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Application of 1,8-dihydroxy-3-methylanthraquinone in preparing medicine for treating acute lung injury

A technology of acute lung injury and chrysophanol, applied in the field of medicine, can solve problems such as no reports of acute lung injury, and achieve the effect of reducing pulmonary capillary permeability and reducing pulmonary edema

Inactive Publication Date: 2020-02-21
XUZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the pharmacological research of this kind of compound on acute lung injury.

Method used

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  • Application of 1,8-dihydroxy-3-methylanthraquinone in preparing medicine for treating acute lung injury
  • Application of 1,8-dihydroxy-3-methylanthraquinone in preparing medicine for treating acute lung injury
  • Application of 1,8-dihydroxy-3-methylanthraquinone in preparing medicine for treating acute lung injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Chrysophanol inhibits inflammation in ALI mice

[0025] 1. Experimental animals

[0026] C57BL / 6 healthy male mice, weighing 18-22g, SPF level, provided by the Animal Experimental Center of the School of Life Sciences, Nanjing University, the experimental animal production license number: SCXK (xiang) 2019-0004.

[0027] 2. Main reagents

[0028] Chrysophanol, lipopolysaccharide: purchased from Sigma-Aldrich (St. Louis, MI);

[0029] MPO detection kit: purchased from Nanjing Jiancheng Institute of Biological Engineering;

[0030] ELISA detection kit for TNF-α and IL-1β: Biolegend (San Diego, CA)

[0031] NF-κB, NLRP3 antibody: Cell Signaling Technology Inc. (Beverly, MA)

[0032] 3. Data processing

[0033] Using SPSS18.0 analysis and statistics software, the experimental data is expressed as mean±SD (Mean±SD). Statistical analysis adopts one-way analysis of variance (One Way ANOVA), the Dunnet t test is used to compare multiple experimental groups with a control group, an...

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Abstract

The invention discloses an application of 1,8-dihydroxy-3-methylanthraquinone in preparing a medicine for treating acute lung injury. The 1,8-dihydroxy-3-methylanthraquinone provided by the inventionshows a good therapeutic effect on a lipopolysaccharide-induced acute lung injury mouse model and can effectively regulate NF-kappa B and NLRP3 signaling pathways, experiments confirm the 1,8-dihydroxy-3-methylanthraquinone has a significant anti-inflammatory effect on the acute lung injury and can effectively promote the lung injury repair in the middle and late stages of the acute lung injury, so that the 1,8-dihydroxy-3-methylanthraquinone can be used for preparing the medicine for treating the acute lung injury. A novel approach is provided for the treatment of the acute lung injury.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to the application of chrysophanol, in particular to the application of chrysophanol in the preparation of a medicine for treating acute lung injury. Background technique [0002] Acute lung injury (ALI) is a serious respiratory disease with rapid onset and a high mortality rate of over 40%, which is a serious threat to human health. A variety of factors can cause acute lung injury, such as bacterial infection, trauma, shock, acute pancreatitis, sepsis, aspiration, etc. The pathogenesis of acute lung injury is not yet clear. It is currently believed to be caused by the following two reasons: 1. Direct damage to lung cells caused by pathogenic factors, such as lung infection, lung contusion, drowning, and inhalation of toxic substances; 2. , The indirect result of acute systemic inflammation caused by various reasons, such as sepsis, acute pancreatitis, severe injury other than lungs, sho...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P11/00
CPCA61K31/122A61P11/00
Inventor 李荣鹏蒋杰邦谭时锐布会敏董国凯蒋继宏
Owner XUZHOU NORMAL UNIVERSITY
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