirements, and has a simple process, low production costs and broad application prospects.

Description

technical field [0001] A blocking agent for preventing cavities and mucous membrane infection and a preparation method thereof, the method relates to the field of medical devices. Background technique [0002] At present, the infection of cavity and mucosa is becoming more and more serious, and various diseases caused by infection of cavity and mucosa are gradually affecting people's normal life. [0003] Cavities and mucous membranes play a very important protective role in the normal physiological activities of humans. The following will take the respiratory tract as an example to illustrate. Secretion and cilia are distributed on the inner surface of the entire respiratory tract, which can warm, moisten and purify the inhaled air, and have a protective effect on respiratory organs and the human body. The respiratory mucosa is attached to a layer of columnar ciliated epithelial cells, which has a mechanical barrier effect; the respiratory mucosal epithelial goblet cells a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/10A61K47/38A61K47/46A61P31/04A61P31/12
CPCA61K9/0043A61K47/10A61K47/38A61K47/46A61P31/04A61P31/12
Inventor 尹鸿萍乐龙张健
Owner 南京东万先卓生物科技研发有限公司